2GSL | pdb_00002gsl

X-Ray Crystal Structure of Protein FN1578 from Fusobacterium nucleatum. Northeast Structural Genomics Consortium Target NR1.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	RNase III domain-like	8086882	3001839	SCOP2B (2022-06-29)
D	SCOP2 Family	RNase III catalytic domain-like	8086881	4002876	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	RNase III domain-like	8086882	3001839	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	RNase III domain-like	8086882	3001839	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RNase III domain-like	8086882	3001839	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	RNase III domain-like	8086882	3001839	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	RNase III domain-like	8086882	3001839	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Ribonuclease_3	e2gslC1	A: alpha arrays	X: RNase III catalytic domain-like (From Topology)	H: RNase III catalytic domain-like (From Topology)	T: RNase III catalytic domain-like	F: Ribonuclease_3	ECOD (1.6)
D	Ribonuclease_3	e2gslD1	A: alpha arrays	X: RNase III catalytic domain-like (From Topology)	H: RNase III catalytic domain-like (From Topology)	T: RNase III catalytic domain-like	F: Ribonuclease_3	ECOD (1.6)
A	Ribonuclease_3	e2gslA1	A: alpha arrays	X: RNase III catalytic domain-like (From Topology)	H: RNase III catalytic domain-like (From Topology)	T: RNase III catalytic domain-like	F: Ribonuclease_3	ECOD (1.6)
B	Ribonuclease_3	e2gslB1	A: alpha arrays	X: RNase III catalytic domain-like (From Topology)	H: RNase III catalytic domain-like (From Topology)	T: RNase III catalytic domain-like	F: Ribonuclease_3	ECOD (1.6)
E	Ribonuclease_3	e2gslE1	A: alpha arrays	X: RNase III catalytic domain-like (From Topology)	H: RNase III catalytic domain-like (From Topology)	T: RNase III catalytic domain-like	F: Ribonuclease_3	ECOD (1.6)
F	Ribonuclease_3	e2gslF1	A: alpha arrays	X: RNase III catalytic domain-like (From Topology)	H: RNase III catalytic domain-like (From Topology)	T: RNase III catalytic domain-like	F: Ribonuclease_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.10.1520.10	Mainly Alpha	Orthogonal Bundle	Ribonuclease iii, N-terminal Endonuclease Domain	Chain A	CATH (4.3.0)
D	1.10.1520.10	Mainly Alpha	Orthogonal Bundle	Ribonuclease iii, N-terminal Endonuclease Domain	Chain A	CATH (4.3.0)
A	1.10.1520.10	Mainly Alpha	Orthogonal Bundle	Ribonuclease iii, N-terminal Endonuclease Domain	Chain A	CATH (4.3.0)
B	1.10.1520.10	Mainly Alpha	Orthogonal Bundle	Ribonuclease iii, N-terminal Endonuclease Domain	Chain A	CATH (4.3.0)
E	1.10.1520.10	Mainly Alpha	Orthogonal Bundle	Ribonuclease iii, N-terminal Endonuclease Domain	Chain A	CATH (4.3.0)
F	1.10.1520.10	Mainly Alpha	Orthogonal Bundle	Ribonuclease iii, N-terminal Endonuclease Domain	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00636	Ribonuclease III domain (Ribonuclease_3)	Ribonuclease III domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Hypothetical protein	ribonuclease III activity double-stranded RNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity catalytic activity	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR008226	Mini-ribonuclease 3 family	Family
A, B, C, D, E A, B, C, D, E, F	IPR000999	Ribonuclease III domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036389	Ribonuclease III, endonuclease domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.