Annotations: 1H5S

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d1h5sd_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	glucose-1-phosphate thymidylyltransferase	RmlA (RfbA)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1h5sa_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	glucose-1-phosphate thymidylyltransferase	RmlA (RfbA)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1h5sb_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	glucose-1-phosphate thymidylyltransferase	RmlA (RfbA)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1h5sc_	Alpha and beta proteins (a/b)	Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	glucose-1-phosphate thymidylyltransferase	RmlA (RfbA)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8036276	3000077	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8036276	3000077	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8036276	3000077	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8036276	3000077	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	NTP_transferase	e1h5sD1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: NTP_transferase	ECOD (1.6)
A	NTP_transferase	e1h5sA1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: NTP_transferase	ECOD (1.6)
B	NTP_transferase	e1h5sB1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: NTP_transferase	ECOD (1.6)
C	NTP_transferase	e1h5sC1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: NTP_transferase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
A	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
B	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
C	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D	PF00483	Nucleotidyl transferase (NTP_transferase)	Nucleotidyl transferase	-	Family
A	PF00483	Nucleotidyl transferase (NTP_transferase)	Nucleotidyl transferase	-	Family
B	PF00483	Nucleotidyl transferase (NTP_transferase)	Nucleotidyl transferase	-	Family
C	PF00483	Nucleotidyl transferase (NTP_transferase)	Nucleotidyl transferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
D	Glucose-1-phosphate thymidylyltransferase 1	transferase activity nucleotidyltransferase activity catalytic activity glucose-1-phosphate thymidylyltransferase activity transferase activity, transferring phosphorus-containing groups cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process nucleotide-sugar metabolic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process nucleotide-sugar metabolic process carbohydrate derivative metabolic process primary metabolic process dTDP-rhamnose biosynthetic process nucleobase-containing compound biosynthetic process dTDP-rhamnose metabolic process nucleobase-containing compound metabolic process biosynthetic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process metabolic process small molecule metabolic process phosphorus metabolic process nucleotide-sugar biosynthetic process lipopolysaccharide biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process liposaccharide metabolic process lipid biosynthetic process macromolecule biosynthetic process O antigen biosynthetic process lipopolysaccharide metabolic process O antigen metabolic process polysaccharide metabolic process macromolecule metabolic process lipid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol
A	Glucose-1-phosphate thymidylyltransferase 1	transferase activity nucleotidyltransferase activity catalytic activity glucose-1-phosphate thymidylyltransferase activity transferase activity, transferring phosphorus-containing groups cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process nucleotide-sugar metabolic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process nucleotide-sugar metabolic process carbohydrate derivative metabolic process primary metabolic process dTDP-rhamnose biosynthetic process nucleobase-containing compound biosynthetic process dTDP-rhamnose metabolic process nucleobase-containing compound metabolic process biosynthetic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process metabolic process small molecule metabolic process phosphorus metabolic process nucleotide-sugar biosynthetic process lipopolysaccharide biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process liposaccharide metabolic process lipid biosynthetic process macromolecule biosynthetic process O antigen biosynthetic process lipopolysaccharide metabolic process O antigen metabolic process polysaccharide metabolic process macromolecule metabolic process lipid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol
B	Glucose-1-phosphate thymidylyltransferase 1	transferase activity nucleotidyltransferase activity catalytic activity glucose-1-phosphate thymidylyltransferase activity transferase activity, transferring phosphorus-containing groups cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process nucleotide-sugar metabolic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process nucleotide-sugar metabolic process carbohydrate derivative metabolic process primary metabolic process dTDP-rhamnose biosynthetic process nucleobase-containing compound biosynthetic process dTDP-rhamnose metabolic process nucleobase-containing compound metabolic process biosynthetic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process metabolic process small molecule metabolic process phosphorus metabolic process nucleotide-sugar biosynthetic process lipopolysaccharide biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process liposaccharide metabolic process lipid biosynthetic process macromolecule biosynthetic process O antigen biosynthetic process lipopolysaccharide metabolic process O antigen metabolic process polysaccharide metabolic process macromolecule metabolic process lipid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol
C	Glucose-1-phosphate thymidylyltransferase 1	transferase activity nucleotidyltransferase activity catalytic activity glucose-1-phosphate thymidylyltransferase activity transferase activity, transferring phosphorus-containing groups cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process nucleotide-sugar metabolic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process nucleotide-sugar metabolic process carbohydrate derivative metabolic process primary metabolic process dTDP-rhamnose biosynthetic process nucleobase-containing compound biosynthetic process dTDP-rhamnose metabolic process nucleobase-containing compound metabolic process biosynthetic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process metabolic process small molecule metabolic process phosphorus metabolic process nucleotide-sugar biosynthetic process lipopolysaccharide biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process liposaccharide metabolic process lipid biosynthetic process macromolecule biosynthetic process O antigen biosynthetic process lipopolysaccharide metabolic process O antigen metabolic process polysaccharide metabolic process macromolecule metabolic process lipid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D	IPR005835	Nucleotidyl transferase domain	Domain
D	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
D	IPR005907	Glucose-1-phosphate thymidylyltransferase, short form	Family
A	IPR005835	Nucleotidyl transferase domain	Domain
A	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A	IPR005907	Glucose-1-phosphate thymidylyltransferase, short form	Family
B	IPR005835	Nucleotidyl transferase domain	Domain
B	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
B	IPR005907	Glucose-1-phosphate thymidylyltransferase, short form	Family
C	IPR005835	Nucleotidyl transferase domain	Domain
C	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
C	IPR005907	Glucose-1-phosphate thymidylyltransferase, short form	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.