2LS7 | pdb_00002ls7

High Definition Solution Structure of PED/PEA-15 Death Effector Domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DEATH effector domain, DED	8089625	4001934	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DEATH domain	8089626	3000069	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DED	e2ls7A1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: DED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01335	Death effector domain (DED)	Death effector domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Astrocytic phosphoprotein PEA-15	protein binding binding kinase binding protein kinase C binding enzyme binding protein kinase binding	cellular response to stimulus positive regulation of cell communication extrinsic apoptotic signaling pathway via death domain receptors regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus cellular response to stimulus positive regulation of cell communication extrinsic apoptotic signaling pathway via death domain receptors regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of programmed cell death cell surface receptor signaling pathway regulation of apoptotic process biological regulation positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of cell communication cellular process apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling regulation of localization hexose transmembrane transport D-glucose import transport negative regulation of biological process carbohydrate transport negative regulation of transport negative regulation of transmembrane transport localization negative regulation of D-glucose import negative regulation of cellular process regulation of D-glucose import regulation of transport negative regulation of D-glucose transmembrane transport establishment of localization transmembrane transport regulation of transmembrane transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport negative regulation of signaling negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of signal transduction negative regulation of apoptotic process intracellular signal transduction intracellular signaling cassette MAPK cascade	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol intracellular organelle protein-containing complex cytoskeleton organelle membraneless organelle microtubule associated complex intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle nucleus cellular anatomical structure intracellular anatomical structure cytoplasm cytosol intracellular organelle protein-containing complex cytoskeleton organelle membraneless organelle microtubule associated complex intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR029546	Astrocytic phosphoprotein PEA-15, death effector domain	Domain
A	IPR001875	Death effector domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.