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234,785 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Luth, M.R."

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Search Summary

This query matches 12 Structures.

Refinements

Structure Determination Methodology

experimental (12)

Scientific Name of Source Organism

	Homo sapiens (5)
	Naegleria fowleri (4)
	Plasmodium falciparum 3D7 (3)

Taxonomy

Eukaryota (12)

Experimental Method

X-RAY DIFFRACTION (12)

Polymer Entity Type

Protein (12)

Refinement Resolution (Å)

	1.5 - 2.0 (5)
	2.0 - 2.5 (5)
	2.5 - 3.0 (2)

Release Date

	2015 - 2019 (4)
	2020 - 2024 (8)

Enzyme Classification Name

Ligases (8)

Symmetry Type

	Cyclic (8)
	Asymmetric (4)

SCOP Classification

	All alpha proteins (4)
	Artifacts (4)

AllSelected

1 to 12 of 12 Structures

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6AY4 \| pdb_00006ay4	Download File View File

Naegleria fowleri CYP51-fluconazole complex

Debnath, A., Calvet, C.M., Jennings, G., Zhou, W., Aksenov, A., Luth, M., Abagyan, R., Nes, W.D., McKerrow, J.H., Podust, L.M.

(2017) PLoS Negl Trop Dis 11: e0006104-e0006104

Released	2017-11-22
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Naegleria fowleri
Macromolecule	CYP51, sterol 14alpha-demethylase (protein)
Unique Ligands	EDO, HEM, TPF

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6AY6 \| pdb_00006ay6	Download File View File

Naegleria fowleri CYP51-voriconazole complex

Debnath, A., Calvet, C.M., Jennings, G., Zhou, W., Aksenov, A., Luth, M., Abagyan, R., Nes, W.D., McKerrow, J.H., Podust, L.M.

(2017) PLoS Negl Trop Dis 11: e0006104-e0006104

Released	2017-11-22
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Naegleria fowleri
Macromolecule	CYP51, sterol 14alpha-demethylase (protein)
Unique Ligands	HEM, VOR

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6AYB \| pdb_00006ayb	Download File View File

Naegleria fowleri CYP51-ketoconazole complex

Debnath, A., Calvet, C.M., Jennings, G., Zhou, W., Aksenov, A., Luth, M., Abagyan, R., Nes, W.D., McKerrow, J.H., Podust, L.M.

(2017) PLoS Negl Trop Dis 11: e0006104-e0006104

Released	2017-11-22
Method	X-RAY DIFFRACTION 1.87 Å
Organisms	Naegleria fowleri
Macromolecule	CYP51, sterol 14alpha-demethylase (protein)
Unique Ligands	CA, EDO, HEM, KKK

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6AYC \| pdb_00006ayc	Download File View File

Naegleria fowleri CYP51-itraconazole complex

Debnath, A., Calvet, C.M., Jennings, G., Zhou, W., Aksenov, A., Luth, M., Abagyan, R., Nes, W.D., McKerrow, J.H., Podust, L.M.

(2017) PLoS Negl Trop Dis 11: e0006104-e0006104

Released	2017-11-22
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Naegleria fowleri
Macromolecule	Protein CYP51 (protein)
Unique Ligands	1YN, HEM

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7ROR \| pdb_00007ror	Download File View File

Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP

Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2022) Science 376: 1074-1079

Released	2022-06-08
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Tyrosine--tRNA ligase (protein)
Unique Ligands	69X, CL, MG, MLI

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7ROS \| pdb_00007ros	Download File View File

Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML901-Tyr

Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2022) Science 376: 1074-1079

Released	2022-06-08
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Tyrosine--tRNA ligase (protein)
Unique Ligands	66I, CL, MG

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7ROT \| pdb_00007rot	Download File View File

Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr

Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2022) Science 376: 1074-1079

Released	2022-06-08
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Tyrosine--tRNA ligase (protein)
Unique Ligands	66I, CL, MG

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7ROU \| pdb_00007rou	Download File View File

Structure of human tyrosyl tRNA synthetase in complex with ML901-Tyr

Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2022) Science 376: 1074-1079

Released	2022-06-08
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine--tRNA ligase, cytoplasmic (protein)
Unique Ligands	66I, SO4

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8H53 \| pdb_00008h53	Download File View File

Human asparaginyl-tRNA synthetase in complex with asparagine-AMP

Park, J.S., Han, B.W.

(2024) Nat Commun 15: 937-937

Released	2023-10-25
Method	X-RAY DIFFRACTION 2.16 Å
Organisms	Homo sapiens
Macromolecule	Asparagine--tRNA ligase, cytoplasmic (protein)
Unique Ligands	2PN, 4AD, GOL, MG

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8TC7 \| pdb_00008tc7	Download File View File

Human asparaginyl-tRNA synthetase, apo form

Dogovski, C., Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2024) Nat Commun 15: 937-937

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Asparagine--tRNA ligase, cytoplasmic (protein)
Unique Ligands	CL, GOL

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8TC8 \| pdb_00008tc8	Download File View File

Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate

Dogovski, C., Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2024) Nat Commun 15: 937-937

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Asparagine--tRNA ligase, cytoplasmic (protein)
Unique Ligands	GOL, NA, NSS