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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "EDG2"

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Search Summary

This query matches 35 Structures.

Refinements

Structure Determination Methodology

experimental (35)

Scientific Name of Source Organism

	La Crosse virus (10)
	Chikungunya virus strain S27-African prototype (9)
	CAS virus (4)
	Mammarenavirus lassaense (3)
	Sus scrofa (3)
	Toscana virus (3)
	Orthobunyavirus lacrosseense (2)
	Hantaan virus 76-118 (1)
	Mus musculus (1)
	Orthohantavirus hantanense (1)

More...

Taxonomy

	Riboviria (33)
	Eukaryota (5)
	other sequences (1)

Experimental Method

	X-RAY DIFFRACTION (24)
	ELECTRON MICROSCOPY (11)

Polymer Entity Type

	Protein (35)
	RNA (6)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (8)
	2.0 - 2.5 (8)
	2.5 - 3.0 (10)
	3.0 - 3.5 (7)
	3.5 - 4.0 (1)

Release Date

	2010 - 2014 (6)
	2015 - 2019 (16)
	2020 - 2024 (13)

Enzyme Classification Name

	Transferases (25)
	Hydrolases (23)

Symmetry Type

	Asymmetric (19)
	Cyclic (10)
	Dihedral (4)
	Helical (2)

SCOP Classification

	All beta proteins (3)
	All alpha proteins (2)
	Alpha and beta proteins (a+b) (2)
	Artifacts (1)

AllSelected

1 to 25 of 35 Structures

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2XI5 \| pdb_00002xi5	Download File View File

N-terminal endonuclease domain of La Crosse virus L-protein

Reguera, J., Weber, F., Cusack, S.

(2010) PLoS Pathog 6: 1101

Released	2010-10-06
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	La Crosse virus
Macromolecule	RNA POLYMERASE L (protein)
Unique Ligands	MN

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2XI7 \| pdb_00002xi7	Download File View File

N-terminal endonuclease domain of La Crosse virus L-protein

Reguera, J., Weber, F., Cusack, S.

(2010) PLoS Pathog 6: 1101

Released	2010-10-06
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	La Crosse virus
Macromolecule	RNA POLYMERASE L (protein)
Unique Ligands	MN, XI7

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4BGP \| pdb_00004bgp	Download File View File

Crystal structure of La Crosse virus nucleoprotein

Reguera, J., Malet, H., Weber, F., Cusack, S.

(2013) Proc Natl Acad Sci U S A 110: 7246

Released	2013-04-24
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	La Crosse virus
Macromolecule	NUCLEOPROTEIN (protein)
Unique Ligands	GOL, SO4

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4BHH \| pdb_00004bhh	Download File View File

Crystal structure of tetramer of La Crosse virus nucleoprotein in complex with ssRNA

Reguera, J., Malet, H., Weber, F., Cusack, S.

(2013) Proc Natl Acad Sci U S A 110: 7246

Released	2013-04-24
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	La Crosse virus synthetic construct
Macromolecule	NUCLEOPROTEIN (protein) POLY-URIDINE 45-MER (nucleic acid)

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4F2M \| pdb_00004f2m	Download File View File

Crystal structure of a TGEV coronavirus Spike fragment in complex with the TGEV neutralizing monoclonal antibody 1AF10

Reguera, J., Santiago, C., Mudgal, G., Ordono, D., Enjuanes, L., Casasnovas, J.M.

(2012) PLoS Pathog 8: e1002859-e1002859

Released	2012-08-22
Method	X-RAY DIFFRACTION 3 Å
Organisms	Mus musculus TGEV virulent Purdue
Macromolecule	Spike protein (protein) monoclonal antibody 1AF10, heavy chain (protein) monoclonal antibody 1AF10, light chain (protein)
Unique Ligands	ACY, NAG
Unique branched monosaccharides	NAG

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4F5C \| pdb_00004f5c	Download File View File

Crystal structure of the spike receptor binding domain of a porcine respiratory coronavirus in complex with the pig aminopeptidase N ectodomain

Santiago, C., Reguera, J., Gaurav, M., Ordono, D., Enjuanes, L., Casasnovas, J.M.

(2012) PLoS Pathog 8: e1002859-e1002859

Released	2012-08-22
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Porcine respiratory coronavirus Sus scrofa
Macromolecule	Aminopeptidase N (protein) PRCV spike protein (protein)
Unique Ligands	NAG, ZN
Unique branched monosaccharides	NAG

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5AMQ \| pdb_00005amq	Download File View File

Structure of the La Crosse Bunyavirus polymerase in complex with the 3' and 5' viral RNA

Reguera, J., Gerlach, P., Cusack, S.

