1RH2

RECOMBINANT HUMAN INTERFERON-ALPHA 2B

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
IMGT Antibody Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1rh2a_	All alpha proteins	4-helical cytokines	4-helical cytokines	Interferons/interleukin-10 (IL-10)	Interferon-alpha 2b	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1rh2b_	All alpha proteins	4-helical cytokines	4-helical cytokines	Interferons/interleukin-10 (IL-10)	Interferon-alpha 2b	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1rh2c_	All alpha proteins	4-helical cytokines	4-helical cytokines	Interferons/interleukin-10 (IL-10)	Interferon-alpha 2b	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1rh2d_	All alpha proteins	4-helical cytokines	4-helical cytokines	Interferons/interleukin-10 (IL-10)	Interferon-alpha 2b	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1rh2e_	All alpha proteins	4-helical cytokines	4-helical cytokines	Interferons/interleukin-10 (IL-10)	Interferon-alpha 2b	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1rh2f_	All alpha proteins	4-helical cytokines	4-helical cytokines	Interferons/interleukin-10 (IL-10)	Interferon-alpha 2b	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	4-helical cytokines	8037129	3001717	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	4-helical cytokines	8037129	3001717	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	4-helical cytokines	8037129	3001717	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	4-helical cytokines	8037129	3001717	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Interferon	e1rh2A1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: Interferon	ECOD (1.6)
B	Interferon	e1rh2B1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: Interferon	ECOD (1.6)
C	Interferon	e1rh2C1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: Interferon	ECOD (1.6)
D	Interferon	e1rh2D1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: Interferon	ECOD (1.6)
E	Interferon	e1rh2E1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: Interferon	ECOD (1.6)
F	Interferon	e1rh2F1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: Interferon	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, B, C, D, E A, B, C, D, E, F	IFNA2 (Interferon alpha-2)	IFNA2	Homo sapiens (human)	IFNA2*02	R-LIKE-DOMAIN IFNA2 (Pr24-188)	RPI	IFNA2	IMGT (202446-0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	INTERFERON-ALPHA 2B	protein-containing complex binding binding protein binding type I interferon receptor binding signaling receptor binding cytokine receptor binding molecular function activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular response to stimulus response to stimulus cell surface receptor signaling pathway signaling response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus signal transduction developmental process multicellular organismal process cellular developmental process hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation immune system process anatomical structure development leukocyte differentiation immune response adaptive immune response natural killer cell activation cell activation involved in immune response immune effector process natural killer cell activation involved in immune response leukocyte activation involved in immune response lymphocyte activation involved in immune response humoral immune response cell surface receptor signaling pathway via STAT response to dsRNA response to nitrogen compound response to exogenous dsRNA response to organic cyclic compound regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation regulation of cell differentiation regulation of cell development negative regulation of cell adhesion multicellular organism development negative regulation of T cell differentiation T cell activation T cell differentiation regulation of immune system process negative regulation of hemopoiesis negative regulation of leukocyte differentiation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of lymphocyte differentiation negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of developmental process negative regulation of lymphocyte activation leukocyte cell-cell adhesion regulation of T cell differentiation cell adhesion cell-cell adhesion regulation of multicellular organismal process regulation of cell-cell adhesion negative regulation of cell differentiation regulation of lymphocyte differentiation regulation of multicellular organismal development negative regulation of developmental process regulation of cell adhesion regulation of T cell activation negative regulation of cell activation negative regulation of cell development negative regulation of immune system process regulation of hemopoiesis regulation of lymphocyte activation negative regulation of interleukin-5 production regulation of interleukin-5 production regulation of cytokine production cytokine production interleukin-5 production negative regulation of cytokine production negative regulation of gene expression apoptotic process cell death programmed cell death cell-cell signaling biological process involved in interspecies interaction between organisms negative regulation of viral life cycle viral life cycle modulation by symbiont of entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of viral entry into host cell regulation of viral life cycle regulation of viral process negative regulation of viral process symbiont entry into host cell viral process symbiont entry into host negative regulation of viral entry into host cell regulation of biological process involved in symbiotic interaction cell population proliferation B cell proliferation leukocyte proliferation mononuclear cell proliferation lymphocyte