Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Cd1kfyc_ Membrane and cell surface proteins and peptides Heme-binding four-helical bundle Fumarate reductase respiratory complex transmembrane subunits Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Fumarate reductase subunit FrdC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
G [auth O]d1kfyo_ Membrane and cell surface proteins and peptides Heme-binding four-helical bundle Fumarate reductase respiratory complex transmembrane subunits Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Fumarate reductase subunit FrdC (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1kfya1 All alpha proteins Spectrin repeat-like Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain Fumarate reductase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1kfya2 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain Fumarate reductase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1kfya3 Alpha and beta proteins (a+b) Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Fumarate reductase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
E [auth M]d1kfym1 All alpha proteins Spectrin repeat-like Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain Fumarate reductase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
E [auth M]d1kfym2 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain Fumarate reductase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
E [auth M]d1kfym3 Alpha and beta proteins (a+b) Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Fumarate reductase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Bd1kfyb1 All alpha proteins Globin-like alpha-helical ferredoxin Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain Fumarate reductase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Bd1kfyb2 Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) 2Fe-2S ferredoxin-like 2Fe-2S ferredoxin domains from multidomain proteins Fumarate reductase iron-sulfur protein, N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
F [auth N]d1kfyn1 All alpha proteins Globin-like alpha-helical ferredoxin Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain Fumarate reductase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
F [auth N]d1kfyn2 Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) 2Fe-2S ferredoxin-like 2Fe-2S ferredoxin domains from multidomain proteins Fumarate reductase iron-sulfur protein, N-terminal domain (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Dd1kfyd_ Membrane and cell surface proteins and peptides Heme-binding four-helical bundle Fumarate reductase respiratory complex transmembrane subunits Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Fumarate reductase subunit FrdD (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
H [auth P]d1kfyp_ Membrane and cell surface proteins and peptides Heme-binding four-helical bundle Fumarate reductase respiratory complex transmembrane subunits Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Fumarate reductase subunit FrdD (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
CSCOP2B SuperfamilyFumarate reductase respiratory complex transmembrane subunits 8040234 3000518 SCOP2B (2022-06-29)
G [auth O]SCOP2B SuperfamilyFumarate reductase respiratory complex transmembrane subunits 8040234 3000518 SCOP2B (2022-06-29)
ASCOP2B SuperfamilySuccinate dehydrogenase/fumarate reductase domain-like 8056076 3000054 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyL-aspartate oxidase C-terminal domain-like 8056077 3000021 SCOP2B (2022-06-29)
E [auth M]SCOP2B SuperfamilySuccinate dehydrogenase/fumarate reductase domain-like 8056076 3000054 SCOP2B (2022-06-29)
E [auth M]SCOP2B SuperfamilyL-aspartate oxidase C-terminal domain-like 8056077 3000021 SCOP2B (2022-06-29)
BSCOP2B Superfamilyalpha-helical ferredoxin 8003619 3000026 SCOP2B (2022-06-29)
BSCOP2B Superfamily2Fe-2S ferredoxin-like 8003622 3000113 SCOP2B (2022-06-29)
F [auth N]SCOP2B Superfamilyalpha-helical ferredoxin 8003619 3000026 SCOP2B (2022-06-29)
F [auth N]SCOP2B Superfamily2Fe-2S ferredoxin-like 8003622 3000113 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyFumarate reductase respiratory complex transmembrane subunits 8040223 3000518 SCOP2B (2022-06-29)
