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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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Search Summary

This query matches 56 Structures.

Refinements

Structure Determination Methodology

experimental (56)

Scientific Name of Source Organism

	Homo sapiens (30)
	Bos taurus (7)
	Mus musculus (4)
	Caenorhabditis elegans (3)
	Plasmodium falciparum (2)
	Strongylocentrotus purpuratus (2)
	Bacillus subtilis (1)
	Bdellovibrio bacteriovorus HD100 (1)
	Escherichia coli (1)
	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (1)

More...

Taxonomy

	Eukaryota (46)
	Bacteria (9)
	other sequences (1)

Experimental Method

	ELECTRON MICROSCOPY (29)
	X-RAY DIFFRACTION (26)
	NEUTRON DIFFRACTION (1)
	SOLUTION NMR (1)

Polymer Entity Type

	Protein (55)
	DNA (2)

Refinement Resolution (Å)

	1.0 - 1.5 (2)
	1.5 - 2.0 (5)
	2.0 - 2.5 (10)
	2.5 - 3.0 (13)
	3.0 - 3.5 (19)
	3.5 - 4.0 (6)

Release Date

	1995 - 1999 (1)
	2000 - 2004 (3)
	2005 - 2009 (6)
	2010 - 2014 (6)
	2015 - 2019 (10)
	2020 - 2024 (30)

Enzyme Classification Name

	Hydrolases (11)
	Transferases (10)

Membrane Protein Annotation

	PDBTM (22)
	mpstruc (22)
	MemProtMD (19)
	OPM (11)

Symmetry Type

	Asymmetric (33)
	Cyclic (26)
	Dihedral (4)

SCOP Classification

	All beta proteins (16)
	All alpha proteins (4)
	Artifacts (5)
	Alpha and beta proteins (a+b) (2)

AllSelected

1 to 25 of 56 Structures

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1BE4 \| pdb_00001be4	Download File View File

NUCLEOSIDE DIPHOSPHATE KINASE ISOFORM B FROM BOVINE RETINA

Ladner, J.E., Abdulaev, N.G., Kakuev, D.L., Karaschuk, G.N., Tordova, M., Eisenstein, E., Fujiwara, J.H., Ridge, K.D., Gilliland, G.L.

(1998) Biochemistry 37: 13958-13967

Released	1999-01-13
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Bos taurus
Macromolecule	NUCLEOSIDE DIPHOSPHATE TRANSFERASE (protein)
Unique Ligands	PCG

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1MC0 \| pdb_00001mc0	Download File View File

Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains

Martinez, S., Wu, A., Glavas, N., Tang, X., Turley, S., Hol, W., Beavo, J.

(2002) Proc Natl Acad Sci U S A 99: 13260-13265

Released	2002-10-02
Method	X-RAY DIFFRACTION 2.86 Å
Organisms	Mus musculus
Macromolecule	3',5'-cyclic nucleotide phosphodiesterase 2A (protein)
Unique Ligands	PCG

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1Q3E \| pdb_00001q3e	Download File View File

HCN2J 443-645 in the presence of cGMP

Zagotta, W.N., Olivier, N.B., Black, K.D., Young, E.C., Olson, R., Gouaux, J.E.

(2003) Nature 425: 200-205

Released	2003-09-09
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (protein)
Unique Ligands	PCG

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1RL3 \| pdb_00001rl3	Download File View File

Crystal structure of cAMP-free R1a subunit of PKA

Wu, J., Brown, S., Xuong, N.-H., Taylor, S.S.

(2004) Structure 12: 1057-1065

Released	2004-07-06
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Bos taurus
Macromolecule	cAMP-dependent protein kinase type I-alpha regulatory chain (protein)
Unique Ligands	GOL, PCG

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2GX5 \| pdb_00002gx5	Download File View File

N-terminal GAF domain of transcriptional pleiotropic repressor CodY

Wilkinson, A.J., Levdikov, V.M., Blagova, E.V.

(2006) J Biological Chem 281: 11366-11373

Released	2007-04-17
Method	X-RAY DIFFRACTION 1.74 Å
Organisms	Bacillus subtilis
Macromolecule	GTP-sensing transcriptional pleiotropic repressor codY (protein)
Unique Ligands	GOL, P6G, PCG, PG4, PGE, SO4

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2Q0A \| pdb_00002q0a	Download File View File

Structure and rearrangements in the carboxy-terminal region of SpIH channels

Flynn, G.E., Black, K.D., Islas, L.D., Sankaran, B., Zagotta, W.N.

(2007) Structure 15: 671-682

Released	2007-06-19
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Mus musculus
Macromolecule	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (protein)
Unique Ligands	PCG

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3CL1 \| pdb_00003cl1	Download File View File

M. loti cyclic-nucleotide binding domain, cyclic-GMP bound

Clayton, G.M., Alteiri, S.L., Thomas, L.R., Morais-Cabral, J.H.