(2015) Cell 161: 1267-1279

Released	2015-06-03
Method	X-RAY DIFFRACTION 3 Å
Organisms	La Crosse virus
Macromolecule	RNA POLYMERASE L (protein) RNA (nucleic acid)

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5AMR \| pdb_00005amr	Download File View File

Structure of the La Crosse Bunyavirus polymerase in complex with the 3' viral RNA

Reguera, J., Gerlach, P., Cusack, S.

(2015) Cell 161: 1267

Released	2015-06-03
Method	X-RAY DIFFRACTION 2.57 Å
Organisms	La Crosse virus
Macromolecule	RNA POLYMERASE L (protein) RNA (nucleic acid)

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5IZE \| pdb_00005ize	Download File View File

Hantaan virus L protein cap-snatching endonuclease

Reguera, J., Cusack, S.

(2016) PLoS Pathog 12: e1005636-e1005636

Released	2016-06-29
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Hantaan virus 76-118
Macromolecule	RNA-directed RNA polymerase L (protein)
Unique Ligands	MN3

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5IZH \| pdb_00005izh	Download File View File

Lassa virus L protein cap-snatching endonuclease. apo form

Reguera, J., Cusack, S.

(2016) PLoS Pathog 12: e1005636-e1005636

Released	2016-06-29
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Mammarenavirus lassaense
Macromolecule	RNA-directed RNA polymerase L (protein)

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5J1N \| pdb_00005j1n	Download File View File

Lassa virus L protein cap-snatching endonuclease. Bound to one manganese ion

Reguera, J., Cusack, S.

(2016) PLoS Pathog 12: e1005636-e1005636

Released	2016-06-29
Method	X-RAY DIFFRACTION 1.09 Å
Organisms	Mammarenavirus lassaense
Macromolecule	RNA-directed RNA polymerase L (protein)
Unique Ligands	MN3, MPD

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5J1P \| pdb_00005j1p	Download File View File

Lassa virus L protein cap-snatching endonuclease. Bound to two manganese ions

Reguera, J., Cusack, S.

(2016) PLoS Pathog 12: e1005636-e1005636

Released	2016-06-29
Method	X-RAY DIFFRACTION 2.36 Å
Organisms	Mammarenavirus lassaense
Macromolecule	RNA-directed RNA polymerase L (protein)
Unique Ligands	MN3

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5LDS \| pdb_00005lds	Download File View File

Structure of the porcine aminopeptidase N ectodomain

Santiago, C., Reguera, J., Mudgal, G., Casasnovas, J.M.

(2017) Sci Rep 7: 46045-46045

Released	2017-04-05
Method	X-RAY DIFFRACTION 2 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	ACT, NAG, ZN
Unique branched monosaccharides	BMA, NAG

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5LG6 \| pdb_00005lg6	Download File View File

Structure of the deglycosylated porcine aminopeptidase N ectodomain

Santiago, C., Reguera, J., Mudgal, G., Casasnovas, J.M.

(2017) Sci Rep 7: 46045-46045

Released	2017-04-12
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Sus scrofa
Macromolecule	Aminopeptidase N (protein)
Unique Ligands	NAG, ZN

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5MUS \| pdb_00005mus	Download File View File

Structure of the C-terminal domain of a reptarenavirus L protein

Rosenthal, M., Gogrefe, N., Reguera, J., Vogel, D., Rauschenberger, B., Cusack, S., Gunther, S., Reindl, S.

(2017) PLoS Pathog 13: e1006400-e1006400

Released	2017-05-17
Method	X-RAY DIFFRACTION 2.009 Å
Organisms	CAS virus
Macromolecule	L protein (protein)
Unique Ligands	CL, GOL

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5MUY \| pdb_00005muy	Download File View File

Structure of a C-terminal domain of a reptarenavirus L protein with m7GTP

Rosenthal, M., Gogrefe, N., Reguera, J., Vogel, D., Rauschenberger, B., Cusack, S., Gunther, S., Reindl, S.

(2017) PLoS Pathog 13: e1006400-e1006400

Released	2017-05-17
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	CAS virus
Macromolecule	L protein (protein)
Unique Ligands	MGT

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5MUZ \| pdb_00005muz	Download File View File

Structure of a C-terminal domain of a reptarenavirus L protein

Rosenthal, M., Gogrefe, N., Reguera, J., Vogel, D., Rauschenberger, B., Cusack, S., Gunther, S., Reindl, S.

(2017) PLoS Pathog 13: e1006400-e1006400

Released	2017-05-17
Method	X-RAY DIFFRACTION 1.776 Å
Organisms	CAS virus
Macromolecule	L protein (protein)

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5MV0 \| pdb_00005mv0	Download File View File

Structure of an N-terminal domain of a reptarenavirus L protein

Rosenthal, M., Gogrefe, N., Reguera, J., Vogel, D., Rauschenberger, B., Cusack, S., Gunther, S., Reindl, S.

