Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1i9ra_ All beta proteins TNF-like TNF-like TNF-like Extracellular domain of CD40 ligand human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd1i9rc_ All beta proteins TNF-like TNF-like TNF-like Extracellular domain of CD40 ligand human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd1i9rb_ All beta proteins TNF-like TNF-like TNF-like Extracellular domain of CD40 ligand human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
E [auth L]d1i9rl1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
E [auth L]d1i9rl2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
G [auth M]d1i9rm1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
G [auth M]d1i9rm2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
I [auth Y]d1i9ry1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
I [auth Y]d1i9ry2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth H]d1i9rh1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth H]d1i9rh2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth K]d1i9rk1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth K]d1i9rk2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
H [auth X]d1i9rx1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
H [auth X]d1i9rx2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyTNF-like 8041217 3000061 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyTNF-like 8041217 3000061 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyTNF-like 8041217 3000061 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATNFe1i9rA1 A: beta sandwichesX: jelly-rollH: TNF-like (From Topology)T: TNF-likeF: TNFECOD (1.6)
CTNFe1i9rC1 A: beta sandwichesX: jelly-rollH: TNF-like (From Topology)T: TNF-likeF: TNFECOD (1.6)
BTNFe1i9rB1 A: beta sandwichesX: jelly-rollH: TNF-like (From Topology)T: TNF-likeF: TNFECOD (1.6)
E [auth L]C1-set_4e1i9rL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
E [auth L]V-sete1i9rL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
G [auth M]C1-set_4e1i9rM2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
G [auth M]V-sete1i9rM1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
I [auth Y]C1-set_4e1i9rY2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
I [auth Y]V-sete1i9rY1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
D [auth H]V-set_8e1i9rH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
D [auth H]C1-set_1e1i9rH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
F [auth K]V-set_8e1i9rK1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
F [auth K]C1-set_1e1i9rK2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
H [auth X]V-set_8e1i9rX1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
H [auth X]C1-set_1e1i9rX2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.60.120.40 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)
C2.60.120.40 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)
B2.60.120.40 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)
E [auth L]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
G [auth M]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
I [auth Y]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
D [auth H]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
F [auth K]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
H [auth X]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
E [auth L],
G [auth M],
I [auth Y]
Humanized 5C8 neutralizing mAb, anti-CD40 ligand L-KAPPA Humanized (humanized) IGKV3-11*01, IGKJ4*01, IGKJ4*02, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202447-0)
D [auth H],
F [auth K],
H [auth X]
Humanized 5C8 neutralizing mAb, anti-CD40 ligand VH-CH1 Humanized (humanized) IGHV1-46*01, IGHV1-46*03, IGHJ5*01, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202447-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
E [auth L],
G [auth M],
I [auth Y]
Light ChainIGKV3D Kappacd40 ligandSAbDab (2024-11-29)
D [auth H],
F [auth K],
H [auth X]
Heavy ChainIGHV1 -cd40 ligandSAbDab (2024-11-29)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

ChainNameTargetProvenance Source
E [auth L],
G [auth M],
I [auth Y]
Tegoprubart CD40LG/CD154Therapeutic SAbDab (2024-11-29)
D [auth H],
F [auth K],
H [auth X]
Tegoprubart CD40LG/CD154Therapeutic SAbDab (2024-11-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C
PF00229TNF(Tumour Necrosis Factor) family (TNF)TNF(Tumour Necrosis Factor) family- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C
CD40 LIGAND
E [auth L],
G [auth M],
I [auth Y]
IMMUNOGLOBULIN L---
D [auth H],
F [auth K],
H [auth X]
IMMUNOGLOBULIN H---