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234,785 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Otake, K."

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This query matches 8 Structures.

Refinements

Structure Determination Methodology

experimental (8)

Scientific Name of Source Organism

	Homo sapiens (5)
	Pseudomonas aeruginosa PAO1 (3)

Taxonomy

	Eukaryota (5)
	Bacteria (3)

Experimental Method

X-RAY DIFFRACTION (8)

Polymer Entity Type

Protein (8)

Refinement Resolution (Å)

	1.0 - 1.5 (3)
	1.5 - 2.0 (3)
	2.0 - 2.5 (2)

Release Date

2020 - 2024 (8)

Enzyme Classification Name

Hydrolases (3)

Symmetry Type

Asymmetric (8)

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1 to 8 of 8 Structures

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Explore in 3D

7DEL \| pdb_00007del	Download File View File

Crystal structure of P.aeruginosa LpxC in complex with inhibitor

Mima, M., Ushiyama, F., Tanaka-Yamamoto, N.

(2020) Bioorg Med Chem 30: 115964-115964

Released	2021-01-13
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Pseudomonas aeruginosa PAO1
Macromolecule	UDP-3-O-acyl-N-acetylglucosamine deacetylase (protein)
Unique Ligands	H4L, ZN

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7DEM \| pdb_00007dem	Download File View File

Crystal structure of P.aeruginosa LpxC in complex with inhibitor

Mima, M., Ushiyama, F., Matsuda, Y.

(2020) Bioorg Med Chem 30: 115964-115964

Released	2021-01-13
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Pseudomonas aeruginosa PAO1
Macromolecule	UDP-3-O-acyl-N-acetylglucosamine deacetylase (protein)
Unique Ligands	H4O, ZN

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7DEN \| pdb_00007den	Download File View File

Crystal structure of P.aeruginosa LpxC in complex with inhibitor

Mima, M., Ushiyama, F., Takashima, H.

(2020) Bioorg Med Chem 30: 115964-115964

Released	2021-01-13
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Pseudomonas aeruginosa PAO1
Macromolecule	UDP-3-O-acyl-N-acetylglucosamine deacetylase (protein)
Unique Ligands	H4R, ZN

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8IVG \| pdb_00008ivg	Download File View File

Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease

Otake, K., Ubukata, M., Nagahashi, N., Ogawa, N., Hantani, Y., Hantani, R., Adachi, T., Nomura, A., Yamaguchi, K., Maekawa, M., Mamada, H., Motomura, T., Sato, M., Harada, K.

(2023) ACS Med Chem Lett 14: 658-665

Released	2023-06-14
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Kelch-like ECH-associated protein 1 (protein)
Unique Ligands	DTT, SGO, SO4

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8IVR \| pdb_00008ivr	Download File View File

Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease

Nomura, A., Yamaguchi, K., Adachi, T.

(2023) ACS Med Chem Lett 14: 658-665

Released	2023-06-14
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Kelch-like ECH-associated protein 1 (protein)
Unique Ligands	SIU, SO4

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8IXS \| pdb_00008ixs	Download File View File

Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease

Nomura, A., Yamaguchi, K., Adachi, T.

(2023) ACS Med Chem Lett 14: 658-665

Released	2023-06-14
Method	X-RAY DIFFRACTION 1.48 Å
Organisms	Homo sapiens
Macromolecule	Kelch-like ECH-associated protein 1 (protein)
Unique Ligands	SO4, T6I

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8XGK \| pdb_00008xgk	Download File View File

Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Ihhibitors

Otake, K., Hara, Y., Ubukata, M., Inoue, M., Nagahashi, N., Motoda, D., Ogawa, N., Hantani, Y., Hantani, R., Adachi, T., Nomura, A., Yamaguchi, K., Maekawa, M., Mamada, H., Motomura, T., Sato, M., Harada, K.

(2024) J Med Chem 67: 3741-3763

Released	2024-05-22
Method	X-RAY DIFFRACTION 1.32 Å
Organisms	Homo sapiens
Macromolecule	Kelch-like ECH-associated protein 1 (protein)
Unique Ligands	A1LVB, ACT, SO4

Explore in 3D

8XGV \| pdb_00008xgv	Download File View File

Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction (PPI) Inhibitors

(2024) J Med Chem 67: 3741-3763

Released	2024-05-22
Method	X-RAY DIFFRACTION 1.42 Å
Organisms	Homo sapiens
Macromolecule	Kelch-like ECH-associated protein 1 (protein)
Unique Ligands	A1LVC, ACT, SO4

1 to 8 of 8 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

7DEL | pdb_00007del

Crystal structure of P.aeruginosa LpxC in complex with inhibitor

7DEM | pdb_00007dem

Crystal structure of P.aeruginosa LpxC in complex with inhibitor

7DEN | pdb_00007den

Crystal structure of P.aeruginosa LpxC in complex with inhibitor

8IVG | pdb_00008ivg

Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease

8IVR | pdb_00008ivr

Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease

8IXS | pdb_00008ixs

Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease

8XGK | pdb_00008xgk

Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Ihhibitors

8XGV | pdb_00008xgv

Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction (PPI) Inhibitors

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

7DEL | pdb_00007del

7DEM | pdb_00007dem

7DEN | pdb_00007den

8IVG | pdb_00008ivg

8IVR | pdb_00008ivr

8IXS | pdb_00008ixs

8XGK | pdb_00008xgk

8XGV | pdb_00008xgv