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234,785 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "CHRNB2"

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Search Summary

This query matches 15 Structures.

Refinements

Structure Determination Methodology

experimental (15)

Scientific Name of Source Organism

	Homo sapiens (15)
	Mus musculus (8)
	Escherichia coli (2)

Taxonomy

	Eukaryota (13)
	Bacteria (2)
	Eukaryota (eukaryotes) (2)

Experimental Method

	ELECTRON MICROSCOPY (10)
	SOLUTION NMR (4)
	X-RAY DIFFRACTION (1)

Polymer Entity Type

Protein (15)

Refinement Resolution (Å)

	2.0 - 2.5 (2)
	2.5 - 3.0 (3)
	3.0 - 3.5 (1)
	3.5 - 4.0 (5)

Release Date

	2005 - 2009 (2)
	2010 - 2014 (2)
	2015 - 2019 (3)
	2020 - 2024 (8)

Membrane Protein Annotation

	PDBTM (15)
	MemProtMD (13)
	OPM (8)
	mpstruc (5)

Symmetry Type

Asymmetric (15)

AllSelected

1 to 15 of 15 Structures

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2K58 \| pdb_00002k58	Download File View File

NMR structures of the first transmembrane domain of the neuronal acetylcholine receptor beta 2 subunit

Bondarenko, V., Tang, P., Xu, Y.

(2007) Biophys J 92: 1616-1622

Released	2008-07-08
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Neuronal acetylcholine receptor subunit beta-2 (protein)

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2K59 \| pdb_00002k59	Download File View File

NMR structures of the second transmembrane domain of the neuronal acetylcholine receptor beta 2 subunit

Bondarenko, V., Tang, P., Xu, Y., Yushmanov, V.

(2003) Biochemistry 42: 13058-13065

Released	2008-07-08
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Neuronal acetylcholine receptor subunit beta-2 (protein)

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2KSR \| pdb_00002ksr	Download File View File

NMR structures of TM domain of the n-Acetylcholine receptor b2 subunit

Bondarenko, V., Tillman, T., Xu, Y., Tang, P.

(2010) Biochim Biophys Acta 1798: 1608-1614

Released	2010-06-16
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Neuronal acetylcholine receptor subunit beta-2 (protein)

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2LM2 \| pdb_00002lm2	Download File View File

NMR structures of the transmembrane domains of the AChR b2 subunit

Bondarenko, V., Mowrey, D., Tillman, T., Cui, T., Liu, L.T., Xu, Y., Tang, P.

(2012) Biochim Biophys Acta 1818: 1261-1268

Released	2012-03-28
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Neuronal acetylcholine receptor subunit beta-2 (protein)

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5KXI \| pdb_00005kxi	Download File View File

X-ray structure of the human Alpha4Beta2 nicotinic receptor

Morales-Perez, C.L., Noviello, C.M., Hibbs, R.E.

(2016) Nature 538: 411-415

Released	2016-09-28
Method	X-RAY DIFFRACTION 3.941 Å
Organisms	Homo sapiens
Macromolecule	Neuronal acetylcholine receptor subunit alpha-4 (protein) Neuronal acetylcholine receptor subunit beta-2 (protein)
Unique Ligands	NA, NAG, NCT

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6CNJ \| pdb_00006cnj	Download File View File

Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor

Walsh Jr, R.M., Roh, S.H., Gharpure, A., Morales-Perez, C.L., Teng, J., Hibbs, R.E.

(2018) Nature 557: 261-265

Released	2018-05-02
Method	ELECTRON MICROSCOPY 3.7 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	IgG1 Heavy Chain (protein) IgG1 Kappa Light Chain (protein) Neuronal acetylcholine receptor subunit alpha-4 (protein) Neuronal acetylcholine receptor subunit beta-2 (protein)
Unique Ligands	NA, NAG, NCT, Y01
Unique branched monosaccharides	BMA, NAG

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6CNK \| pdb_00006cnk	Download File View File

Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor

Walsh Jr, R.M., Roh, S.H., Gharpure, A., Morales-Perez, C.L., Hibbs, R.E.

(2018) Nature 557: 261-265

Released	2018-05-02
Method	ELECTRON MICROSCOPY 3.9 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	IgG1 Heavy Chain (protein) IgG1 Kappa Light Chain (protein) Neuronal acetylcholine receptor subunit alpha-4 (protein) Neuronal acetylcholine receptor subunit beta-2 (protein)
Unique Ligands	NA, NAG, NCT, Y01
Unique branched monosaccharides	BMA, NAG

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6UR8 \| pdb_00006ur8	Download File View File

CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline

Alvarez, F.J.D., Mukherjee, S., Han, S., Ammirati, M., Kossiakoff, A.A.

(2020) Nat Commun 11: 1598-1598

Released	2020-04-29
Method	ELECTRON MICROSCOPY 3.71 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	Chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4 (protein) Neuronal acetylcholine receptor subunit beta-2 (protein)
Unique Ligands	BMA, NAG, QMR

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6USF \| pdb_00006usf	Download File View File

CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5

Alvarez, F.J.D., Mukherjee, S., Han, S., Ammirati, M., Kossiakoff, A.A.

