2G6Z | pdb_00002g6z

Crystal structure of human DUSP5

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2g6za1	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2g6za2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2g6zb_	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2g6zc1	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2g6zc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8067112	3000304	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8067112	3000304	SCOP2B (2022-06-29)
C	SCOP2 Family	Dual specificity phosphatase-like	8067111	4000437	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	(Phosphotyrosine protein) phosphatases II	8067112	3000304	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DSPc	e2g6zA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: DSPc	ECOD (1.6)
B	DSPc	e2g6zB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: DSPc	ECOD (1.6)
C	DSPc	e2g6zC1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: DSPc	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)
B	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)
C	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00782	Dual specificity phosphatase, catalytic domain (DSPc)	Dual specificity phosphatase, catalytic domain	Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Dual specificity protein phosphatase 5	phosphoric ester hydrolase activity phosphoprotein phosphatase activity non-membrane spanning protein tyrosine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXY142 phosphatase activity histone H2AXS140 phosphatase activity protein serine/threonine phosphatase activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity non-membrane spanning protein tyrosine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXY142 phosphatase activity histone H2AXS140 phosphatase activity protein serine/threonine phosphatase activity RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat phosphatase activity RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity myosin phosphatase activity RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity protein tyrosine/serine/threonine phosphatase activity MAP kinase serine/threonine phosphatase activity MAP kinase phosphatase activity protein tyrosine/threonine phosphatase activity MAP kinase tyrosine phosphatase activity protein tyrosine phosphatase activity, metal-dependent RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity calmodulin-dependent protein phosphatase activity calcium-dependent protein serine/threonine phosphatase activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade cellular process ERK1 and ERK2 cascade signal transduction protein dephosphorylation cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade cellular process ERK1 and ERK2 cascade signal transduction protein dephosphorylation dephosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction negative regulation of cell communication regulation of intracellular signal transduction negative regulation of cellular process regulation of signaling negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction regulation of response to stimulus regulation of cell communication negative regulation of MAPK cascade peptidyl-tyrosine dephosphorylation developmental process multicellular organismal process formation of primary germ layer embryonic morphogenesis tissue development embryo development gastrulation anatomical structure morphogenesis multicellular organism development endoderm development anatomical structure development anatomical structure formation involved in morphogenesis endoderm formation peptidyl-threonine dephosphorylation	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR001763	Rhodanese-like domain	Domain
A, B, C	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
A, B, C	IPR000340	Dual specificity phosphatase, catalytic domain	Domain
A, B, C	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A, B, C	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A, B, C	IPR036873	Rhodanese-like domain superfamily	Homologous Superfamily
A, B, C	IPR008343	Mitogen-activated protein (MAP) kinase phosphatase	Family
A, B, C	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A, B, C	IPR020422	Dual specificity protein phosphatase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q16690	hypertensive disorder pituitary cancer spina bifida type 2 diabetes mellitus breast cancer cutaneous lupus erythematosus gastric carcinoma invasive ductal breast carcinoma malignant ependymoma MALT lymphoma ovarian cancer plasma cell myeloma subependymal giant cell astrocytoma congestive heart failure ductal breast carcinoma in situ hypertensive disorder pituitary cancer spina bifida type 2 diabetes mellitus breast cancer cutaneous lupus erythematosus gastric carcinoma invasive ductal breast carcinoma malignant ependymoma MALT lymphoma ovarian cancer plasma cell myeloma subependymal giant cell astrocytoma congestive heart failure ductal breast carcinoma in situ lung adenocarcinoma malignant mesothelioma medulloblastoma pancreatic ductal adenocarcinoma Sjogren syndrome transitional cell carcinoma Crohn disease esophageal adenocarcinoma interstitial cystitis lung cancer malignant pancreatic neoplasm oligodendroglioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.