(2008) J Mol Biology 381: 655-669

Released	2008-08-05
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
Macromolecule	Mll3241 protein (protein)
Unique Ligands	CL, K, PCG, POL

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3DYL \| pdb_00003dyl	Download File View File

human phosphdiesterase 9 substrate complex (ES complex)

Liu, S., Mansour, M.N., Dillman, K., Perez, J., Danley, D., Menniti, F.

(2008) Proc Natl Acad Sci U S A 105: 13309-13314

Released	2008-09-16
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	human phosphodiesterase 9 (protein)
Unique Ligands	FMT, IBM, MG, MN, PCG

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3DYN \| pdb_00003dyn	Download File View File

human phosphodiestrase 9 in complex with cGMP (Zn inhibited)

Liu, S., Mansour, M.N., Dillman, K., Perez, J., Danley, D., Menniti, F.

(2008) Proc Natl Acad Sci U S A 105: 13309-13314

Released	2008-09-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (protein)
Unique Ligands	IBM, MG, PCG, ZN

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3DYQ \| pdb_00003dyq	Download File View File

human phosphodiestrase 9 (inhibited by omitting divalent cation) in complex with cGMP

Liu, S., Mansour, M.N., Dillman, K., Perez, J., Danley, D., Menniti, F.

(2008) Proc Natl Acad Sci U S A 105: 13309-13314

Released	2008-09-16
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (protein)
Unique Ligands	IBM, NA, PCG

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3OD0 \| pdb_00003od0	Download File View File

Crystal structure of cGMP bound cGMP-dependent protein kinase(92-227)

Kim, J.J., Huang, G., Kwon, T.K., Zwart, P., Headd, J., Kim, C.

(2011) PLoS One 6: e18413-e18413

Released	2011-05-11
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	PRKG1 protein (protein)
Unique Ligands	PCG

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4D7S \| pdb_00004d7s	Download File View File

Structure of the SthK Carboxy-Terminal Region in complex with cGMP

Kesters, D., Brams, M., Nys, M., Wijckmans, E., Spurny, R., Voets, T., Tytgat, J., Ulens, C.

(2015) PLoS One 10: 16369

Released	2015-02-11
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Spirochaeta thermophila DSM 6192
Macromolecule	STHK_CNBD_CGMP (protein)
Unique Ligands	PCG

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4KL1 \| pdb_00004kl1	Download File View File

HCN4 CNBD in complex with cGMP

Lolicato, M., Arrigoni, C., Zucca, S., Nardini, M., Bucchi, A., Schroeder, I., Simmons, K., Bolognesi, M., DiFrancesco, D., Schwede, F., Fishwick, C.W.G., Johnson, A.P.K., Thiel, G., Moroni, A.

(2014) Nat Chem Biol 10: 457-462

Released	2014-04-30
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (protein)
Unique Ligands	ACT, GOL, PCG

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4KU7 \| pdb_00004ku7	Download File View File

Structures of PKGI Reveal a cGMP-Selective Activation Mechanism

Huang, G.Y., Kim, J.J., Reger, A.S., Lorenz, R., Moon, E.W., Casteel, D.E., Sankaran, B., Herberg, F.W., Kim, C.

(2014) Structure 22: 116-124

Released	2014-01-15
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	cGMP-dependent protein kinase 1 (protein)
Unique Ligands	IOD, PCG

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4MUV \| pdb_00004muv	Download File View File

M. loti cyclic-nucleotide binding domain mutant displaying inverted ligand selectivity, cyclic-GMP bound

Fonseca, F., Pessoa, J., Morais-Cabral, J.H.

(2014) J Gen Physiol 144: 41-54

Released	2014-06-25
Method	X-RAY DIFFRACTION 1.25 Å
Organisms	Mesorhizobium japonicum MAFF 303099
Macromolecule	Cyclic nucleotide-gated potassium channel mll3241 (protein)
Unique Ligands	NA, PCG

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4N9I \| pdb_00004n9i	Download File View File

Crystal Structure of Transcription regulation protein CRP complexed with cGMP

Lee, B.-J., Seok, S.-H., Im, H., Yoon, H.-J.

(2014) Acta Crystallogr D Biol Crystallogr 70: 1726-1742

Released	2014-07-09
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Escherichia coli
Macromolecule	Catabolite gene activator (protein)
Unique Ligands	PCG

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4OFG \| pdb_00004ofg	Download File View File

Co-crystal structure of carboxy cGMP binding domain of Plasmodium falciparum PKG with cGMP

Kim, J.J., Sanabria figueroa, E., Kim, C.

