Annotations: 1E4V

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1e4va1	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Nucleotide and nucleoside kinases	Adenylate kinase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1e4va2	Small proteins	Rubredoxin-like	Microbial and mitochondrial ADK, insert 'zinc finger' domain	Microbial and mitochondrial ADK, insert 'zinc finger' domain	Microbial and mitochondrial ADK, insert 'zinc finger' domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1e4vb1	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Nucleotide and nucleoside kinases	Adenylate kinase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1e4vb2	Small proteins	Rubredoxin-like	Microbial and mitochondrial ADK, insert 'zinc finger' domain	Microbial and mitochondrial ADK, insert 'zinc finger' domain	Microbial and mitochondrial ADK, insert 'zinc finger' domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Adenylate kinase-like	8058333	4004025	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	P-loop nucleotide/nucleoside kinase-like	8058334	3002021	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8058334	3002021	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Cytidylate_kin_2,Thymidylate_kin	e1e4vA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Cytidylate_kin_2,Thymidylate_kin	ECOD (1.6)
A	ADK_lid	e1e4vA1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: ADK_lid	ECOD (1.6)
B	Cytidylate_kin_2,Thymidylate_kin	e1e4vB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Cytidylate_kin_2,Thymidylate_kin	ECOD (1.6)
B	ADK_lid	e1e4vB1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: ADK_lid	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00406	Adenylate kinase (ADK)	Adenylate kinase		Domain
A, B	PF05191	Adenylate kinase, active site lid (ADK_lid)	Adenylate kinase, active site lid	Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organisms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are resp ...	Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organisms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Adenylate kinase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding nucleobase-containing compound kinase activity kinase activity transferase activity catalytic activity phosphotransferase activity, phosphate group as acceptor nucleoside diphosphate kinase activity transferase activity, transferring phosphorus-containing groups nucleoside monophosphate kinase activity adenylate kinase activity AMP binding	ribose phosphate metabolic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside diphosphate biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process nucleoside diphosphate biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process phosphate-containing compound metabolic process ribonucleoside diphosphate metabolic process ribose phosphate metabolic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside diphosphate biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process nucleoside diphosphate biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process phosphate-containing compound metabolic process ribonucleoside diphosphate metabolic process ADP biosynthetic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside diphosphate metabolic process primary metabolic process purine nucleoside diphosphate biosynthetic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process ADP metabolic process nucleoside diphosphate metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process purine ribonucleoside diphosphate metabolic process metabolic process cellular process purine ribonucleotide metabolic process purine nucleotide biosynthetic process ribonucleoside diphosphate biosynthetic process nucleoside monophosphate metabolic process purine ribonucleoside monophosphate biosynthetic process AMP metabolic process nucleotide salvage metabolic compound salvage purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process ribonucleoside monophosphate metabolic process purine nucleoside monophosphate metabolic process purine nucleotide salvage AMP salvage purine-containing compound salvage nucleoside monophosphate biosynthetic process purine ribonucleotide salvage AMP biosynthetic process ribonucleoside monophosphate biosynthetic process purine nucleobase metabolic process nucleobase metabolic process adenine metabolic process purine ribonucleotide interconversion purine nucleotide interconversion nucleobase-containing small molecule interconversion	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006259	Adenylate kinase subfamily	Family
A, B	IPR007862	Adenylate kinase, active site lid domain	Domain
A, B	IPR000850	Adenylate kinase/UMP-CMP kinase	Family
A, B	IPR033690	Adenylate kinase, conserved site	Conserved Site
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.