Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
D [auth H]d1i9rh1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth H]d1i9rh2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth K]d1i9rk1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth K]d1i9rk2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
H [auth X]d1i9rx1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
H [auth X]d1i9rx2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
E [auth L]d1i9rl1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
E [auth L]d1i9rl2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
G [auth M]d1i9rm1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
G [auth M]d1i9rm2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
I [auth Y]d1i9ry1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
I [auth Y]d1i9ry2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad1i9ra_ All beta proteins TNF-like TNF-like TNF-like Extracellular domain of CD40 ligand human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd1i9rb_ All beta proteins TNF-like TNF-like TNF-like Extracellular domain of CD40 ligand human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd1i9rc_ All beta proteins TNF-like TNF-like TNF-like Extracellular domain of CD40 ligand human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyTNF-like 8041217 3000061 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyTNF-like 8041217 3000061 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyTNF-like 8041217 3000061 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
D [auth H]V-set_8e1i9rH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
D [auth H]C1-set_1e1i9rH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
F [auth K]V-set_8e1i9rK1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
F [auth K]C1-set_1e1i9rK2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
H [auth X]V-set_8e1i9rX1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
H [auth X]C1-set_1e1i9rX2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
E [auth L]C1-set_4e1i9rL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
E [auth L]V-sete1i9rL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
G [auth M]C1-set_4e1i9rM2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
G [auth M]V-sete1i9rM1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
I [auth Y]C1-set_4e1i9rY2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
I [auth Y]V-sete1i9rY1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
ATNFe1i9rA1 A: beta sandwichesX: jelly-rollH: TNF-like (From Topology)T: TNF-likeF: TNFECOD (1.6)
BTNFe1i9rB1 A: beta sandwichesX: jelly-rollH: TNF-like (From Topology)T: TNF-likeF: TNFECOD (1.6)
CTNFe1i9rC1 A: beta sandwichesX: jelly-rollH: TNF-like (From Topology)T: TNF-likeF: TNFECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
D [auth H]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
F [auth K]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
H [auth X]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
E [auth L]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
G [auth M]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
I [auth Y]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
A2.60.120.40 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)
B2.60.120.40 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)
C2.60.120.40 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
D [auth H],
F [auth K],
H [auth X]
Humanized 5C8 neutralizing mAb, anti-CD40 ligand VH-CH1 Humanized (humanized) IGHV1-46*01, IGHV1-46*03, IGHJ5*01, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202447-0)
E [auth L],
G [auth M],
I [auth Y]
Humanized 5C8 neutralizing mAb, anti-CD40 ligand L-KAPPA Humanized (humanized) IGKV3-11*01, IGKJ4*01, IGKJ4*02, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202447-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
D [auth H],
F [auth K],
H [auth X]
Heavy ChainIGHV1 -cd40 ligandSAbDab (2024-11-29)
E [auth L],
G [auth M],
I [auth Y]
Light ChainIGKV3D Kappacd40 ligandSAbDab (2024-11-29)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

ChainNameTargetProvenance Source
D [auth H],
F [auth K],
H [auth X]
Tegoprubart CD40LG/CD154Therapeutic SAbDab (2024-11-29)
E [auth L],
G [auth M],
I [auth Y]
Tegoprubart CD40LG/CD154Therapeutic SAbDab (2024-11-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C
PF00229TNF(Tumour Necrosis Factor) family (TNF)TNF(Tumour Necrosis Factor) family- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
D [auth H],
F [auth K],
H [auth X]
IMMUNOGLOBULIN H---
E [auth L],
G [auth M],
I [auth Y]
IMMUNOGLOBULIN L---
A, B, C
CD40 LIGAND