Annotations: 1CZV

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1czvb_	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)	C2 domain of factor V	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1czva_	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)	C2 domain of factor V	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	galactose-binding domain-like	8041135	3000087	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	galactose-binding domain-like	8041135	3000087	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	F5_F8_type_C	e1czvB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: F5_F8_type_C	ECOD (1.6)
A	F5_F8_type_C	e1czvA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: F5_F8_type_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00754	F5/8 type C domain (F5_F8_type_C)	F5/8 type C domain	This domain is also known as the discoidin (DS) domain family [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PROTEIN (COAGULATION FACTOR V)	cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding response to nutrient levels response to ketone response to chemical multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding response to nutrient levels response to ketone response to chemical response to nutrient response to oxygen-containing compound response to vitamin K response to vitamin system process circulatory system process blood circulation	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region intracellular vesicle cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule vesicle bounding membrane of organelle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment organelle membrane extracellular vesicle extracellular organelle extracellular membrane-bounded organelle vesicle lumen cytoplasmic vesicle lumen secretory granule lumen platelet alpha granule lumen cell periphery plasma membrane COPII-coated ER to Golgi transport vesicle coated vesicle extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR033138	Multicopper oxidases, conserved site	Conserved Site
A, B	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A, B	IPR011707	Multicopper oxidase-like, N-terminal	Domain
A, B	IPR024715	Coagulation factor 5/8-like	Family
A, B	IPR000421	Coagulation factor 5/8, C-terminal domain	Domain
A, B	IPR008972	Cupredoxin	Homologous Superfamily
A, B	IPR050633	Neuropilin/Multicopper Oxidase/Coagulation Factor	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P12259	congenital factor V deficiency retinal vein occlusion thrombophilia due to activated protein C resistance pregnancy loss, recurrent, susceptibility to, 1 sagittal sinus thrombosis hepatic vein thrombosis Budd-Chiari syndrome Venous Thrombosis myocardial infarction cirrhosis of liver thrombophilia brain ischemia classic familial adenomatous polyposis malignant colon neoplasm thrombotic disease congenital factor V deficiency retinal vein occlusion thrombophilia due to activated protein C resistance pregnancy loss, recurrent, susceptibility to, 1 sagittal sinus thrombosis hepatic vein thrombosis Budd-Chiari syndrome Venous Thrombosis myocardial infarction cirrhosis of liver thrombophilia brain ischemia classic familial adenomatous polyposis malignant colon neoplasm thrombotic disease cerebral infarction venous thromboembolism pancreatic intraductal papillary-mucinous carcinoma peripheral arterial disease East Texas bleeding disorder factor V deficiency acne astrocytic tumor blood coagulation disease MALT lymphoma tuberculosis cerebrovascular disorder ovarian cancer colonic neoplasm pancreatic intraductal papillary-mucinous neoplasm cystic fibrosis Pick disease esophageal adenocarcinoma rheumatoid arthritis inflammatory bowel disease lung cancer Barrett esophagus malignant ependymoma ulcerative colitis oligodendroglioma pancreatic ductal adenocarcinoma colorectal cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer exocrine pancreatic carcinoma genetic intestinal polyposis sinusitis intellectual disability lung carcinoma benign colon neoplasm malignant pancreatic neoplasm osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.