1U7P | pdb_00001u7p

X-ray Crystal Structure of the Hypothetical Phosphotyrosine Phosphatase MDP-1 of the Haloacid Dehalogenase Superfamily

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1u7pa_	Alpha and beta proteins (a/b)	HAD-like	HAD-like	Magnesium-dependent phosphatase-1, Mdp1	Magnesium-dependent phosphatase-1, Mdp1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1u7pb_	Alpha and beta proteins (a/b)	HAD-like	HAD-like	Magnesium-dependent phosphatase-1, Mdp1	Magnesium-dependent phosphatase-1, Mdp1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d1u7pc_	Alpha and beta proteins (a/b)	HAD-like	HAD-like	Magnesium-dependent phosphatase-1, Mdp1	Magnesium-dependent phosphatase-1, Mdp1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d1u7pd_	Alpha and beta proteins (a/b)	HAD-like	HAD-like	Magnesium-dependent phosphatase-1, Mdp1	Magnesium-dependent phosphatase-1, Mdp1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Magnesium-dependent phosphatase-1, Mdp1	8030428	4003405	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HAD-like	8042807	3001890	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	HAD-like	8042807	3001890	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	HAD-like	8042807	3001890	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HAD-like	8042807	3001890	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Acid_PPase	e1u7pA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Acid_PPase	ECOD (1.6)
B	Acid_PPase	e1u7pB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Acid_PPase	ECOD (1.6)
C	Acid_PPase	e1u7pC1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Acid_PPase	ECOD (1.6)
D	Acid_PPase	e1u7pD1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Acid_PPase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
B	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
C	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
D	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF12689	Acid Phosphatase (Acid_PPase)	Acid Phosphatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	magnesium-dependent phosphatase-1	phosphoric ester hydrolase activity phosphoprotein phosphatase activity non-membrane spanning protein tyrosine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXY142 phosphatase activity protein tyrosine phosphatase activity, metal-dependent cation binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity non-membrane spanning protein tyrosine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXY142 phosphatase activity protein tyrosine phosphatase activity, metal-dependent cation binding ion binding binding metal ion binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR035679	Magnesium-dependent phosphatase-1, eukaryotic-type	Family
A, B, C, D	IPR010036	Magnesium-dependent phosphatase-1, eukaryotic/archaeal-type	Family
A, B, C, D	IPR036412	HAD-like superfamily	Homologous Superfamily
A, B, C, D	IPR023214	HAD superfamily	Homologous Superfamily
A, B, C, D	IPR010033	HAD-superfamily phosphatase, subfamily IIIC	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.