1SV1 | pdb_00001sv1

NMR structure of the ThKaiA180C-CIIABD complex (25-structure ensemble)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1sv1a1	All alpha proteins	KaiA/RbsU domain	KaiA/RbsU domain	Circadian clock protein KaiA, C-terminal domain	Circadian clock protein KaiA, C-terminal domain	(Thermosynechococcus vestitus BP-1 ) [TaxId: 197221 ],	SCOPe (2.08)
A	d1sv1a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Thermosynechococcus vestitus BP-1 ) [TaxId: 197221 ],	SCOPe (2.08)
B	d1sv1b1	All alpha proteins	KaiA/RbsU domain	KaiA/RbsU domain	Circadian clock protein KaiA, C-terminal domain	Circadian clock protein KaiA, C-terminal domain	(Thermosynechococcus vestitus BP-1 ) [TaxId: 197221 ],	SCOPe (2.08)
B	d1sv1b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Thermosynechococcus vestitus BP-1 ) [TaxId: 197221 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	KaiA/RbsU domain	8041136	3000938	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	KaiA/RbsU domain	8041136	3000938	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KaiA	e1sv1A1	A: alpha arrays	X: KaiA/RbsU domain-like	H: KaiA/RbsU domain (From Topology)	T: KaiA/RbsU domain	F: KaiA	ECOD (1.6)
B	KaiA	e1sv1B1	A: alpha arrays	X: KaiA/RbsU domain-like	H: KaiA/RbsU domain (From Topology)	T: KaiA/RbsU domain	F: KaiA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1240.30	Mainly Alpha	Orthogonal Bundle	Methyltransferase, Methionine Synthase (B12-binding Domains)	Chain A, domain 1	CATH (4.3.0)
B	1.10.1240.30	Mainly Alpha	Orthogonal Bundle	Methyltransferase, Methionine Synthase (B12-binding Domains)	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07688	KaiA C-terminal domain (KaiA)	KaiA C-terminal domain	The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. The overall fold of the KaiA C-terminal domain is that of a four-helix bundle, which forms a dimer in the known structure [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Circadian clock protein KaiA	identical protein binding protein binding binding	rhythmic process circadian rhythm	-
C, D	Circadian clock protein KaiC	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity histone H3S57 kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H3 kinase activity histone modifying activity catalytic activity histone kinase activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity histone H3S57 kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H3 kinase activity histone modifying activity catalytic activity histone kinase activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity ATP-dependent activity histone H2AS121 kinase activity histone H2A kinase activity ATP-dependent H3-H4 histone complex chaperone activity histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity molecular carrier activity protein serine/threonine/tyrosine kinase activity Rho-dependent protein serine/threonine kinase activity AMP-activated protein kinase activity cohesin loader activity DNA clamp loader activity histone H2AT120 kinase activity ATP-dependent H2AZ histone chaperone activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding DNA binding nucleic acid binding histone H3T11 kinase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides histone H3S28 kinase activity histone H3T6 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2B kinase activity histone H2BS36 kinase activity histone H3T3 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity histone H2BS14 kinase activity identical protein binding protein binding	rhythmic process circadian rhythm regulation of biological process biological regulation regulation of circadian rhythm protein phosphorylation protein autophosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process rhythmic process circadian rhythm regulation of biological process biological regulation regulation of circadian rhythm protein phosphorylation protein autophosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011006	CheY-like superfamily	Homologous Superfamily
A, B	IPR011648	Circadian clock oscillator protein KaiA	Family
A, B	IPR020844	Circadian clock protein KaiA, N-terminal	Domain
A, B	IPR017944	KaiA/RbsU helical domain superfamily	Homologous Superfamily
A, B	IPR020856	Circadian clock oscillator protein KaiA, C-terminal	Domain
C, D	IPR030665	Circadian clock protein kinase KaiC	Family
C, D	IPR010624	KaiC domain	Domain
C, D	IPR013503	Circadian clock KaiC, bacteria	Family
C, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C, D	IPR014774	KaiC-like domain	Domain
C, D	IPR047222	Circadian clock protein kinase KaiC, C-terminal domain	Domain
C, D	IPR051347	Circadian clock KaiC-related	Family
C, D	IPR047221	Circadian clock protein kinase KaiC, N-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.