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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 3.6.4.12

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Search Summary

This query matches 24 Structures.

Refinements

Structure Determination Methodology

experimental (24)

Scientific Name of Source Organism

Acinetobacter baumannii (24)

Taxonomy

Bacteria (24)

Experimental Method

X-RAY DIFFRACTION (24)

Polymer Entity Type

Protein (24)

Refinement Resolution (Å)

	1.0 - 1.5 (3)
	1.5 - 2.0 (11)
	2.0 - 2.5 (8)
	2.5 - 3.0 (2)

Release Date

	2010 - 2014 (5)
	2015 - 2019 (7)
	2020 - 2024 (12)

Enzyme Classification Name

Hydrolases (19)

Symmetry Type

Asymmetric (24)

SCOP Classification

Multi-domain proteins (alpha and beta) (12)

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1 to 24 of 24 Structures

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3MBZ \| pdb_00003mbz	Download File View File

OXA-24 beta-lactamase complex soaked with 10mM SA4-17 inhibitor for 15min

Sampson, J., van den Akker, F.

(2010) J Am Chem Soc 132: 13320-13331

Released	2011-03-16
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Acinetobacter baumannii
Macromolecule	Betalactamase OXA24 (protein)
Unique Ligands	MXC, SO4

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3PAE \| pdb_00003pae	Download File View File

Crystal structure of the K84D mutant of OXA-24/40 in complex with doripenem

Powers, R.A., Leonard, D.A., Schneider, K.D.

(2011) J Mol Biology 406: 583-594

Released	2011-01-19
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	4J6, SO4

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3PAG \| pdb_00003pag	Download File View File

Crystal structure of the V130D mutant of OXA-24/40 in complex with doripenem

Powers, R.A., Leonard, D.A., Schneider, K.D.

(2011) J Mol Biology 406: 583-594

Released	2011-01-19
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	4J6, SO4

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4F94 \| pdb_00004f94	Download File View File

Structure of the Class D Beta-Lactamase OXA-24 K84D in Acyl-Enzyme Complex with Oxacillin

June, C.M., Vallier, B.C., Bonomo, R.A., Leonard, D.A., Powers, R.A.

To be published

Released	2013-08-14
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	1S6, SO4

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4WM9 \| pdb_00004wm9	Download File View File

Acinetobacter baumanii OXA-24 complex with Avibactam

Mangani, S., Benvenuti, M., Docquier, J.-D.

(2015) ACS Chem Biol 10: 591-600

Released	2014-12-03
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	CO2, EDO, NXL, SO4

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5TG4 \| pdb_00005tg4	Download File View File

OXA-24/40 in Complex with Boronic Acid BA16

Powers, R.A., Werner, J.P., Mitchell, J.M.

(2017) Protein Sci 26: 515-526

Released	2017-01-11
Method	X-RAY DIFFRACTION 1.44 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	3GR, BCT, JW1, MEE, SO4

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5TG5 \| pdb_00005tg5	Download File View File

OXA-24/40 in Complex with Boronic Acid BA8

Powers, R.A., Werner, J.P., Mitchell, J.M.

(2017) Protein Sci 26: 515-526

Released	2017-01-11
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	BCT, JW8, MEE, SO4

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5TG6 \| pdb_00005tg6	Download File View File

OXA-24/40 in Complex with Boronic Acid BA4

Powers, R.A., Werner, J.P., Mitchell, J.M.

(2017) Protein Sci 26: 515-526

Released	2017-01-11
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	BCT, J4W, SO4

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5TG7 \| pdb_00005tg7	Download File View File

OXA-24/40 in Complex with Boronic Acid BA3

Powers, R.A., Werner, J.P., Mitchell, J.M.

(2017) Protein Sci 26: 515-526

Released	2017-01-11
Method	X-RAY DIFFRACTION 2.28 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	BCT, JW3, MEE, SO4

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5VFD \| pdb_00005vfd	Download File View File

Diazabicyclooctenone ETX2514 bound to Class D beta lactamase OXA-24 from A. baumannii

Olivier, N.B., Lahiri, S.

(2017) Nat Microbiol 2: 17104-17104

Released	2017-06-07
Method	X-RAY DIFFRACTION 1.93 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	9CM, 9CP, SO4

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6B22 \| pdb_00006b22	Download File View File

Crystal structure OXA-24 beta-lactamase complexed with WCK 4234 by co-crystallization

van den Akker, F., Nguyen, N.Q.

(2018) J Med Chem 61: 4067-4086

Released	2018-08-01
Method	X-RAY DIFFRACTION 1.93 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	C8Y, CL

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6MPQ \| pdb_00006mpq	Download File View File

1.95 Ang crystal structure of OXA-24/40 beta-lactamase in complex the inhibitor ETX2514

van den Akker, F., Kumar, V.

(2019) mBio 10:

Released	2019-02-27
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	CL, JXG

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7RP8 \| pdb_00007rp8	Download File View File

X-ray crystal structure of OXA-24/40 K84D in complex with imipenem

Powers, R.A., Mitchell, J.M., June, C.M.

(2022) J Biological Chem 298: 102127-102127

Released	2022-07-06
Method	X-RAY DIFFRACTION 2.28 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	ID1, SO4

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7RP9 \| pdb_00007rp9	Download File View File

X-ray crystal structure of OXA-24/40 V130D in complex with imipenem

Powers, R.A., Mitchell, J.M., June, C.M.

(2022) J Biological Chem 298: 102127-102127

Released	2022-07-06
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	BCT, HIW, ID1, SO4

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7RPA \| pdb_00007rpa	Download File View File

X-ray crystal structure of OXA-24/40 K84D in complex with meropenem

Powers, R.A., Mitchell, J.M., June, C.M.

(2022) J Biological Chem 298: 102127-102127

Released	2022-07-06
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Acinetobacter baumannii
Macromolecule	Beta-lactamase (protein)
Unique Ligands	BCT, MER, PEG, SO4