(2015) PLoS Pathog 11: e1004639-e1004639

Released	2015-01-21
Method	X-RAY DIFFRACTION 2 Å
Organisms	Plasmodium falciparum
Macromolecule	CGMP-dependent protein kinase (protein)
Unique Ligands	EOH, N2P, PCG, SO4

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4QXK \| pdb_00004qxk	Download File View File

Joint X-ray/neutron structure of PKGIbeta in complex with cGMP

Kim, C., Gerlits, O., Kovalevsky, A., Huang, G.Y.

(2014) Biochemistry 53: 6725-6727

Released	2014-11-12
Method	X-RAY DIFFRACTION NEUTRON DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	cGMP-dependent protein kinase 1 (protein)
Unique Ligands	NA, PCG

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4Z07 \| pdb_00004z07	Download File View File

Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP

Kim, J.J., Reger, A.S., Arold, S.T., Kim, C.

(2016) Structure 24: 710-720

Released	2016-04-13
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	cGMP-dependent protein kinase 1 (protein)
Unique Ligands	IPA, PCG, SO4

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5C8W \| pdb_00005c8w	Download File View File

PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cGMP

Campbell, J.C., Reger, A.S., Huang, G.Y., Sankaran, B., Kim, J.J., Kim, C.W.

(2016) J Biological Chem 291: 5623-5633

Released	2016-01-20
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	cGMP-dependent protein kinase 2 (protein)
Unique Ligands	MLA, NA, PCG

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5E16 \| pdb_00005e16	Download File View File

Co-crystal structure of the N-termial cGMP binding domain of Plasmodium falciparum PKG with cGMP

El Bakkouri, M., Walker, J.R., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Structural Genomics Consortium (SGC)

(2019) Proc Natl Acad Sci U S A 116: 14164-14173

Released	2015-11-04
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Plasmodium falciparum
Macromolecule	CGMP-dependent protein kinase (protein)
Unique Ligands	PCG

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5H3O \| pdb_00005h3o	Download File View File

Structure of a eukaryotic cyclic nucleotide-gated channel

Li, M., Zhou, X., Wang, S., Michailidis, I., Gong, Y., Su, D., Li, H., Li, X., Yang, J.

(2017) Nature 542: 60-65

Released	2017-01-25
Method	ELECTRON MICROSCOPY 3.5 Å
Organisms	Caenorhabditis elegans
Macromolecule	Cyclic nucleotide-gated cation channel (protein)
Unique Ligands	NA, PCG

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5H5O \| pdb_00005h5o	Download File View File

A cyclic-GMP-dependent signalling pathway regulates bacterial phytopathogenesis

Chin, K.H., Chou, S.-H.

(2013) EMBO J 32: 2430-2438

Released	2017-05-24
Method	X-RAY DIFFRACTION 2.122 Å
Organisms	Xanthomonas campestris pv. campestris str. B100
Macromolecule	Diguanylate cyclase (protein)
Unique Ligands	PCG

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5KJZ \| pdb_00005kjz	Download File View File

Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cGMP

Lorenz, R., Moon, E., Kim, J.J., Huang, G.Y., Kim, C., Herberg, F.W.

(2017) Biochem J 474: 2389-2403

Released	2017-06-28
Method	X-RAY DIFFRACTION 1.347 Å
Organisms	Homo sapiens
Macromolecule	cAMP-dependent protein kinase type I-alpha regulatory subunit (protein)
Unique Ligands	GOL, PCG

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6CJT \| pdb_00006cjt	Download File View File

Structure of the SthK cyclic nucleotide-gated potassium channel in complex with cGMP

Nimigean, C.M., Rheinberger, J.

(2018) Elife 7:

Released	2018-08-01
Method	ELECTRON MICROSCOPY 3.46 Å
Organisms	Spirochaeta thermophila DSM 6578
Macromolecule	SthK cyclic nucleotide-gated potassium channel (protein)
Unique Ligands	PCG, PGW

1 to 25 of 56 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1BE4 | pdb_00001be4

1MC0 | pdb_00001mc0

1Q3E | pdb_00001q3e

1RL3 | pdb_00001rl3

2GX5 | pdb_00002gx5

2Q0A | pdb_00002q0a

3CL1 | pdb_00003cl1

3DYL | pdb_00003dyl

3DYN | pdb_00003dyn

3DYQ | pdb_00003dyq

3OD0 | pdb_00003od0

4D7S | pdb_00004d7s

4KL1 | pdb_00004kl1

4KU7 | pdb_00004ku7

4MUV | pdb_00004muv

4N9I | pdb_00004n9i

4OFG | pdb_00004ofg

4QXK | pdb_00004qxk

4Z07 | pdb_00004z07

5C8W | pdb_00005c8w

5E16 | pdb_00005e16

5H3O | pdb_00005h3o

5H5O | pdb_00005h5o

5KJZ | pdb_00005kjz

6CJT | pdb_00006cjt