Annotations: 1IQ3

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1iq3a1	All alpha proteins	EF Hand-like	EF-hand	Eps15 homology domain (EH domain)	Pob1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1iq3a2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Eps15 homology domain (EH domain)	8021773	4000946	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	EF-hand	8034153	3001983	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EF-hand_4	e1iq3A1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF12763	EH domain (EH)	EH domain	This entry represents the EH domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	RALBP1-INTERACTING PROTEIN (PARTNER OF RALBP1)	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis localization cellular localization transport establishment of localization in cell intracellular transport establishment of localization vesicle-mediated transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis localization cellular localization transport establishment of localization in cell intracellular transport establishment of localization vesicle-mediated transport endosomal transport cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication ERBB signaling pathway epidermal growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway import into cell endocytosis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR002048	EF-hand domain	Domain
A	IPR000261	EH domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8NFH8	breast carcinoma breast cancer oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma psoriasis adenoma glioblastoma large cell medulloblastoma malignant ependymoma Mammary Neoplasms myopathy osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer breast carcinoma breast cancer oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma psoriasis adenoma glioblastoma large cell medulloblastoma malignant ependymoma Mammary Neoplasms myopathy osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer Sjogren syndrome astrocytic tumor interstitial cystitis lung adenocarcinoma malignant glioma non-small cell lung carcinoma ovarian cancer Pick disease primitive neuroectodermal tumor subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor cystic fibrosis invasive ductal breast carcinoma lung cancer medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.