1ME3

Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain

(2003) Bioorg Med Chem 11: 21-29

• PubMed: 12467703 Search on PubMed
• DOI: https://doi.org/10.1016/s0968-0896(02)00427-3
• Primary Citation of Related Structures:  
  1ME3, 1ME4


• PubMed Abstract: 
  

  The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.

   View More

---

Organizational Affiliation: 

Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley 94720, USA.