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234,785 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 2.1.1.359

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Search Summary

This query matches 62 Structures.

Refinements

Structure Determination Methodology

experimental (62)

Scientific Name of Source Organism

	Homo sapiens (57)
	synthetic construct (9)
	Xenopus laevis (7)
	Sus scrofa (4)
	Saccharomyces cerevisiae (3)
	Saccharomyces cerevisiae S288C (2)
	Thermochaetoides thermophila DSM 1495 (2)
	Mus musculus (1)

Taxonomy

	Eukaryota (62)
	other sequences (9)

Experimental Method

	X-RAY DIFFRACTION (46)
	ELECTRON MICROSCOPY (8)
	SOLUTION NMR (8)

Polymer Entity Type

	Protein (62)
	DNA (11)
	RNA (4)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (17)
	2.0 - 2.5 (20)
	2.5 - 3.0 (8)
	3.0 - 3.5 (5)
	3.5 - 4.0 (2)
	4.0 - 4.5 (1)

Release Date

	2000 - 2004 (1)
	2005 - 2009 (3)
	2010 - 2014 (9)
	2015 - 2019 (25)
	2020 - 2024 (19)
	2025 - 2029 (5)

Enzyme Classification Name

Transferases (62)

Symmetry Type

	Asymmetric (60)
	Cyclic (3)

SCOP Classification

	Membrane and cell surface proteins and peptides (11)
	Artifacts (4)
	All alpha proteins (1)
	All beta proteins (1)

AllSelected

1 to 25 of 62 Structures

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1E0N \| pdb_00001e0n	Download File View File

YJQ8WW domain from Saccharomyces cerevisae

Macias, M.J., Gervais, V., Civera, C., Oschkinat, H.

(2000) Nat Struct Biol 7: 375

Released	2000-06-02
Method	SOLUTION NMR
Organisms	Saccharomyces cerevisiae
Macromolecule	HYPOTHETICAL PROTEIN (protein)

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2A7O \| pdb_00002a7o	Download File View File

Solution Structure of the hSet2/HYPB SRI domain

Li, M., Phatnani, H.P., Guan, Z., Sage, H., Greenleaf, A., Zhou, P.

(2005) Proc Natl Acad Sci U S A 102: 17636-17641

Released	2005-11-01
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Huntingtin interacting protein B (protein)

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2BQZ \| pdb_00002bqz	Download File View File

Crystal structure of a ternary complex of the human histone methyltransferase Pr-SET7 (also known as SET8)

Xiao, B., Jing, C., Kelly, G., Walker, P.A., Muskett, F.W., Frenkiel, T.A., Martin, S.R., Sarma, K., Reinberg, D., Gamblin, S.J., Wilson, J.R.

(2005) Genes Dev 19: 1444

Released	2005-06-08
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	HISTONE H4 (protein) SET8 PROTEIN (protein)
Unique Ligands	SAH

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2C5Z \| pdb_00002c5z	Download File View File

Structure and CTD binding of the Set2 SRI domain

Vojnic, E., Simon, B., Strahl, B.D., Sattler, M., Cramer, P.

(2006) J Biological Chem 281: 13-15

Released	2005-11-14
Method	SOLUTION NMR
Organisms	Saccharomyces cerevisiae
Macromolecule	SET DOMAIN PROTEIN 2 (protein)

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2MDC \| pdb_00002mdc	Download File View File

Solution structure of the WW domain of HYPB

Gao, Y.G.

(2014) Structure 22: 378-386

Released	2014-09-10
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase SETD2 (protein)

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2MDI \| pdb_00002mdi	Download File View File

Solution structure of the PP2WW mutant (KPP2WW) of HYPB

Gao, Y.G., Hu, H.Y.

(2014) Structure 22: 378-386

Released	2014-09-10
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase SETD2 (protein)

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2MDJ \| pdb_00002mdj	Download File View File

Solution structure of WW domain with polyproline stretch (PP2WW) of HYPB

Gao, Y., Hu, H.

