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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "ilvC"

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Search Summary

This query matches 39 Structures.

Refinements

Structure Determination Methodology

experimental (39)

Scientific Name of Source Organism

	Campylobacter jejuni (6)
	Staphylococcus aureus (6)
	Streptococcus pneumoniae D39 (5)
	Staphylococcus aureus RF122 (4)
	Ignisphaera aggregans DSM 17230 (3)
	Slackia exigua ATCC 700122 (2)
	Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 (1)
	Campylobacter jejuni RM1221 (1)
	Campylobacter jejuni subsp. jejuni (1)
	Candidatus Methanophaga sp. (1)

More...

Taxonomy

	Bacteria (33)
	Archaea (5)
	Eukaryota (1)

Experimental Method

	X-RAY DIFFRACTION (37)
	ELECTRON MICROSCOPY (2)

Polymer Entity Type

Protein (39)

Refinement Resolution (Å)

	1.0 - 1.5 (5)
	1.5 - 2.0 (11)
	2.0 - 2.5 (10)
	2.5 - 3.0 (10)
	3.0 - 3.5 (3)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (4)
	2015 - 2019 (12)
	2020 - 2024 (20)
	2025 - 2029 (2)

Enzyme Classification Name

Oxidoreductases (39)

Symmetry Type

	Cyclic (31)
	Dihedral (3)
	Tetrahedral (4)
	Asymmetric (2)

SCOP Classification

	All alpha proteins (20)
	Alpha and beta proteins (a/b) (20)
	Artifacts (1)

AllSelected

1 to 25 of 39 Structures

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1YRL \| pdb_00001yrl	Download File View File

Escherichia coli ketol-acid reductoisomerase

Tyagi, R., Duquerroy, S., Navaza, J., Guddat, L.W., Duggleby, R.G.

(2005) Protein Sci 14: 3089-3100

Released	2005-10-11
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	SO4

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3ULK \| pdb_00003ulk	Download File View File

E. coli Ketol-acid reductoisomerase in complex with NADPH and Mg2+

Wong, S.H., Lonhienne, T.G.A., Winzor, D.J., Schenk, G., Guddat, L.W.

(2012) J Mol Biology 424: 168-179

Released	2012-10-17
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Escherichia coli K-12
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	MG, NDP, SO4

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4KQW \| pdb_00004kqw	Download File View File

The structure of the Slackia exigua KARI in complex with NADP

Brinkmann-Chen, S., Flock, T., Cahn, J.K.B., Snow, C.D., Brustad, E.M., Mcintosh, J.A., Meinhold, P., Zhang, L., Arnold, F.H.

(2013) Proc Natl Acad Sci U S A 110: 10946-10951

Released	2013-06-26
Method	X-RAY DIFFRACTION 1.39 Å
Organisms	Slackia exigua ATCC 700122
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	MG, NAP, TLA

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4KQX \| pdb_00004kqx	Download File View File

Mutant Slackia exigua KARI DDV in complex with NAD and an inhibitor

Brinkmann-Chen, S., Flock, T., Cahn, J.K.B., Snow, C.D., Brustad, E.M., Mcintosh, J.A., Meinhold, P., Zhang, L., Arnold, F.H.

(2013) Proc Natl Acad Sci U S A 110: 10946-10951

Released	2013-06-26
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Slackia exigua ATCC 700122
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	HIO, HIS, MG, NAD

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4TSK \| pdb_00004tsk	Download File View File

Ketol-acid reductoisomerase from Alicyclobacillus acidocaldarius

Cahn, J.K.B., Brinkmann-Chen, S., Arnold, F.H.

(2014) Metab Eng 26C: 17-22

Released	2014-07-09
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	MG, NDP, TLA

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4XDY \| pdb_00004xdy	Download File View File

Structure of NADH-preferring ketol-acid reductoisomerase from an uncultured archean

Cahn, J.K.B., Brinkmann-Chen, S., Arnold, F.H.

(2015) Biochem J 468: 475-484

Released	2015-04-22
Method	X-RAY DIFFRACTION 1.535 Å
Organisms	Candidatus Methanophaga sp.
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	GOL, HIO, MG, NAI

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4XDZ \| pdb_00004xdz	Download File View File

Holo structure of ketol-acid reductoisomerase from Ignisphaera aggregans

Cahn, J.K.B., Brinkmann-Chen, S., Arnold, F.H.

