2KSN | pdb_00002ksn

Solution Structure of the N-terminal Domain of DC-UbP/UBTD2

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	UBTD2 N-terminal domain-like	8045620	4004570	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	UBTD2 N-terminal domain-like	8091077	3002484	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UBD	e2ksnA1	A: a+b two layers	X: N-terminal domain of DC-UbP (From Topology)	H: N-terminal domain of DC-UbP (From Topology)	T: N-terminal domain of DC-UbP	F: UBD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.225.20	Mainly Alpha	Up-down Bundle	Bacteriocin As-48	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16455	Ubiquitin-binding domain (UBD)	Ubiquitin-binding domain	This ubiquitin-binding domain is found in ubiquitin domain-containing proteins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ubiquitin domain-containing protein 2	-	-	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038169	DC-UbP/UBTD2, N-terminal domain superfamily	Homologous Superfamily
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR000626	Ubiquitin-like domain	Domain
A	IPR039869	Ubiquitin domain-containing protein 1/2	Family
A	IPR032752	DC-UbP/UBTD2, N-terminal domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8WUN7	atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma hepatocellular carcinoma malignant pancreatic neoplasm osteosarcoma tuberculosis breast cancer gastric cancer juvenile dermatomyositis medulloblastoma primitive neuroectodermal tumor Duchenne muscular dystrophy gastric carcinoma large cell medulloblastoma oligodendroglioma atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma hepatocellular carcinoma malignant pancreatic neoplasm osteosarcoma tuberculosis breast cancer gastric cancer juvenile dermatomyositis medulloblastoma primitive neuroectodermal tumor Duchenne muscular dystrophy gastric carcinoma large cell medulloblastoma oligodendroglioma subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.