Annotations: 2HI9

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Serpins	8070185	3001563	SCOP2B (2022-06-29)
A	SCOP2 Family	Serpins	8070184	4002658	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Serpins	8070185	3001563	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Serpins	8070185	3001563	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Serpin	e2hi9C1	A: a+b complex topology	X: Serpins (From Topology)	H: Serpins (From Topology)	T: Serpins	F: Serpin	ECOD (1.6)
A	Serpin	e2hi9A1	A: a+b complex topology	X: Serpins (From Topology)	H: Serpins (From Topology)	T: Serpins	F: Serpin	ECOD (1.6)
B	Serpin	e2hi9B1	A: a+b complex topology	X: Serpins (From Topology)	H: Serpins (From Topology)	T: Serpins	F: Serpin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.30.497.10	Alpha Beta	2-Layer Sandwich	Antithrombin	Chain I, domain 2	CATH (4.3.0)
C	2.30.39.10	Mainly Beta	Roll	Alpha-1-antitrypsin	domain 1	CATH (4.3.0)
A	3.30.497.10	Alpha Beta	2-Layer Sandwich	Antithrombin	Chain I, domain 2	CATH (4.3.0)
A	2.30.39.10	Mainly Beta	Roll	Alpha-1-antitrypsin	domain 1	CATH (4.3.0)
B	3.30.497.10	Alpha Beta	2-Layer Sandwich	Antithrombin	Chain I, domain 2	CATH (4.3.0)
B	2.30.39.10	Mainly Beta	Roll	Alpha-1-antitrypsin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00079	Serpin (serine protease inhibitor) (Serpin)	Serpin (serine protease inhibitor)	Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Plasma serine protease inhibitor	protein binding binding enzyme binding protease binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity acrosin binding protein binding binding enzyme binding protease binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity acrosin binding cation binding ion binding phosphatidylcholine binding phospholipid binding lipid binding quaternary ammonium group binding small molecule binding glycosaminoglycan binding carbohydrate derivative binding retinoic acid binding organic acid binding isoprenoid binding retinoid binding anion binding carboxylic acid binding monocarboxylic acid binding heparin binding sulfur compound binding	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation localization transport macromolecule localization lipid localization lipid transport establishment of localization developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation localization transport macromolecule localization lipid localization lipid transport establishment of localization membrane organization membrane fusion plasma membrane fusion fertilization cellular process involved in reproduction in multicellular organism cellular component organization fusion of sperm to egg plasma membrane involved in single fertilization plasma membrane organization cellular process cellular component organization or biogenesis endomembrane system organization single fertilization negative regulation of hydrolase activity negative regulation of proteolysis regulation of cellular process regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of primary metabolic process negative regulation of peptidase activity regulation of proteolysis proteolysis negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation negative regulation of molecular function regulation of peptidase activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function regulation of hydrolase activity metabolic process macromolecule metabolic process regulation of metabolic process	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex serine protease inhibitor complex protease inhibitor complex peptidase inhibitor complex protein C inhibitor-coagulation factor V complex protein C inhibitor-coagulation factor XI complex protein C inhibitor-PLAU complex cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex serine protease inhibitor complex protease inhibitor complex peptidase inhibitor complex protein C inhibitor-coagulation factor V complex protein C inhibitor-coagulation factor XI complex protein C inhibitor-PLAU complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein C inhibitor-coagulation factor Xa complex protein C inhibitor-TMPRSS11E complex protein C inhibitor-PLAT complex intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle secretory granule secretory vesicle cytoplasm platelet alpha granule protein C inhibitor-plasma kallikrein complex protein C inhibitor-thrombin complex platelet dense tubular network acrosomal vesicle acrosomal membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane secretory granule membrane protein C inhibitor-TMPRSS7 complex protein C inhibitor-KLK3 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR023795	Serpin, conserved site	Conserved Site
A, B, C	IPR000215	Serpin family	Family
A, B, C	IPR036186	Serpin superfamily	Homologous Superfamily
A, B, C	IPR023796	Serpin domain	Domain
A, B, C	IPR042178	Serpin superfamily, domain 1	Homologous Superfamily
A, B, C	IPR042185	Serpin superfamily, domain 2	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: P05154	amphetamine abuse cholestasis atopic eczema cutaneous lupus erythematosus pancreatic intraductal papillary-mucinous carcinoma psoriasis Amphetamine Addiction breast fibroadenoma malignant ependymoma pancreatic intraductal papillary-mucinous neoplasm pancreatic ductal adenocarcinoma pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.