(2015) Biochem J 468: 475-484

Released	2015-04-22
Method	X-RAY DIFFRACTION 1.15 Å
Organisms	Ignisphaera aggregans DSM 17230
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	40E, EPE, GOL, MG, NDP

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4XEH \| pdb_00004xeh	Download File View File

Apo structure of KARI from Ignisphaera aggregans

Cahn, J.K.B., Brinkmann-Chen, S., Arnold, F.H.

(2015) Biochem J 468: 475-484

Released	2015-04-22
Method	X-RAY DIFFRACTION 1.391 Å
Organisms	Ignisphaera aggregans DSM 17230
Macromolecule	Ketol-acid reductoisomerase (protein)

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4YPO \| pdb_00004ypo	Download File View File

Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase in complex with Mg2+

Lv, Y., Guddat, L.W.

(2016) FEBS J 283: 1184-1196

Released	2016-02-17
Method	X-RAY DIFFRACTION 1.001 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	CL, MG, NA

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5E4R \| pdb_00005e4r	Download File View File

Crystal structure of domain-duplicated synthetic class II ketol-acid reductoisomerase 2Ia_KARI-DD

Cahn, J.K.B., Brinkmann-Chen, S., Buller, A.R., Arnold, F.H.

(2016) Protein Sci 25: 1241-1248

Released	2015-12-23
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Ignisphaera aggregans DSM 17230
Macromolecule	Ketol-acid reductoisomerase (protein)
Unique Ligands	40E, EDO, GOL, MG, NAP

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5W3K \| pdb_00005w3k	Download File View File

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex NADPH, Mg2+ and CPD

Patel, K.M., Teran, D., Zheng, S., Kandale, A., Schembri, M., McGeary, R.P., Schenk, G., Guddat, L.W.

(2017) Chemistry 23: 18289-18295

Released	2017-10-25
Method	X-RAY DIFFRACTION 1.589 Å
Organisms	Staphylococcus aureus
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	9TY, MG, NDP

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5YEQ \| pdb_00005yeq	Download File View File

The structure of Sac-KARI protein

Ko, T.P., Chen, C.Y., Lin, K.F., Lin, B.L., Huang, C.H., Chiang, C.H., Horng, J.C., Tsai, M.D.

(2018) Sci Rep 8: 7176-7176

Released	2018-07-04
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Sulfolobus acidocaldarius
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	EDO, MG, SO4

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6AQJ \| pdb_00006aqj	Download File View File

Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity.

Patel, K.M., Teran, D., Zheng, S., Gracia, M., Lv, Y., Schembri, M.A., McGeary, R.P., Schenk, G., Guddat, L.W.

(2017) Chemistry 23: 18289-18295

Released	2017-10-18
Method	X-RAY DIFFRACTION 1.373 Å
Organisms	Staphylococcus aureus RF122
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	40E, EDO, GOL, HIO, MG, NDP

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6BUL \| pdb_00006bul	Download File View File

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 2

Kandale, A., Patel, K.M., Zheng, S., You, L., Guddat, L.W., Schenk, G., Schembri, M.A., McFeary, R.P.

To be published

Released	2018-12-12
Method	X-RAY DIFFRACTION 1.88 Å
Organisms	Staphylococcus aureus RF122
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	E9G, E9J, MG, NAP

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6C55 \| pdb_00006c55	Download File View File

Crystal structure of Staphylococcus aureus Ketol-acid Reductosimerrase with hydroxyoxamate inhibitor 3

Kandale, A., Patel, K.M., Zheng, S., You, L., Guddat, L.W., Schenk, G., Schmbri, M., McGeary, R.P.

To be published

Released	2019-01-16
Method	X-RAY DIFFRACTION 2.09 Å
Organisms	Staphylococcus aureus RF122
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	EKA, EKD, MG, NAP

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6C5N \| pdb_00006c5n	Download File View File

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 1

Kandale, A., Patel, K.M., Zheng, S., You, L., Guddat, L.W., Schenk, G., Schembri, M.A., McGeary, R.P.

To be published

Released	2019-01-30
Method	X-RAY DIFFRACTION 1.673 Å
Organisms	Staphylococcus aureus RF122
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	81B, EN4, IMD, MG, NDP

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6JX2 \| pdb_00006jx2	Download File View File

Crystal structure of Ketol-acid reductoisomerase from Corynebacterium glutamicum

Lee, D., Hong, J., Kim, K.-J.

