2E6B | pdb_00002e6b

Crystal structure of the stationary phase survival protein SurE from Thermus thermophilus HB8 in complex with magnesium and tungstate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2e6ba_	Alpha and beta proteins (a/b)	SurE-like	SurE-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
B	d2e6bb_	Alpha and beta proteins (a/b)	SurE-like	SurE-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
C	d2e6bc_	Alpha and beta proteins (a/b)	SurE-like	SurE-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
D	d2e6bd_	Alpha and beta proteins (a/b)	SurE-like	SurE-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SurE-like	8083756	3000878	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SurE-like	8083756	3000878	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SurE-like	8083756	3000878	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SurE-like	8083756	3000878	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SurE	e2e6bA1	A: a/b three-layered sandwiches	X: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	H: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	T: SurE-like/CoA-transferase family III (CaiB/BaiF)	F: SurE	ECOD (1.6)
B	SurE	e2e6bB1	A: a/b three-layered sandwiches	X: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	H: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	T: SurE-like/CoA-transferase family III (CaiB/BaiF)	F: SurE	ECOD (1.6)
C	SurE	e2e6bC1	A: a/b three-layered sandwiches	X: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	H: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	T: SurE-like/CoA-transferase family III (CaiB/BaiF)	F: SurE	ECOD (1.6)
D	SurE	e2e6bD1	A: a/b three-layered sandwiches	X: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	H: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	T: SurE-like/CoA-transferase family III (CaiB/BaiF)	F: SurE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1210.10	Alpha Beta	3-Layer(aba) Sandwich	Stationary-phase Survival Protein Sure Homolog	Chain: A,	CATH (4.3.0)
B	3.40.1210.10	Alpha Beta	3-Layer(aba) Sandwich	Stationary-phase Survival Protein Sure Homolog	Chain: A,	CATH (4.3.0)
C	3.40.1210.10	Alpha Beta	3-Layer(aba) Sandwich	Stationary-phase Survival Protein Sure Homolog	Chain: A,	CATH (4.3.0)
D	3.40.1210.10	Alpha Beta	3-Layer(aba) Sandwich	Stationary-phase Survival Protein Sure Homolog	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01975	Survival protein SurE (SurE)	Survival protein SurE	E. coli cells with the surE gene disrupted are found to survive poorly in stationary phase [1]. It is suggested that SurE may be involved in stress response. Yeast also contains a member of the family Swiss:P38254. Swiss:P30887 can complement a mut ...	E. coli cells with the surE gene disrupted are found to survive poorly in stationary phase [1]. It is suggested that SurE may be involved in stress response. Yeast also contains a member of the family Swiss:P38254. Swiss:P30887 can complement a mutation in acid phosphatase, suggesting that members of this family could be phosphatases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	5'-nucleotidase surE	phosphoric ester hydrolase activity nucleotidase activity 3'-nucleotidase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity pyrophosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides exopolyphosphatase activity hydrolase activity, acting on acid anhydrides binding nucleoside phosphate binding nucleotide binding phosphoric ester hydrolase activity nucleotidase activity 3'-nucleotidase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity pyrophosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides exopolyphosphatase activity hydrolase activity, acting on acid anhydrides binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding cation binding ion binding metal ion binding	-	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR030048	Survival protein SurE	Family
A, B, C, D	IPR002828	Survival protein SurE-like phosphatase/nucleotidase	Domain
A, B, C, D	IPR036523	SurE-like phosphatase/nucleotidase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.