Annotations: 2GF5

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2gf5a1	All alpha proteins	DEATH domain	DEATH domain	DEATH domain, DD	FADD (Mort1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2gf5a2	All alpha proteins	DEATH domain	DEATH domain	DEATH effector domain, DED	FADD (Mort1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2gf5a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DEATH domain, DD	8029452	4000378	SCOP2 (2022-06-29)
A	SCOP2 Family	DEATH effector domain, DED	8029454	4001934	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DEATH domain	8041831	3000069	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DEATH domain	8041833	3000069	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Death	e2gf5A1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
A	DED	e2gf5A2	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: DED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00531	Death domain (Death)	Death domain		Domain
A	PF01335	Death effector domain (DED)	Death effector domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	FADD protein	protein-macromolecule adaptor activity molecular adaptor activity protein binding binding enzyme binding protease binding caspase binding protein-containing complex binding signaling receptor binding cytokine receptor binding tumor necrosis factor receptor superfamily binding death receptor binding identical protein binding signaling adaptor activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding enzyme binding protease binding caspase binding protein-containing complex binding signaling receptor binding cytokine receptor binding tumor necrosis factor receptor superfamily binding death receptor binding identical protein binding signaling adaptor activity death effector domain binding protein domain specific binding receptor serine/threonine kinase binding tumor necrosis factor receptor binding	developmental process immune system development multicellular organism development multicellular organismal process lymph node development immune system process animal organ development anatomical structure development hematopoietic or lymphoid organ development system development regulation of biological process response to stimulus immune response regulation of adaptive immune response developmental process immune system development multicellular organism development multicellular organismal process lymph node development immune system process animal organ development anatomical structure development hematopoietic or lymphoid organ development system development regulation of biological process response to stimulus immune response regulation of adaptive immune response biological regulation positive regulation of biological process adaptive immune response positive regulation of response to stimulus regulation of response to stimulus positive regulation of immune response regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process regulation of cellular process homeostatic process leukocyte apoptotic process negative regulation of biological process regulation of programmed cell death lymphocyte apoptotic process negative regulation of leukocyte apoptotic process T cell homeostasis regulation of activation-induced cell death of T cells activation-induced cell death of T cells negative regulation of cellular process regulation of T cell apoptotic process negative regulation of activation-induced cell death of T cells regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of T cell apoptotic process negative regulation of apoptotic process multicellular organismal-level homeostasis leukocyte homeostasis negative regulation of immune system process cellular process homeostasis of number of cells T cell apoptotic process apoptotic process lymphocyte homeostasis programmed cell death negative regulation of lymphocyte apoptotic process positive regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus cellular response to stimulus cell surface receptor signaling pathway signaling extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway signal transduction positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction regulation of type I interferon-mediated signaling pathway response to cytokine regulation of signal transduction interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus regulation of innate immune response regulation of response to cytokine stimulus response to chemical positive regulation of defense response response to type I interferon regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus positive regulation of type I interferon-mediated signaling pathway positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway positive regulation of response to external stimulus regulation of response to stress regulation of signaling positive regulation of innate immune response regulation of cytokine-mediated signaling pathway response to peptide type I interferon-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis execution phase of apoptosis necroptotic process programmed necrotic cell death necroptotic signaling pathway extrinsic apoptotic signaling pathway via death domain receptors cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation cell differentiation T cell differentiation leukocyte differentiation signal transduction in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand positive regulation of interleukin-8 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process regulation of multicellular organismal process regulation of biosynthetic process interleukin-8 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process regulation of interleukin-8 production positive regulation of protein metabolic process regulation of protein metabolic process primary metabolic process regulation of primary metabolic process regulation of proteolysis proteolysis positive regulation of proteolysis protein metabolic process spleen development myeloid leukocyte differentiation regulation of leukocyte differentiation regulation of developmental process regulation of cell differentiation regulation of cell development positive regulation of developmental process positive regulation of cell differentiation positive regulation of hemopoiesis regulation of macrophage differentiation regulation of multicellular organismal development regulation of myeloid cell differentiation positive regulation of cell development macrophage differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of macrophage differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation protein-containing complex organization death-inducing signaling complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex assembly cellular component organization or biogenesis adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of immune effector process T cell mediated immunity positive regulation of leukocyte mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of leukocyte mediated cytotoxicity leukocyte mediated immunity positive regulation of immune effector process regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity regulation of cell killing positive regulation of cell killing cell killing defense response to virus response to virus kidney development renal system development positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription positive regulation of canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction behavior adult behavior behavioral response to cocaine response to oxygen-containing compound response to nitrogen compound response to cocaine response to alkaloid gland development thymus development neuron apoptotic process motor neuron apoptotic process positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway negative regulation of necroptotic process regulation of necroptotic process negative regulation of programmed necrotic cell death regulation of programmed necrotic cell death positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion leukocyte proliferation leukocyte cell-cell adhesion activated T cell proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus positive regulation of locomotion regulation of cell motility regulation of CD8-positive, alpha-beta T cell extravasation positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation CD8-positive, alpha-beta T cell extravasation regulation of lymphocyte migration positive regulation of cell migration positive regulation of T cell extravasation positive regulation of cell motility regulation of cell migration cellular extravasation positive regulation of mononuclear cell migration regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation regulation of T cell extravasation cell migration cell motility regulation of mononuclear cell migration locomotion positive regulation of lymphocyte migration T cell extravasation regulation of leukocyte migration positive regulation of T cell migration lymphocyte migration CD8-positive, alpha-beta cytotoxic T cell extravasation positive regulation of leukocyte migration leukocyte migration positive regulation of CD8-positive, alpha-beta T cell extravasation regulation of locomotion regulation of T cell migration mononuclear cell migration T cell migration regulation of cellular extravasation positive regulation of cellular extravasation regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production TRAIL-activated apoptotic signaling pathway regulation of type II interferon production type II interferon production positive regulation of type II interferon production	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell body cell periphery plasma membrane membrane protein-containing complex plasma membrane protein complex death-inducing signaling complex membrane protein complex CD95 death-inducing signaling complex ripoptosome cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell body cell periphery plasma membrane membrane protein-containing complex plasma membrane protein complex death-inducing signaling complex membrane protein complex CD95 death-inducing signaling complex ripoptosome catalytic complex cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR049634	FADD, vertebrates	Family
A	IPR000488	Death domain	Domain
A	IPR001875	Death effector domain	Domain
A	IPR016729	FAS-associated death domain protein	Family
A	IPR011029	Death-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13158	FADD-related immunodeficiency Neoplasm Metastasis coloboma pancreatic intraductal papillary-mucinous neoplasm oculootodental syndrome psoriasis glioblastoma ovarian cancer X-linked mixed deafness with perilymphatic gusher

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.