Annotations: 1IUR

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1iura1	All alpha proteins	Long alpha-hairpin	Chaperone J-domain	Chaperone J-domain	Hypothetical protein KIAA0730	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1iura2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Chaperone J-domain	8023545	4000605	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Chaperone J-domain	8035925	3000721	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DnaJ,RNAse_Pc_like	e1iurA1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ,RNAse_Pc_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	KIAA0730 protein	protein binding binding Hsp70 protein binding protein-folding chaperone binding heat shock protein binding low-density lipoprotein particle receptor binding signaling receptor binding lipoprotein particle receptor binding protein-containing complex binding proteasome binding identical protein binding	regulation of biological process regulation of cellular process regulation of cellular component organization negative regulation of cellular component organization regulation of inclusion body assembly biological regulation negative regulation of biological process inclusion body assembly regulation of cellular component biogenesis cellular component biogenesis cellular component organization cellular component assembly negative regulation of cellular process cellular process regulation of biological process regulation of cellular process regulation of cellular component organization negative regulation of cellular component organization regulation of inclusion body assembly biological regulation negative regulation of biological process inclusion body assembly regulation of cellular component biogenesis cellular component biogenesis cellular component organization cellular component assembly negative regulation of cellular process cellular process cellular component organization or biogenesis negative regulation of inclusion body assembly protein folding biosynthetic process metabolic process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cell body fiber cell projection neuron projection plasma membrane bounded cell projection axon somatodendritic compartment membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cell body fiber cell projection neuron projection plasma membrane bounded cell projection axon somatodendritic compartment dendrite dendritic tree nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007842	HEPN domain	Domain
A	IPR052972	Sacsin chaperone regulator	Family
A	IPR000626	Ubiquitin-like domain	Domain
A	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily
A	IPR001623	DnaJ domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NZJ4	Charlevoix-Saguenay spastic ataxia progressive myoclonus epilepsy dentatorubral-pallidoluysian atrophy interstitial cystitis May-White Syndrome neurodegenerative disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sarcoidosis action myoclonus-renal failure syndrome astrocytic tumor Charcot-Marie-Tooth disease Crohn disease glioblastoma invasive ductal breast carcinoma medulloblastoma Charlevoix-Saguenay spastic ataxia progressive myoclonus epilepsy dentatorubral-pallidoluysian atrophy interstitial cystitis May-White Syndrome neurodegenerative disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sarcoidosis action myoclonus-renal failure syndrome astrocytic tumor Charcot-Marie-Tooth disease Crohn disease glioblastoma invasive ductal breast carcinoma medulloblastoma ovarian cancer pilocytic astrocytoma Alzheimer disease breast cancer gastric cancer intellectual disability lung cancer pancreatic intraductal papillary-mucinous carcinoma ulcerative colitis amyotrophic lateral sclerosis breast carcinoma colorectal cancer Emery-Dreifuss muscular dystrophy gastric carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.