Annotations: 1IYR

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1iyra_	All alpha proteins	C-terminal domain of DFF45/ICAD (DFF-C domain)	C-terminal domain of DFF45/ICAD (DFF-C domain)	C-terminal domain of DFF45/ICAD (DFF-C domain)	C-terminal domain of DFF45/ICAD (DFF-C domain)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	C-terminal domain of DFF45/ICAD (DFF-C domain)	8030236	4002364	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C-terminal domain of DFF45/ICAD (DFF-C domain)	8042615	3001144	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DFF-C	e1iyrA1	A: alpha arrays	X: HTH	H: C-terminal domain of DFF45/ICAD (From Topology)	T: C-terminal domain of DFF45/ICAD	F: DFF-C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1490.10	Mainly Alpha	Orthogonal Bundle	Dna Fragmentation Factor Alpha Subunit	Chain: A	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA FRAGMENTATION FACTOR ALPHA SUBUNIT	protein binding binding protein domain specific binding enzyme regulator activity catalytic activity, acting on a nucleic acid hydrolase activity enzyme inhibitor activity DNA nuclease activity deoxyribonuclease inhibitor activity molecular function inhibitor activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds molecular function regulator activity protein binding binding protein domain specific binding enzyme regulator activity catalytic activity, acting on a nucleic acid hydrolase activity enzyme inhibitor activity DNA nuclease activity deoxyribonuclease inhibitor activity molecular function inhibitor activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds molecular function regulator activity nuclease inhibitor activity catalytic activity protein folding chaperone	negative regulation of hydrolase activity regulation of cellular process regulation of catalytic activity negative regulation of deoxyribonuclease activity negative regulation of biological process negative regulation of catalytic activity regulation of primary metabolic process nucleobase-containing compound metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of biological process negative regulation of metabolic process negative regulation of hydrolase activity regulation of cellular process regulation of catalytic activity negative regulation of deoxyribonuclease activity negative regulation of biological process negative regulation of catalytic activity regulation of primary metabolic process nucleobase-containing compound metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of biological process negative regulation of metabolic process biological regulation negative regulation of molecular function primary metabolic process regulation of macromolecule metabolic process DNA metabolic process nucleic acid metabolic process regulation of molecular function regulation of hydrolase activity cellular process metabolic process negative regulation of DNA metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of nuclease activity regulation of DNA metabolic process catabolic process macromolecule catabolic process regulation of DNA catabolic process cellular component organization execution phase of apoptosis DNA catabolic process apoptotic nuclear changes cellular component organization or biogenesis regulation of apoptotic DNA fragmentation cellular component disassembly negative regulation of catabolic process regulation of catabolic process cell death negative regulation of apoptotic DNA fragmentation nucleobase-containing compound catabolic process apoptotic DNA fragmentation negative regulation of DNA catabolic process cellular component disassembly involved in execution phase of apoptosis nucleic acid catabolic process apoptotic process programmed cell death gene expression chaperone-mediated protein folding macromolecule biosynthetic process protein maturation protein folding biosynthetic process protein metabolic process positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process lymphocyte apoptotic process thymocyte apoptotic process leukocyte apoptotic process T cell apoptotic process negative regulation of programmed cell death negative regulation of execution phase of apoptosis regulation of execution phase of apoptosis negative regulation of apoptotic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle intracellular membraneless organelle chromatin chromosome protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003508	CIDE-N domain	Domain
A	IPR015121	DNA fragmentation factor 45kDa, middle domain	Domain
A	IPR017299	DNA fragmentation factor 45	Family
A	IPR027296	DNA fragmentation factor 45kDa, C-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O00273	breast carcinoma osteosarcoma estrogen-receptor negative breast cancer Pick disease lung cancer prostate carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.