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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Keywords HAS EXACT PHRASE "SIGNALING PROTEIN"

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Search Summary

This query matches 6,851 Structures.

Refinements

Structure Determination Methodology

experimental (6,851)

Scientific Name of Source Organism

	Homo sapiens (4,257)
	Mus musculus (663)
	Rattus norvegicus (307)
	synthetic construct (222)
	Bos taurus (221)
	Escherichia coli (173)
	Arabidopsis thaliana (92)
	Lama glama (91)
	Escherichia coli K-12 (88)
	Saccharomyces cerevisiae (83)

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Taxonomy

	Eukaryota (5,584)
	Bacteria (1,368)
	other sequences (226)
	Eukaryota (eukaryotes) (106)
	Archaea (83)
	Duplodnaviria (70)
	Riboviria (27)
	unclassified sequences (11)
	Varidnaviria (4)
	Riboviria (RNA viruses and viroids) (1)

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Experimental Method

	X-RAY DIFFRACTION (5,304)
	ELECTRON MICROSCOPY (855)
	SOLUTION NMR (681)
	SOLID-STATE NMR (7)
	NEUTRON DIFFRACTION (5)
	POWDER DIFFRACTION (1)
	SOLUTION SCATTERING (1)

Polymer Entity Type

	Protein (6,851)
	RNA (29)
	DNA (11)

Refinement Resolution (Å)

	0.5 - 1.0 (23)
	1.0 - 1.5 (527)
	1.5 - 2.0 (1,614)
	2.0 - 2.5 (1,505)
	2.5 - 3.0 (1,203)
	3.0 - 3.5 (769)
	3.5 - 4.0 (284)
	4.0 - 4.5 (103)
	> 4.5 (134)

Release Date

	1995 - 1999 (42)
	2000 - 2004 (521)
	2005 - 2009 (1,036)
	2010 - 2014 (1,158)
	2015 - 2019 (1,725)
	2020 - 2024 (2,201)
	2025 - 2029 (168)

Enzyme Classification Name

	Transferases (1,359)
	Hydrolases (1,315)
	Ligases (57)
	Lyases (48)
	Isomerases (43)
	Oxidoreductases (25)

Membrane Protein Annotation

	PDBTM (668)
	mpstruc (397)
	MemProtMD (427)
	OPM (396)

Symmetry Type

	Asymmetric (5,169)
	Cyclic (1,844)
	Dihedral (119)
	Helical (30)
	Tetrahedral (4)
	Octahedral (3)
	Icosahedral (2)

SCOP Classification

	Alpha and beta proteins (a+b) (1,012)
	All beta proteins (713)
	Artifacts (841)
	All alpha proteins (733)
	Alpha and beta proteins (a/b) (764)
	Small proteins (105)
	Membrane and cell surface proteins and peptides (50)
	Multi-domain proteins (alpha and beta) (17)
	Peptides (29)
	Coiled coil proteins (12)

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1 to 25 of 6,851 Structures

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1GCQ \| pdb_00001gcq	Download File View File

CRYSTAL STRUCTURE OF VAV AND GRB2 SH3 DOMAINS

Nishida, M., Nagata, K., Hachimori, Y., Ogura, K., Inagaki, F.

(2001) EMBO J 20: 2995-3007

Released	2001-08-08
Method	X-RAY DIFFRACTION 1.68 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 (protein) VAV PROTO-ONCOGENE (protein)
Unique Ligands	MRD

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1UJ0 \| pdb_00001uj0	Download File View File

Crystal Structure of STAM2 SH3 domain in complex with a UBPY-derived peptide

Kaneko, T., Kumasaka, T., Ganbe, T., Sato, T., Miyazawa, K., Kitamura, N., Tanaka, N.

(2003) J Biological Chem 278: 48162-48168

Released	2003-12-23
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Mus musculus
Macromolecule	deubiquitinating enzyme UBPY (protein) signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 (protein)
Unique Ligands	PO4

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3C59 \| pdb_00003c59	Download File View File

Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

Runge, S.

(2008) J Biological Chem 283: 11340-11347

Released	2008-02-19
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Heloderma suspectum Homo sapiens
Macromolecule	Exendin-4 (protein) Glucagon-like peptide 1 receptor (protein)
Unique Ligands	10M

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3C5T \| pdb_00003c5t	Download File View File

Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

Runge, S.

