1T0B | pdb_00001t0b

Structure of ThuA-like protein from Bacillus stearothermophilus

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1t0ba_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	ThuA-like	GK2113 homologue	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)
B	d1t0bb_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	ThuA-like	GK2113 homologue	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)
C	d1t0bc_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	ThuA-like	GK2113 homologue	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)
D	d1t0bd_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	ThuA-like	GK2113 homologue	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)
E	d1t0be_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	ThuA-like	GK2113 homologue	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)
F	d1t0bf_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	ThuA-like	GK2113 homologue	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)
G	d1t0bg_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	ThuA-like	GK2113 homologue	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)
H	d1t0bh_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	ThuA-like	GK2113 homologue	(Geobacillus stearothermophilus ) [TaxId: 1422 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	ThuA-like	8027481	4002076	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Class I glutamine amidotransferase-like	8039860	3001405	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Class I glutamine amidotransferase-like	8039860	3001405	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Class I glutamine amidotransferase-like	8039860	3001405	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Class I glutamine amidotransferase-like	8039860	3001405	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Class I glutamine amidotransferase-like	8039860	3001405	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Class I glutamine amidotransferase-like	8039860	3001405	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Class I glutamine amidotransferase-like	8039860	3001405	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Class I glutamine amidotransferase-like	8039860	3001405	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ThuA	e1t0bA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: ThuA	ECOD (1.6)
B	ThuA	e1t0bB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: ThuA	ECOD (1.6)
C	ThuA	e1t0bC1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: ThuA	ECOD (1.6)
D	ThuA	e1t0bD1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: ThuA	ECOD (1.6)
E	ThuA	e1t0bE1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: ThuA	ECOD (1.6)
F	ThuA	e1t0bF1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: ThuA	ECOD (1.6)
G	ThuA	e1t0bG1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: ThuA	ECOD (1.6)
H	ThuA	e1t0bH1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: ThuA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)
B	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)
C	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)
D	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)
E	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)
F	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)
G	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)
H	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF06283	Trehalose utilisation (ThuA)	Trehalose utilisation	This family consists of several bacterial ThuA-like proteins. ThuA appears to be involved in utilisation of trehalose [1]. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmi ...	This family consists of several bacterial ThuA-like proteins. ThuA appears to be involved in utilisation of trehalose [1]. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium [2]. ThuA is involved in the conversion of of disaccharides to their respective 3-keto derivatives [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	ThuA-like protein	cation binding ion binding binding metal ion binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR029062	Class I glutamine amidotransferase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR029010	ThuA-like domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR009381	Trehalose catabolism protein, ThuA, prokaryote	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.