H [auth P]SCOP2B SuperfamilyFumarate reductase respiratory complex transmembrane subunits 8040223 3000518 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
CFumarate_red_Ce1kfyC1 A: alpha bundlesX: Transmembrane heme-binding four-helical bundle (From Homology)H: Transmembrane heme-binding four-helical bundleT: Fumarate reductase respiratory complex transmembrane subunitsF: Fumarate_red_CECOD (1.6)
G [auth O]Fumarate_red_Ce1kfyO1 A: alpha bundlesX: Transmembrane heme-binding four-helical bundle (From Homology)H: Transmembrane heme-binding four-helical bundleT: Fumarate reductase respiratory complex transmembrane subunitsF: Fumarate_red_CECOD (1.6)
ASucc_DH_flav_Ce1kfyA1 A: alpha bundlesX: Spectrin repeat-likeH: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domainF: Succ_DH_flav_CECOD (1.6)
AFAD_binding_2e1kfyA2 A: a+b complex topologyX: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domainF: FAD_binding_2ECOD (1.6)
AFAD_binding_3_1ste1kfyA3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: FAD_binding_3_1stECOD (1.6)
E [auth M]Succ_DH_flav_Ce1kfyM1 A: alpha bundlesX: Spectrin repeat-likeH: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domainF: Succ_DH_flav_CECOD (1.6)
E [auth M]FAD_binding_2e1kfyM2 A: a+b complex topologyX: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domainF: FAD_binding_2ECOD (1.6)
E [auth M]FAD_binding_3_1ste1kfyM3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: FAD_binding_3_1stECOD (1.6)
BFer4_8e1kfyB1 A: alpha arraysX: alpha-helical ferredoxin-likeH: alpha-helical ferredoxin (From Topology)T: alpha-helical ferredoxinF: Fer4_8ECOD (1.6)
BFer2_3e1kfyB2 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Fer2_3ECOD (1.6)
F [auth N]Fer4_8e1kfyN1 A: alpha arraysX: alpha-helical ferredoxin-likeH: alpha-helical ferredoxin (From Topology)T: alpha-helical ferredoxinF: Fer4_8ECOD (1.6)
F [auth N]Fer2_3e1kfyN2 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Fer2_3ECOD (1.6)
DFumarate_red_De1kfyD1 A: alpha bundlesX: Transmembrane heme-binding four-helical bundle (From Homology)H: Transmembrane heme-binding four-helical bundleT: Fumarate reductase respiratory complex transmembrane subunitsF: Fumarate_red_DECOD (1.6)
H [auth P]Fumarate_red_De1kfyP1 A: alpha bundlesX: Transmembrane heme-binding four-helical bundle (From Homology)H: Transmembrane heme-binding four-helical bundleT: Fumarate reductase respiratory complex transmembrane subunitsF: Fumarate_red_DECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
C1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunitCATH (4.3.0)
G [auth O]1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunitCATH (4.3.0)
A3.50.50.60 Alpha Beta 3-Layer(bba) Sandwich FAD/NAD(P)-binding domain FAD/NAD(P)-binding domainCATH (4.3.0)
A3.90.700.10 Alpha Beta Alpha-Beta Complex Flavocytochrome C3 Chain A, domain 1CATH (4.3.0)
A1.20.58.100 Mainly Alpha Up-down Bundle Methane Monooxygenase Hydroxylase Chain G, domain 1CATH (4.3.0)
A4.10.80.40 Few Secondary Structures Irregular Rhinovirus 14, subunit 4 succinate dehydrogenase protein domainCATH (4.3.0)
E [auth M]3.50.50.60 Alpha Beta 3-Layer(bba) Sandwich FAD/NAD(P)-binding domain FAD/NAD(P)-binding domainCATH (4.3.0)
E [auth M]3.90.700.10 Alpha Beta Alpha-Beta Complex Flavocytochrome C3 Chain A, domain 1CATH (4.3.0)
E [auth M]1.20.58.100 Mainly Alpha Up-down Bundle Methane Monooxygenase Hydroxylase Chain G, domain 1CATH (4.3.0)
E [auth M]4.10.80.40 Few Secondary Structures Irregular Rhinovirus 14, subunit 4 succinate dehydrogenase protein domainCATH (4.3.0)
B3.10.20.30 Alpha Beta Roll Ubiquitin-like (UB roll) Beta-grasp domainCATH (4.3.0)
B1.10.1060.10 Mainly Alpha Orthogonal Bundle Fumarate Reductase Iron-sulfur Protein Chain B, domain 2CATH (4.3.0)
F [auth N]3.10.20.30 Alpha Beta Roll Ubiquitin-like (UB roll) Beta-grasp domainCATH (4.3.0)
F [auth N]1.10.1060.10 Mainly Alpha Orthogonal Bundle Fumarate Reductase Iron-sulfur Protein Chain B, domain 2CATH (4.3.0)
D1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunitCATH (4.3.0)
H [auth P]1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunitCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
C,
G [auth O]
PF02300Fumarate reductase subunit C (Fumarate_red_C)Fumarate reductase subunit CFumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 15kD hy ...Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 15kD hydrophobic subunit C.
