Annotations: 1ARK

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1arka_	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	SH3 domain from nebulin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SH3-domain	8029192	4000369	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SH3-domain	8041571	3000153	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_1	e1arkA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	NEBULIN	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding structural molecule activity structural constituent of muscle	multicellular organismal process cellular developmental process cardiac muscle cell development cellular component assembly involved in morphogenesis cell development membraneless organelle assembly muscle cell differentiation striated muscle tissue development cellular component organization cellular component biogenesis muscle structure development multicellular organism development striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly multicellular organismal process cellular developmental process cardiac muscle cell development cellular component assembly involved in morphogenesis cell development membraneless organelle assembly muscle cell differentiation striated muscle tissue development cellular component organization cellular component biogenesis muscle structure development multicellular organism development striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation actin filament-based process anatomical structure development cellular component organization or biogenesis cardiac cell development muscle tissue development system development developmental process heart development actin cytoskeleton organization actomyosin structure organization organelle assembly cardiac muscle tissue development actin filament organization animal organ development cardiac muscle cell differentiation tissue development cardiocyte differentiation circulatory system development anatomical structure morphogenesis organelle organization myofibril assembly cardiac myofibril assembly cardiac muscle thin filament assembly anatomical structure formation involved in morphogenesis cellular process striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization somatic muscle development muscle organ development regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process regulation of actin filament-based process regulation of cellular component size biological regulation regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization regulation of biological quality regulation of anatomical structure size	intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoskeleton actin cytoskeleton cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035629	Nebulin, SH3 domain	Domain
A	IPR055297	Nebulin/Nebulette	Family
A	IPR001452	SH3 domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR000900	Nebulin repeat	Repeat
A	IPR013998	Nebulin-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P20929	nemaline myopathy 2 nemaline myopathy myopathy adrenal cortex carcinoma congestive heart failure intellectual disability lung carcinoma muscular disease psoriasis arthrogryposis distal myopathy lethal multiple pterygium syndrome malignant ependymoma Nemaline Myopathy, Childhood Onset type 2 diabetes mellitus nemaline myopathy 2 nemaline myopathy myopathy adrenal cortex carcinoma congestive heart failure intellectual disability lung carcinoma muscular disease psoriasis arthrogryposis distal myopathy lethal multiple pterygium syndrome malignant ependymoma Nemaline Myopathy, Childhood Onset type 2 diabetes mellitus lung cancer muscle tissue disease non-immune hydrops fetalis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.