(2014) Structure 22: 378-386

Released	2014-09-10
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase SETD2 (protein)

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3MQM \| pdb_00003mqm	Download File View File

Crystal Structure of the Bromodomain of human ASH1L

Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Vollmar, M., Chaikuad, A., Krojer, T., Canning, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2012) Cell 149: 214-231

Released	2010-05-19
Method	X-RAY DIFFRACTION 2.54 Å
Organisms	Homo sapiens
Macromolecule	Probable histone-lysine N-methyltransferase ASH1L (protein)

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3OPE \| pdb_00003ope	Download File View File

Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase

An, S., Song, J.

(2011) J Biological Chem 286: 8369-8374

Released	2011-01-12
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Probable histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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4C1Q \| pdb_00004c1q	Download File View File

Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.

Mathioudakis, N., Cusack, S., Kadlec, J.

(2013) Cell Rep 5: 13

Released	2013-10-16
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	HISTONE H3.1 (protein) HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9 (protein)
Unique Ligands	GOL, SAH, ZN

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4FMU \| pdb_00004fmu	Download File View File

Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF

Dong, A., Zeng, H., Ibanez, G., Zheng, W., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)

(2012) J Am Chem Soc 134: 18004-18014

Released	2012-09-05
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase SETD2 (protein)
Unique Ligands	0UM, UNX, ZN

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4H12 \| pdb_00004h12	Download File View File

The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine

Amaya, M.F., Dong, A., Zeng, H., Mackenzie, F., Bunnage, M., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Wu, H., Structural Genomics Consortium (SGC)

(2012) J Am Chem Soc 134: 18004-18014

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase SETD2 (protein)
Unique Ligands	CL, SAH, ZN

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4IJD \| pdb_00004ijd	Download File View File

Crystal structure of methyltransferase domain of human PR domain-containing protein 9

Dong, A., Dombrovski, L., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)

To be published

Released	2013-02-13
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase PRDM9 (protein)
Unique Ligands	UNX, ZN

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4YNM \| pdb_00004ynm	Download File View File

ASH1L wild-type SET domain in complex with S-adenosyl methionine (SAM)

Rogawski, D.S., Ndoj, J., Cho, H.-J., Maillard, I., Grembecka, J., Cierpicki, T.

(2015) Biochemistry 54: 5401-5413

Released	2015-09-02
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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4YNP \| pdb_00004ynp	Download File View File

ASH1L SET domain S2259M mutant in complex with S-adenosyl methionine (SAM)

Rogawski, D.S., Ndoj, J., Cho, H.-J., Maillard, I., Grembecka, J., Cierpicki, T.

(2015) Biochemistry 54: 5401-5413

Released	2015-09-02
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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4YPA \| pdb_00004ypa	Download File View File

ASH1L SET domain Q2265A mutant in complex with S-adenosyl methionine (SAM)

Rogawski, D.S., Ndoj, J., Cho, H.J., Maillard, I., Grembecka, J., Cierpicki, T.

(2015) Biochemistry 54: 5401-5413

Released	2015-09-02
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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4YPE \| pdb_00004ype	Download File View File

ASH1L SET domain H2193F mutant in complex with S-adenosyl methionine (SAM)

Rogawski, D.S., Ndoj, J., Cho, H.J., Maillard, I., Grembecka, J., Cierpicki, T.

(2015) Biochemistry 54: 5401-5413

Released	2015-09-02
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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4YPU \| pdb_00004ypu	Download File View File

ASH1L SET domain K2264L mutant in complex with S-adenosyl methionine (SAM)

Rogawski, D.S., Ndoj, J., Cho, H.J., Maillard, I., Grembecka, J., Cierpicki, T.

(2015) Biochemistry 54: 5401-5413

Released	2015-09-02
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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5EGB \| pdb_00005egb	Download File View File

Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence II

Patel, A., Horton, J.R., Wilson, G.G., Zhang, X., Cheng, X.

