Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.

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RCSB PDB Mol* Viewer 2.11.1 [12/17/2024, 1:59:56 PM]
Sequence of
58   ​M​​A​​L​​G​​E​​L​​K​​D​​D​​D​68   ​F​​E​​K​​I​​S​​E​​L​​G​​A​​G​78   ​N​​G​​G​​V​​V​​F​​K​​V​​S​​H​88   ​K​​P​​S​​G​​L​​V​​M​​A​​R​​K​98   ​L​​I​​H​​L​​E​​I​​K​​P​​A​​I​108  ​R​​N​​Q​​I​​I​​R​​E​​L​​Q​​V​118  ​L​​H​​E​​C​​N​​S​​P​​Y​​I​​V​128  ​G​​F​​Y​​G​​A​​F​​Y​​S​​D​​G​138  ​E​​I​​S​​I​​C​​M​​E​​H​​M​​D​148  ​G​​G​​S​​L​​D​​Q​​V​​L​​K​​K​158  ​A​​G​​R​​I​​P​​E​​Q​​I​​L​​G​168  ​K​​V​​S​​I​​A​​V​​I​​K​​G​​L​178  ​T​​Y​​L​​R​​E​​K​​H​​K​​I​​M​188  ​H​​R​​D​​V​​K​​P​​S​​N​​I​​L​198  ​V​​N​​S​​R​​G​​E​​I​​K​​L​​C​208  ​D​​F​​G​​V​​S​​G​​Q​​L​​I​​D​218  ​E​​M​​A​​N​​E​​F​​V​​G​​T​​R​228  ​S​​Y​​M​​S​​P​​E​​R​​L​​Q​​G​238  ​T​​H​​Y​​S​​V​​Q​​S​​D​​I​​W​248  ​S​​M​​G​​L​​S​​L​​V​​E​​M​​A​258  ​V​​G​​R​​Y​​P​​R​​P​​P​​M​​A​310  ​I​​F​​E​​L​​L​​D​​Y​​I​​V​​N​320  ​E​​P​​P​​P​​K​​L​​P​​S​​A​​V​330  ​F​​S​​L​​E​​F​​Q​​D​​F​​V​​N​340  ​K​​C​​L​​I​​K​​N​​P​​A​​E​​R​350  ​A​​D​​L​​K​​Q​​L​​M​​V​​H​​A​360  ​F​​I​​K​​R​​S​​D​​A​​E​​E​​V​370  ​D​​F​​A​​G​​W​​L​​C​​S​​T​​I​380  ​G​​L​​N​​Q​​P​​S​​T​​P​​T​​H​     ​A​​A​​G​​E​​G​​H​​H​​H​​H​​H​     ​H​
Type
Asm Id
Dynamic Bonds

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