(2008) J Biological Chem 283: 11340-11347

Released	2008-02-19
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Heloderma suspectum Homo sapiens
Macromolecule	Exendin-4 (protein) Glucagon-like peptide 1 receptor (protein)
Unique Ligands	10M

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3F6Q \| pdb_00003f6q	Download File View File

Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain

Chiswell, B.P., Calderwood, D.A., Boggon, T.J.

(2008) Proc Natl Acad Sci U S A 105: 20677-20682

Released	2008-12-02
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Integrin-linked protein kinase (protein) LIM and senescent cell antigen-like-containing domain protein 1 (protein)
Unique Ligands	IOD, PO4, ZN

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3GNI \| pdb_00003gni	Download File View File

Structure of STRAD and MO25

Zeqiraj, E., Goldie, S., Alessi, D.R., van Aalten, D.M.F.

(2009) PLoS Biol 7: e1000126-e1000126

Released	2009-06-16
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Protein Mo25 (protein) STRAD alpha (protein)
Unique Ligands	ATP, CIT

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3IOL \| pdb_00003iol	Download File View File

Crystal structure of Glucagon-Like Peptide-1 in complex with the extracellular domain of the Glucagon-Like Peptide-1 Receptor

Reedtz-Runge, S.

(2010) J Biological Chem 285: 723-730

Released	2009-10-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Glucagon (protein) Glucagon-like peptide 1 receptor (protein)
Unique Ligands	10M

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3IXE \| pdb_00003ixe	Download File View File

Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase

Chiswell, B.P., Stiegler, A.L., Boggon, T.J., Calderwood, D.A.

(2010) J Struct Biol 170: 157-163

Released	2009-12-15
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Integrin-linked protein kinase (protein) LIM and senescent cell antigen-like-containing domain protein 2 (protein)
Unique Ligands	ZN

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3LB6 \| pdb_00003lb6	Download File View File

The structure of IL-13 in complex with IL-13Ralpha2

Lupardus, P.J., Garcia, K.C., Birnbaum, M.E.

(2010) Structure 18: 332-342

Released	2010-03-16
Method	X-RAY DIFFRACTION 3.05 Å
Organisms	Homo sapiens
Macromolecule	Interleukin-13 (protein) Interleukin-13 receptor subunit alpha-2 (protein)
Unique Ligands	CA, NAG

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3LNY \| pdb_00003lny	Download File View File

Second PDZ domain from human PTP1E in complex with RA-GEF2 peptide

Zhang, J., Chang, A., Ke, H., Phillips Jr., G.N., Lee, A.L., Center for Eukaryotic Structural Genomics (CESG)

(2010) Biochemistry 49: 9280-9291

Released	2010-03-23
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Homo sapiens
Macromolecule	Rap guanine nucleotide exchange factor 6 (protein) Tyrosine-protein phosphatase non-receptor type 13 (protein)
Unique Ligands	SCN, SO4

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3M4W \| pdb_00003m4w	Download File View File

Structural basis for the negative regulation of bacterial stress response by RseB

Kim, D.Y., Kwon, E., Choi, J.K., Hwang, H.-Y., Kim, K.K.

(2010) Protein Sci 19: 1258-1263

Released	2010-05-05
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Escherichia coli K-12
Macromolecule	Sigma-E factor negative regulatory protein (protein) Sigma-E factor regulatory protein rseB (protein)
Unique Ligands	ZN

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4FAO \| pdb_00004fao	Download File View File

Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex

Townson, S.A., Martinez-Hackert, E., Greppi, C., Lowden, P., Sako, D., Liu, J., Ucran, J.A., Liharska, K., Underwood, K.W., Seehra, J., Kumar, R., Grinberg, A.V.

(2012) J Biological Chem 287: 27313-27325

Released	2012-06-20
Method	X-RAY DIFFRACTION 3.357 Å
Organisms	Homo sapiens
Macromolecule	Activin receptor type-2B (protein) Growth/differentiation factor 2 (protein) Serine/threonine-protein kinase receptor R3 (protein)
Unique Ligands	NA, NAG

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4JS0 \| pdb_00004js0	Download File View File

Complex of Cdc42 with the CRIB-PR domain of IRSp53

Kast, D.J., Dominguez, R.

(2014) Nat Struct Mol Biol 21: 413-422

Released	2014-03-05
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Brain-specific angiogenesis inhibitor 1-associated protein 2 (protein) Cell division control protein 42 homolog (protein)
Unique Ligands	GNP, MG, PE4

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1AT0 \| pdb_00001at0	Download File View File

17-kDA fragment of hedgehog C-terminal autoprocessing domain

Hall, T.M.T., Porter, J.A., Young, K.E., Koonin, E.V., Beachy, P.A., Leahy, D.J.