(2019) J Agric Food Chem 67: 8527-8535

Released	2019-08-07
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Corynebacterium glutamicum ATCC 13032
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	EDO, MG, NAP

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6L2I \| pdb_00006l2i	Download File View File

IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_WT

Gyuhee, K., Donghyuk, S., Sumin, L., Jaesook, Y., Sangho, L.

(2019) Crystals (Basel) 9:

Released	2020-08-12
Method	X-RAY DIFFRACTION 1.69 Å
Organisms	Streptococcus pneumoniae D39
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	GOL, MG, NAP, SO4

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6L2K \| pdb_00006l2k	Download File View File

IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_R49E

Gyuhee, K., Donghyuk, S., Sumin, L., Jaesook, Y., Sangho, L.

(2019) Crystals (Basel) 9:

Released	2020-08-12
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Streptococcus pneumoniae D39
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	GOL, SO4

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6L2R \| pdb_00006l2r	Download File View File

IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_E195S

Gyuhee, K., Donghyuk, S., Sumin, L., Jaesook, Y., Sangho, L.

(2019) Crystals (Basel) 9:

Released	2020-08-12
Method	X-RAY DIFFRACTION 2.02 Å
Organisms	Streptococcus pneumoniae D39
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)

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6L2S \| pdb_00006l2s	Download File View File

IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_D83G

Gyuhee, K., Donghyuk, S., Sumin, L., Jaesook, Y., Sangho, L.

(2019) Crystals (Basel) 9:

Released	2020-08-12
Method	X-RAY DIFFRACTION 2.29 Å
Organisms	Streptococcus pneumoniae D39
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)

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6L2Z \| pdb_00006l2z	Download File View File

IlvC, a ketol-acid reductoisomerase, from Streptococcus pnuemoniae_D191G

Gyuhee, K., Donghyuk, S., Sumin, L., Jaesook, Y., Sangho, L.

(2019) Crystals (Basel) 9:

Released	2020-08-12
Method	X-RAY DIFFRACTION 2.02 Å
Organisms	Streptococcus pneumoniae D39
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	GOL, NAP, NH4, SO4

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6VO2 \| pdb_00006vo2	Download File View File

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg, NADPH and inhibitor.

Bayaraa, T., Patel, K.M., Guddat, L.W.

(2020) Chemistry 26: 8958-8968

Released	2020-04-08
Method	X-RAY DIFFRACTION 1.59 Å
Organisms	Staphylococcus aureus
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	MG, NDP, R67

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7KE2 \| pdb_00007ke2	Download File View File

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg2+ and NSC116565

Kurz, J.L., Patel, K.P., Guddat, L.W.

(2021) Chemistry 27: 3130-3141

Released	2021-07-14
Method	X-RAY DIFFRACTION 2.59 Å
Organisms	Staphylococcus aureus
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	MG, WBY

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7KH7 \| pdb_00007kh7	Download File View File

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg2+, NADPH, and NSC116565

Kurz, J.L., Patel, K.P., Guddat, L.W.

(2021) Chemistry 27: 3130-3141

Released	2021-07-14
Method	X-RAY DIFFRACTION 2.63 Å
Organisms	Staphylococcus aureus
Macromolecule	Ketol-acid reductoisomerase (NADP(+)) (protein)
Unique Ligands	MG, NAP, NDP, WBY

1 to 25 of 39 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1YRL | pdb_00001yrl

3ULK | pdb_00003ulk

4KQW | pdb_00004kqw

4KQX | pdb_00004kqx

4TSK | pdb_00004tsk

4XDY | pdb_00004xdy

4XDZ | pdb_00004xdz

4XEH | pdb_00004xeh

4YPO | pdb_00004ypo

5E4R | pdb_00005e4r

5W3K | pdb_00005w3k

5YEQ | pdb_00005yeq

6AQJ | pdb_00006aqj

6BUL | pdb_00006bul

6C55 | pdb_00006c55

6C5N | pdb_00006c5n

6JX2 | pdb_00006jx2

6L2I | pdb_00006l2i

6L2K | pdb_00006l2k

6L2R | pdb_00006l2r

6L2S | pdb_00006l2s

6L2Z | pdb_00006l2z

6VO2 | pdb_00006vo2

7KE2 | pdb_00007ke2

7KH7 | pdb_00007kh7