(2020) Nat Commun 11: 1598-1598

Released	2020-04-29
Method	ELECTRON MICROSCOPY 3.87 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	Fab heavy chain (protein) Fab light chain (protein) Neuronal acetylcholine receptor subunit beta-2 (protein) chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4 (protein)
Unique Ligands	BMA, NAG, QMR
Unique branched monosaccharides	BMA, NAG

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8SSZ \| pdb_00008ssz	Download File View File

The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium

Kang, G., Hibbs, R.E.

(2024) Br J Pharmacol 181: 1973-1992

Released	2024-02-07
Method	ELECTRON MICROSCOPY 2.64 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	IgG1 Heavy Chain (protein) IgG1 Kappa Light Chain (protein) Neuronal acetylcholine receptor subunit alpha-4 (protein) Neuronal acetylcholine receptor subunit beta-2 (protein)
Unique Ligands	ACH, CA, NA, NAG, OCT
Unique branched monosaccharides	BMA, MAN, NAG

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8ST0 \| pdb_00008st0	Download File View File

The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine

Kang, G., Hibbs, R.E.

(2024) Br J Pharmacol 181: 1973-1992

Released	2024-02-07
Method	ELECTRON MICROSCOPY 2.4 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	IgG1 Heavy Chain (protein) IgG1 Kappa Light Chain (protein) Neuronal acetylcholine receptor subunit alpha-4 (protein) Neuronal acetylcholine receptor subunit beta-2 (protein)
Unique Ligands	ACH, NA, NAG, OCT
Unique branched monosaccharides	BMA, NAG

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8ST1 \| pdb_00008st1	Download File View File

The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium

Kang, G., Hibbs, R.E.

(2024) Br J Pharmacol 181: 1973-1992

Released	2024-02-07
Method	ELECTRON MICROSCOPY 3.41 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	IgG1 Heavy Chain (protein) IgG1 Kappa Light Chain (protein) Neuronal acetylcholine receptor subunit alpha-4 (protein) Neuronal acetylcholine receptor subunit beta-2 (protein)
Unique Ligands	ACH, CA, NA, NAG
Unique branched monosaccharides	BMA, NAG

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8ST2 \| pdb_00008st2	Download File View File

The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine

Kang, G., Hibbs, R.E.

(2024) Br J Pharmacol 181: 1973-1992

Released	2024-02-07
Method	ELECTRON MICROSCOPY 2.94 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	IgG1 Heavy Chain (protein) IgG1 Kappa Light Chain (protein) Neuronal acetylcholine receptor subunit alpha-4 (protein) Neuronal acetylcholine receptor subunit beta-2 (protein)
Unique Ligands	ACH, NA, NAG
Unique branched monosaccharides	BMA, NAG

Explore in 3D

8ST3 \| pdb_00008st3	Download File View File

The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium

Kang, G., Hibbs, R.E.

(2024) Br J Pharmacol 181: 1973-1992

Released	2024-02-07
Method	ELECTRON MICROSCOPY 2.93 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	IgG1 Heavy Chain (protein) IgG1 Kappa Light Chain (protein) Neuronal acetylcholine receptor subunit alpha-4 (protein) Neuronal acetylcholine receptor subunit beta-2 (protein)
Unique Ligands	ACH, CA, NA, NAG
Unique branched monosaccharides	BMA, NAG

Explore in 3D

8ST4 \| pdb_00008st4	Download File View File

The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine

Kang, G., Hibbs, R.E.

(2024) Br J Pharmacol 181: 1973-1992

Released	2024-02-07
Method	ELECTRON MICROSCOPY 2.35 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	IgG1 Heavy Chain (protein) IgG1 Kappa Light Chain (protein) Neuronal acetylcholine receptor subunit alpha-4 (protein) Neuronal acetylcholine receptor subunit beta-2 (protein)
Unique Ligands	ACH, NA, NAG
Unique branched monosaccharides	BMA, NAG

1 to 15 of 15 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

2K58 | pdb_00002k58

NMR structures of the first transmembrane domain of the neuronal acetylcholine receptor beta 2 subunit

2K59 | pdb_00002k59

NMR structures of the second transmembrane domain of the neuronal acetylcholine receptor beta 2 subunit

2KSR | pdb_00002ksr

NMR structures of TM domain of the n-Acetylcholine receptor b2 subunit

2LM2 | pdb_00002lm2

NMR structures of the transmembrane domains of the AChR b2 subunit

5KXI | pdb_00005kxi

X-ray structure of the human Alpha4Beta2 nicotinic receptor

6CNJ | pdb_00006cnj

Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor

6CNK | pdb_00006cnk

Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor

6UR8 | pdb_00006ur8

CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline

6USF | pdb_00006usf

CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5

8SSZ | pdb_00008ssz

The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium

8ST0 | pdb_00008st0

The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine

8ST1 | pdb_00008st1

The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium

8ST2 | pdb_00008st2

The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine

8ST3 | pdb_00008st3

The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium

8ST4 | pdb_00008st4

The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Membrane Protein Annotation

Symmetry Type

2K58 | pdb_00002k58

2K59 | pdb_00002k59

2KSR | pdb_00002ksr

2LM2 | pdb_00002lm2

5KXI | pdb_00005kxi

6CNJ | pdb_00006cnj

6CNK | pdb_00006cnk

6UR8 | pdb_00006ur8

6USF | pdb_00006usf

8SSZ | pdb_00008ssz

8ST0 | pdb_00008st0

8ST1 | pdb_00008st1

8ST2 | pdb_00008st2

8ST3 | pdb_00008st3

8ST4 | pdb_00008st4