proliferation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of immune effector process T cell mediated immunity T-helper 2 cell cytokine production negative regulation of lymphocyte mediated immunity T cell cytokine production type 2 immune response regulation of T-helper 2 cell cytokine production regulation of type 2 immune response leukocyte mediated immunity negative regulation of T-helper 2 cell cytokine production regulation of T cell mediated immunity negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response regulation of adaptive immune response negative regulation of immune response negative regulation of immune effector process negative regulation of adaptive immune response negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of type 2 immune response regulation of leukocyte mediated immunity negative regulation of production of molecular mediator of immune response regulation of response to stimulus regulation of immune response regulation of production of molecular mediator of immune response negative regulation of T cell mediated immunity negative regulation of T cell cytokine production regulation of T cell cytokine production CD4-positive, alpha-beta T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains cytokine production involved in immune response production of molecular mediator of immune response negative regulation of response to stimulus regulation of lymphocyte mediated immunity negative regulation of leukocyte mediated immunity defense response response to stress inflammatory response T cell activation involved in immune response response to other organism defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to external biotic stimulus response to virus interleukin-13 production negative regulation of interleukin-13 production regulation of interleukin-13 production cellular response to virus positive regulation of phosphorylation regulation of peptidyl-serine phosphorylation regulation of signal transduction positive regulation of phosphate metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification regulation of receptor signaling pathway via JAK-STAT positive regulation of macromolecule metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation positive regulation of peptidyl-serine phosphorylation of STAT protein protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process serine phosphorylation of STAT protein macromolecule modification regulation of phosphorus metabolic process regulation of receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-serine phosphorylation of STAT protein peptidyl-serine modification positive regulation of protein modification process peptidyl-serine phosphorylation protein metabolic process positive regulation of cellular process regulation of signaling positive regulation of peptidyl-serine phosphorylation regulation of cell communication regulation of phosphorylation cell surface receptor signaling pathway via JAK-STAT interferon-mediated signaling pathway cellular response to type I interferon innate immune response type I interferon-mediated signaling pathway response to type I interferon	cell periphery extracellular matrix cellular anatomical structure external encapsulating structure collagen-containing extracellular matrix extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR000471	Interferon alpha/beta/delta	Family
A, B, C, D, E A, B, C, D, E, F	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P01563	hepatitis C virus infection chronic myelogenous leukemia, BCR-ABL1 positive plasma cell myeloma renal cell carcinoma essential thrombocythemia neutropenia transitional cell carcinoma Vogt-Koyanagi-Harada disease Stevens-Johnson syndrome thrombocytopenia melanoma leukopenia follicular lymphoma glioblastoma acquired polycythemia vera hepatitis C virus infection chronic myelogenous leukemia, BCR-ABL1 positive plasma cell myeloma renal cell carcinoma essential thrombocythemia neutropenia transitional cell carcinoma Vogt-Koyanagi-Harada disease Stevens-Johnson syndrome thrombocytopenia melanoma leukopenia follicular lymphoma glioblastoma acquired polycythemia vera squamous cell carcinoma adult T-cell leukemia/lymphoma epithelioid hemangioendothelioma hypertriglyceridemia Fatigue sarcomatoid renal cell carcinoma urinary bladder cancer somatization disorder hepatitis anemia stomatitis thyroid adenoma melancholia Raynaud disease endogenous depression Hodgkins lymphoma myocardial infarction retinal detachment intestinal perforation chronic hepatitis B virus infection collecting duct carcinoma giant cell glioblastoma somatoform disorder papillary renal cell carcinoma hepatitis B virus infection substance withdrawal syndrome chromophobe renal cell carcinoma retinal disease kidney failure colorectal cancer skin disease hemolytic anemia polyomavirus infectious disease pterygium anterior ischemic optic neuropathy thyroid gland carcinoma renal carcinoma myeloid neoplasm reticulum cell sarcoma neurotic disorder toxic epidermal necrolysis non-Hodgkin lymphoma colorectal carcinoma acute kidney failure pancreatic neoplasm acute T cell leukemia depressive disorder anxiety disorder Hodgkin's lymphoma, lymphocytic-histiocytic predominance cancer urinary bladder neoplasm cutaneous melanoma plasma cell neoplasm psychiatric disorder thyroid cancer drug-induced liver injury Hodgkin's lymphoma, mixed cellularity epilepsy Huntington disease familial polycythemia chronic hepatitis C virus infection nodular lymphocyte predominant Hodgkin lymphoma fatty liver disease sarcoidosis clear cell renal carcinoma lymphosarcoma malignant pancreatic neoplasm diarrheal disease Hodgkin's lymphoma, lymphocytic depletion

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.