Annotations: 1BY6

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1by6a_	Peptides	Fragments of apolipoproteins	Fragments of apolipoproteins	Fragments of apolipoproteins	Fragments of apolipoproteins	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05355	Apolipoprotein C-II (Apo-CII)	Apolipoprotein C-II	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	APOLIPOPROTEIN C-II	phospholipase binding protein binding binding enzyme binding enzyme regulator activity molecular function activator activity triacylglycerol lipase activity carboxylic ester hydrolase activity hydrolase activity lipoprotein lipase activity lipase activity enzyme activator activity hydrolase activity, acting on ester bonds lipoprotein lipase activator activity phospholipase binding protein binding binding enzyme binding enzyme regulator activity molecular function activator activity triacylglycerol lipase activity carboxylic ester hydrolase activity hydrolase activity lipoprotein lipase activity lipase activity enzyme activator activity hydrolase activity, acting on ester bonds lipoprotein lipase activator activity molecular function regulator activity lipase activator activity catalytic activity lipid binding phospholipase activity phospholipase activator activity molecular function inhibitor activity enzyme inhibitor activity lipase inhibitor activity	plasma lipoprotein particle organization multicellular organismal process regulation of biological process protein-containing complex organization protein-containing complex remodeling protein-lipid complex organization biological regulation plasma lipoprotein particle remodeling regulation of plasma lipoprotein particle levels cellular component organization chylomicron remodeling triglyceride-rich lipoprotein particle remodeling protein-lipid complex remodeling cellular process plasma lipoprotein particle organization multicellular organismal process regulation of biological process protein-containing complex organization protein-containing complex remodeling protein-lipid complex organization biological regulation plasma lipoprotein particle remodeling regulation of plasma lipoprotein particle levels cellular component organization chylomicron remodeling triglyceride-rich lipoprotein particle remodeling protein-lipid complex remodeling cellular process cellular component organization or biogenesis localization transport macromolecule localization reverse cholesterol transport lipid localization cholesterol transport lipid transport sterol transport organic hydroxy compound transport establishment of localization phospholipid transport organophosphate ester transport phospholipid efflux chemical homeostasis homeostatic process triglyceride homeostasis acylglycerol homeostasis lipid homeostasis regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization positive regulation of biological process very-low-density lipoprotein particle remodeling regulation of multicellular organismal process positive regulation of cellular process positive regulation of very-low-density lipoprotein particle remodeling regulation of very-low-density lipoprotein particle remodeling positive regulation of multicellular organismal process oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process regulation of primary metabolic process positive regulation of fatty acid biosynthetic process positive regulation of metabolic process regulation of small molecule metabolic process positive regulation of biosynthetic process positive regulation of lipid metabolic process small molecule metabolic process positive regulation of fatty acid metabolic process regulation of biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process regulation of ketone metabolic process biosynthetic process positive regulation of lipid biosynthetic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process metabolic process monocarboxylic acid metabolic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process regulation of metabolic process lipid metabolic process sterol homeostasis cholesterol homeostasis neutral lipid metabolic process catabolic process regulation of triglyceride metabolic process positive regulation of triglyceride metabolic process glycerolipid catabolic process triglyceride catabolic process positive regulation of lipid catabolic process triglyceride metabolic process lipid catabolic process neutral lipid catabolic process acylglycerol catabolic process regulation of catabolic process regulation of lipid catabolic process positive regulation of catabolic process positive regulation of triglyceride catabolic process glycerolipid metabolic process acylglycerol metabolic process regulation of triglyceride catabolic process regulation of phospholipase activity regulation of molecular function positive regulation of molecular function positive regulation of hydrolase activity positive regulation of phospholipase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity positive regulation of lipase activity regulation of localization import into cell negative regulation of biological process negative regulation of transport negative regulation of endocytosis vesicle-mediated transport negative regulation of cellular process regulation of endocytosis negative regulation of cellular component organization negative regulation of receptor-mediated endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport endocytosis receptor-mediated endocytosis positive regulation of lipoprotein lipase activity positive regulation of triglyceride lipase activity phospholipid catabolic process organophosphate catabolic process positive regulation of phosphate metabolic process positive regulation of phospholipid catabolic process phospholipid metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process regulation of phospholipid catabolic process positive regulation of phosphorus metabolic process regulation of phospholipid metabolic process positive regulation of phospholipid metabolic process organophosphate metabolic process regulation of phosphorus metabolic process very-low-density lipoprotein particle clearance plasma lipoprotein particle clearance negative regulation of very-low-density lipoprotein particle clearance negative regulation of lipoprotein particle clearance regulation of lipoprotein particle clearance regulation of very-low-density lipoprotein particle clearance negative regulation of multicellular organismal process high-density lipoprotein particle clearance negative regulation of sterol transport regulation of lipid transport negative regulation of lipid localization regulation of cholesterol transport regulation of sterol transport negative regulation of lipid transport negative regulation of cholesterol transport regulation of lipid localization negative regulation of metabolic process negative regulation of lipid metabolic process cholesterol efflux chylomicron remnant clearance triglyceride-rich lipoprotein particle clearance lipoprotein metabolic process protein catabolic process protein metabolic process macromolecule metabolic process lipoprotein catabolic process macromolecule catabolic process	spherical high-density lipoprotein particle protein-containing complex cellular anatomical structure extracellular region plasma lipoprotein particle high-density lipoprotein particle extracellular space lipoprotein particle protein-lipid complex membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle spherical high-density lipoprotein particle protein-containing complex cellular anatomical structure extracellular region plasma lipoprotein particle high-density lipoprotein particle extracellular space lipoprotein particle protein-lipid complex membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle chylomicron low-density lipoprotein particle intermediate-density lipoprotein particle triglyceride-rich plasma lipoprotein particle very-low-density lipoprotein particle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR023121	ApoC-II domain superfamily	Homologous Superfamily
A	IPR008019	Apolipoprotein C-II	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P02655	familial lipoprotein lipase deficiency Liver Neoplasms, Experimental familial apolipoprotein C-II deficiency familial hyperlipidemia periodic fever syndrome abdominal aortic aneurysm inborn errors of metabolism myocardial infarction vascular dementia age-related macular degeneration cerebrovascular disorder heart disease inherited lipid metabolism disorder metabolic syndrome X non-alcoholic fatty liver disease familial lipoprotein lipase deficiency Liver Neoplasms, Experimental familial apolipoprotein C-II deficiency familial hyperlipidemia periodic fever syndrome abdominal aortic aneurysm inborn errors of metabolism myocardial infarction vascular dementia age-related macular degeneration cerebrovascular disorder heart disease inherited lipid metabolism disorder metabolic syndrome X non-alcoholic fatty liver disease wet macular degeneration Alzheimer disease Lewy body dementia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.