Domain
A,
E [auth M]
PF02910Fumarate reductase flavoprotein C-term (Succ_DH_flav_C)Fumarate reductase flavoprotein C-termThis family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases.Domain
A,
E [auth M]
PF00890FAD binding domain (FAD_binding_2)FAD binding domain- Family
B,
F [auth N]
PF130852Fe-2S iron-sulfur cluster binding domain (Fer2_3)2Fe-2S iron-sulfur cluster binding domainThe 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.Domain
B,
F [auth N]
PF132374Fe-4S dicluster domain (Fer4_10)4Fe-4S dicluster domainThis family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.Domain
D,
H [auth P]
PF02313Fumarate reductase subunit D (Fumarate_red_D)Fumarate reductase subunit DFumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 13kD hy ...Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 13kD hydrophobic subunit D.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
C,
G [auth O]
FUMARATE REDUCTASE 15 KDA HYDROPHOBIC PROTEIN
A,
E [auth M]
FUMARATE REDUCTASE FLAVOPROTEIN
B,
F [auth N]
Fumarate reductase iron-sulfur protein
D,
H [auth P]
FUMARATE REDUCTASE 13 KDA HYDROPHOBIC PROTEIN

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
C,
G [auth O]
IPR034804Fumarate reductase/succinate dehydrogenase, transmembrane subunitHomologous Superfamily
C,
G [auth O]
IPR003510Fumarate reductase, subunit CFamily
A,
E [auth M]
IPR015939Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminalDomain
A,
E [auth M]
IPR003952Fumarate reductase/succinate dehydrogenase, FAD-binding siteBinding Site
A,
E [auth M]
IPR037099Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamilyHomologous Superfamily
A,
E [auth M]
IPR036188FAD/NAD(P)-binding domain superfamilyHomologous Superfamily
A,
E [auth M]
IPR003953FAD-dependent oxidoreductase 2, FAD binding domainDomain
A,
E [auth M]
IPR030664FAD-dependent oxidoreductase SdhA/FrdA/AprAFamily
A,
E [auth M]
IPR005884Fumarate reductase, flavoprotein subunitFamily
A,
E [auth M]
IPR027477Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamilyHomologous Superfamily
A,
E [auth M]
IPR014006Succinate dehydrogenase/fumarate reductase, flavoprotein subunitFamily
B,
F [auth N]
IPR0010412Fe-2S ferredoxin-type iron-sulfur binding domainDomain
B,
F [auth N]
IPR0060582Fe-2S ferredoxin, iron-sulphur binding siteBinding Site
B,
F [auth N]
IPR004489Succinate dehydrogenase/fumarate reductase iron-sulphur proteinFamily
B,
F [auth N]
IPR0179004Fe-4S ferredoxin, iron-sulphur binding, conserved siteConserved Site
B,
F [auth N]
IPR012675Beta-grasp domain superfamilyHomologous Superfamily
B,
F [auth N]
IPR025192Succinate dehydogenase/fumarate reductase N-terminalDomain
B,
F [auth N]
IPR0360102Fe-2S ferredoxin-like superfamilyHomologous Superfamily
B,
F [auth N]
IPR009051Alpha-helical ferredoxinHomologous Superfamily
B,
F [auth N]
IPR0178964Fe-4S ferredoxin-type, iron-sulphur binding domainDomain
D,
H [auth P]
IPR034804Fumarate reductase/succinate dehydrogenase, transmembrane subunitHomologous Superfamily
D,
H [auth P]
IPR003418Fumarate reductase, subunit DFamily