1I9R
STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Thera-SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | TNF | e1i9rA1 | A: beta sandwiches | X: jelly-roll | H: TNF-like (From Topology) | T: TNF-like | F: TNF | ECOD (1.6) |
B | TNF | e1i9rB1 | A: beta sandwiches | X: jelly-roll | H: TNF-like (From Topology) | T: TNF-like | F: TNF | ECOD (1.6) |
C | TNF | e1i9rC1 | A: beta sandwiches | X: jelly-roll | H: TNF-like (From Topology) | T: TNF-like | F: TNF | ECOD (1.6) |
E [auth L] | C1-set_4 | e1i9rL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
E [auth L] | V-set | e1i9rL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
G [auth M] | C1-set_4 | e1i9rM2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
G [auth M] | V-set | e1i9rM1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
I [auth Y] | C1-set_4 | e1i9rY2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
I [auth Y] | V-set | e1i9rY1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
D [auth H] | V-set_8 | e1i9rH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
D [auth H] | C1-set_1 | e1i9rH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
F [auth K] | V-set_8 | e1i9rK1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
F [auth K] | C1-set_1 | e1i9rK2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
H [auth X] | V-set_8 | e1i9rX1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
H [auth X] | C1-set_1 | e1i9rX2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.60.120.40 | Mainly Beta | Sandwich | Jelly Rolls | CATH (4.3.0) | |
B | 2.60.120.40 | Mainly Beta | Sandwich | Jelly Rolls | CATH (4.3.0) | |
C | 2.60.120.40 | Mainly Beta | Sandwich | Jelly Rolls | CATH (4.3.0) | |
E [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
G [auth M] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
I [auth Y] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
D [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
F [auth K] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
H [auth X] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
E [auth L], G [auth M], I [auth Y] | Humanized 5C8 neutralizing mAb, anti-CD40 ligand | L-KAPPA | Humanized (humanized) | IGKV3-11*01, IGKJ4*01, IGKJ4*02, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202447-0) |
D [auth H], F [auth K], H [auth X] | Humanized 5C8 neutralizing mAb, anti-CD40 ligand | VH-CH1 | Humanized (humanized) | IGHV1-46*01, IGHV1-46*03, IGHJ5*01, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202447-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
E [auth L], G [auth M], I [auth Y] | Light Chain | IGKV3D | Kappa | cd40 ligand | SAbDab (2024-11-29) |
D [auth H], F [auth K], H [auth X] | Heavy Chain | IGHV1 | - | cd40 ligand | SAbDab (2024-11-29) |
Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage
Chain | Name | Target | Provenance Source |
---|---|---|---|
E [auth L], G [auth M], I [auth Y] | Tegoprubart | CD40LG/CD154 | Therapeutic SAbDab (2024-11-29) |
D [auth H], F [auth K], H [auth X] | Tegoprubart | CD40LG/CD154 | Therapeutic SAbDab (2024-11-29) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00229 | TNF(Tumour Necrosis Factor) family (TNF) | TNF(Tumour Necrosis Factor) family | - | Domain | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR008983 | Tumour necrosis factor-like domain superfamily | Homologous Superfamily | |
IPR006052 | Tumour necrosis factor domain | Domain | |
IPR021184 | Tumour necrosis factor, conserved site | Conserved Site | |
IPR003263 | CD40 ligand | Family |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
P29965 | :