Download MendeleyStructural analyses of the ubiquitin-conjugating enzyme UBE2S in different crystal forms
Liess, A.K.L., Feiler, C.G., Lorenz, S.To be published.
7AHF
Dimeric structure of the catalytic domain of the human ubiquitin-conjugating enzyme UBE2S L114E varaiant
- PDB DOI: https://doi.org/10.2210/pdb7AHF/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2020-09-24 Released: 2021-10-06
- Funding Organization(s): German Research Foundation (DFG)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.15 Å
- R-Value Free: 0.239
- R-Value Work: 0.191
- R-Value Observed: 0.194
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Ubiquitin-conjugating enzyme E2 S | A [auth B], B [auth A] | 156 | Homo sapiens | Mutation(s): 1 Gene Names: UBE2S, E2EPF, OK/SW-cl.73 EC: 2.3.2.23 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q16763 (Homo sapiens) Explore Q16763 Go to UniProtKB: Q16763 | |||||
PHAROS: Q16763 GTEx: ENSG00000108106 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q16763 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GOL Query on GOL | D [auth B] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| EDO Query on EDO | C [auth B], E [auth A], F [auth A], G [auth A] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.15 Å
- R-Value Free: 0.239
- R-Value Work: 0.191
- R-Value Observed: 0.194
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 45.317 | α = 90 |
| b = 48.411 | β = 107.07 |
| c = 70.127 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| Aimless | data scaling |
| PHASER | phasing |
| PDB_EXTRACT | data extraction |
Entry History & Funding Information
Deposition Data
- Released Date: 2021-10-06 Deposition Author(s): Liess, A.K.L., Feiler, C.G., Lorenz, S.
| Funding Organization | Location | Grant Number |
|---|---|---|
| German Research Foundation (DFG) | Germany | Emmy Noether LO 2003/1-1 |
Revision History (Full details and data files)
- Version 1.0: 2021-10-06
Type: Initial release - Version 1.1: 2024-01-31
Changes: Data collection, Refinement description - Version 1.2: 2024-11-13
Changes: Structure summary