(2017) PLoS Pathog 13: e1006400-e1006400

Released	2017-05-17
Method	X-RAY DIFFRACTION 1.93 Å
Organisms	CAS virus
Macromolecule	L protein (protein)
Unique Ligands	PO4

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6I2N \| pdb_00006i2n	Download File View File

Helical RNA-bound Hantaan virus nucleocapsid

Arragain, B., Reguera, J., Desfosses, A., Gutsche, I., Schoehn, G., Malet, H.

(2019) Elife 8:

Released	2019-01-23
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Orthohantavirus hantanense Spodoptera frugiperda
Macromolecule	Nucleoprotein (protein) RNA (5'-R(PUPUP*U)-3') (nucleic acid)

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6QVV \| pdb_00006qvv	Download File View File

Structure and function of phenuiviridae cap snatching endonucleases

Reguera, J., Jones, R., Bragagniolo, G., Lessoued, S., Mate, M.

(2019) Nucleic Acids Res 47: 10914-10930

Released	2019-09-25
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Toscana virus
Macromolecule	RNA-dependent RNA polymerase (protein)
Unique Ligands	GOL, MN3, SO4

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6QW0 \| pdb_00006qw0	Download File View File

Structure and function of toscana virus cap snatching endonucleases

Reguera, J., Jones, R., Bragagniolo, G., Lessoued, S., Mate, M.

(2019) Nucleic Acids Res 47: 10914-10930

Released	2019-09-25
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Toscana virus
Macromolecule	RNA-dependent RNA polymerase (protein)
Unique Ligands	GOL, MN3, SO4

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6QW5 \| pdb_00006qw5	Download File View File

Structure and function of the toscana virus cap snatching endonuclease

Reguera, J., Jones, R., Bragagniolo, G., Lessoued, S., Mate, M.

(2019) Nucleic Acids Res 47: 10914-10930

Released	2019-09-25
Method	X-RAY DIFFRACTION 1.988 Å
Organisms	Toscana virus
Macromolecule	RNA-dependent RNA polymerase (protein)
Unique Ligands	MN, SO4, XI7

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6Z0U \| pdb_00006z0u	Download File View File

CryoEM structure of the Chikungunya virus nsP1 complex

Reguera, J., Jones, R., Arranz-Avila, R.

(2021) Nature 589: 615-619

Released	2020-10-14
Method	ELECTRON MICROSCOPY 2.9 Å
Organisms	Chikungunya virus strain S27-African prototype
Macromolecule	Polyprotein P1234 (protein)
Unique Ligands	ZN

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6Z0V \| pdb_00006z0v	Download File View File

CryoEM structure of the Chikungunya virus nsP1 complex

Reguera, J., Jones, R., Arranz-Avila, R.

(2021) Nature 589: 615-619

Released	2020-10-14
Method	ELECTRON MICROSCOPY 2.6 Å
Organisms	Chikungunya virus strain S27-African prototype
Macromolecule	Polyprotein P1234 (protein)
Unique Ligands	ZN

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6Z6B \| pdb_00006z6b	Download File View File

Structure of full-length La Crosse virus L protein (polymerase)

Cusack, S., Gerlach, P., Reguera, J.

(2020) Nat Commun 11: 3590-3590

Released	2020-07-29
Method	X-RAY DIFFRACTION 3.961 Å
Organisms	La Crosse virus Orthobunyavirus lacrosseense
Macromolecule	RNA-directed RNA polymerase L (protein) RNA (5'-R(GPCPUPAPCPUPAPA)-3') (nucleic acid) RNA (5'-R(PAPGPUPAPGPUPGPUPGPC)-3') (nucleic acid) RNA (5'-R(PUPUPAPGPUPAPGPUPAPCPAPCPUPAPCPU)-3') (nucleic acid)
Unique Ligands	ZN

1 to 25 of 35 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2XI5 | pdb_00002xi5

2XI7 | pdb_00002xi7

4BGP | pdb_00004bgp

4BHH | pdb_00004bhh

4F2M | pdb_00004f2m

4F5C | pdb_00004f5c

5AMQ | pdb_00005amq

5AMR | pdb_00005amr

5IZE | pdb_00005ize

5IZH | pdb_00005izh

5J1N | pdb_00005j1n

5J1P | pdb_00005j1p

5LDS | pdb_00005lds

5LG6 | pdb_00005lg6

5MUS | pdb_00005mus

5MUY | pdb_00005muy

5MUZ | pdb_00005muz

5MV0 | pdb_00005mv0

6I2N | pdb_00006i2n

6QVV | pdb_00006qvv

6QW0 | pdb_00006qw0

6QW5 | pdb_00006qw5

6Z0U | pdb_00006z0u

6Z0V | pdb_00006z0v

6Z6B | pdb_00006z6b