(2016) Genes Dev 30: 257-265

Released	2016-02-17
Method	X-RAY DIFFRACTION 1.977 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase PRDM9 (protein) DNA (5'-D(APCPCPAPCPGPTPGPGPCPTPAPGPGPGPAPGPGPCPCPT)-3') (nucleic acid) DNA (5'-D(TPAPGPGPCPCPTPCPCPCPTPAPGPCPCPAPCPGPTPGPG)-3') (nucleic acid)
Unique Ligands	ZN

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5EH2 \| pdb_00005eh2	Download File View File

Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence III

Patel, A., Horton, J.R., Wilson, G.G., Zhang, X., Cheng, X.

(2016) Genes Dev 30: 257-265

Released	2016-02-17
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase PRDM9 (protein) DNA (5'-D(APCPAPCPGPTPGPGPCPTPAPGPGPGPAPGPGPCPCPTPC)-3') (nucleic acid) DNA (5'-D(TPGPAPGPGPCPCPTPCPCPCPTPAPGPCPCPAPCPGPTPG)-3') (nucleic acid)
Unique Ligands	ZN

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5EI9 \| pdb_00005ei9	Download File View File

Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence I

Patel, A., Horton, J.R., Wilson, G.G., Zhang, X., Cheng, X.

(2016) Genes Dev 30: 257-265

Released	2016-02-17
Method	X-RAY DIFFRACTION 1.921 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase PRDM9 (protein) DNA (5'-D(APTPCPCPAPCPGPTPGPGPCPTPAPGPGPGPAPGPGPCPC)-3') (nucleic acid) DNA (5'-D(TPGPGPCPCPTPCPCPCPTPAPGPCPCPAPCPGPTPGPGPA)-3') (nucleic acid)
Unique Ligands	ZN

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5JJY \| pdb_00005jjy	Download File View File

Crystal structure of SETD2 bound to histone H3.3 K36M peptide

Yang, S., Zheng, X., Li, H.

(2016) Genes Dev 30: 1611-1616

Released	2016-11-02
Method	X-RAY DIFFRACTION 2.053 Å
Organisms	Homo sapiens
Macromolecule	Histone H3.3 (protein) Histone-lysine N-methyltransferase SETD2 (protein)
Unique Ligands	SAH, SCN, ZN

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5JLB \| pdb_00005jlb	Download File View File

Crystal structure of SETD2 bound to histone H3.3 K36I peptide

Li, H., Yang, S.

(2016) Genes Dev 30: 1611-1616

Released	2016-11-02
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Histone H3.3 (protein) Histone-lysine N-methyltransferase SETD2 (protein)
Unique Ligands	GOL, SAH, SCN, ZN

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5JLE \| pdb_00005jle	Download File View File

Crystal structure of SETD2 bound to SAH

Li, H., Yang, S., Zheng, X.

(2016) Genes Dev 30: 1611-1616

Released	2016-11-02
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase SETD2 (protein)
Unique Ligands	SAH, ZN

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5LSS \| pdb_00005lss	Download File View File

Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives

Tisi, D., Pathuri, P.

(2016) ACS Chem Biol 11: 3093-3105

Released	2016-10-05
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase SETD2 (protein)
Unique Ligands	76H, SCN, ZN

1 to 25 of 62 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1E0N | pdb_00001e0n

2A7O | pdb_00002a7o

2BQZ | pdb_00002bqz

2C5Z | pdb_00002c5z

2MDC | pdb_00002mdc

2MDI | pdb_00002mdi

2MDJ | pdb_00002mdj

3MQM | pdb_00003mqm

3OPE | pdb_00003ope

4C1Q | pdb_00004c1q

4FMU | pdb_00004fmu

4H12 | pdb_00004h12

4IJD | pdb_00004ijd

4YNM | pdb_00004ynm

4YNP | pdb_00004ynp

4YPA | pdb_00004ypa

4YPE | pdb_00004ype

4YPU | pdb_00004ypu

5EGB | pdb_00005egb

5EH2 | pdb_00005eh2

5EI9 | pdb_00005ei9

5JJY | pdb_00005jjy

5JLB | pdb_00005jlb

5JLE | pdb_00005jle

5LSS | pdb_00005lss