(1997) Cell 91: 85-97

Released	1997-11-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Drosophila melanogaster
Macromolecule	17-HEDGEHOG (protein)

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1B0R \| pdb_00001b0r	Download File View File

CRYSTAL STRUCTURE OF HLA-A*0201 COMPLEXED WITH A PEPTIDE WITH THE CARBOXYL-TERMINAL GROUP SUBSTITUTED BY A METHYL GROUP

Bouvier, M., Guo, H., Smith, K.J., Wiley, D.C.

(1998) Proteins 33: 97-106

Released	1999-11-25
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (HLA-A*0201) (protein) PROTEIN (INFLUENZA MATRIX PEPTIDE) (protein)

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1B1H \| pdb_00001b1h	Download File View File

OLIGO-PEPTIDE BINDING PROTEIN/TRIPEPTIDE (LYS HPE LYS) COMPLEX

Davies, T.G., Tame, J.R.H.

(1999) Protein Sci 8: 1432-1444

Released	1998-11-18
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Salmonella enterica subsp. enterica serovar Typhimurium
Macromolecule	PROTEIN (LYS HPE LYS) (protein) PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN) (protein)
Unique Ligands	IUM

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1B5N \| pdb_00001b5n	Download File View File

NMR STRUCTURE OF PSP1, PLASMATOCYTE-SPREADING PEPTIDE FROM PSEUDOPLUSIA INCLUDENS

Volkman, B.F., Clark, K.D., Anderson, M.E., Pech, L.L., Markley, J.L., Strand, M.R.

(1999) J Biological Chem 274: 4493-4496

Released	1999-01-13
Method	SOLUTION NMR
Organisms	Chrysodeixis includens
Macromolecule	PROTEIN (PLASMATOCYTE-SPREADING PEPTIDE) (protein)

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1B9X \| pdb_00001b9x	Download File View File

STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN

Gaudet, R., Sigler, P.B.

(1999) Mol Cell 3: 649-660

Released	1999-02-23
Method	X-RAY DIFFRACTION 3 Å
Organisms	Bos taurus Rattus norvegicus
Macromolecule	PROTEIN (PHOSDUCIN) (protein) PROTEIN (TRANSDUCIN) (protein)
Unique Ligands	GD

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1B9Y \| pdb_00001b9y	Download File View File

STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA

Gaudet, R., Sigler, P.B.

(1999) Mol Cell 3: 649-660

Released	1999-02-23
Method	X-RAY DIFFRACTION 3 Å
Organisms	Bos taurus Rattus norvegicus
Macromolecule	PROTEIN (PHOSDUCIN) (protein) PROTEIN (TRANSDUCIN) (protein)
Unique Ligands	GD

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1BM7 \| pdb_00001bm7	Download File View File

HUMAN TRANSTHYRETIN (PREALBUMIN) COMPLEX WITH FLUFENAMIC ACID (2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID)

Klabunde, T., Kelly, J.W., Sacchettini, J.C.

(1998) Proc Natl Acad Sci U S A 95: 12956-12960

Released	1998-08-05
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (TRANSTHYRETIN) (protein)
Unique Ligands	FLF

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1BO0 \| pdb_00001bo0	Download File View File

MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE

Kwon, D., Lee, D., Sykes, B.D., Kim, K.-S.

(1996) FEBS Lett 395: 277-282

Released	1999-10-10
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	PROTEIN (MONOCYTE CHEMOATTRACTANT PROTEIN-3) (protein)

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1BQU \| pdb_00001bqu	Download File View File

CYTOKYNE-BINDING REGION OF GP130

Bravo, J., Staunton, D., Heath, J.K., Jones, E.Y.

(1998) EMBO J 17: 1665-1674

Released	1998-08-26
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (GP130) (protein)
Unique Ligands	GOL, SO4

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1BT0 \| pdb_00001bt0	Download File View File

STRUCTURE OF UBIQUITIN-LIKE PROTEIN, RUB1

Delacruz, W.P., Fisher, A.J.

(1998) J Biological Chem 273: 34976-34982

Released	1998-12-30
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Arabidopsis thaliana
Macromolecule	PROTEIN (UBIQUITIN-LIKE PROTEIN 7, RUB1) (protein)
Unique Ligands	EDO, ZN