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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Lenardo, M.J."

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Search Summary

This query matches 153 Structures.

Refinements

Structure Determination Methodology

experimental (153)

Scientific Name of Source Organism

	Homo sapiens (77)
	Sus scrofa (28)
	Mus musculus (11)
	synthetic construct (8)
	Xenopus laevis (6)
	Escherichia coli BL21(DE3) (5)
	Escherichia coli (4)
	Saccharomyces cerevisiae (4)
	Severe acute respiratory syndrome coronavirus 2 (4)
	Gallus gallus (3)

More...

Taxonomy

	Eukaryota (116)
	Bacteria (28)
	other sequences (8)
	Riboviria (6)
	unclassified sequences (3)
	Adnaviria (2)
	Archaea (1)
	Duplodnaviria (1)
	Varidnaviria (1)

Experimental Method

	ELECTRON MICROSCOPY (76)
	X-RAY DIFFRACTION (74)
	SOLUTION NMR (3)

Polymer Entity Type

	Protein (153)
	DNA (11)
	RNA (3)

Refinement Resolution (Å)

	1.0 - 1.5 (2)
	1.5 - 2.0 (20)
	2.0 - 2.5 (27)
	2.5 - 3.0 (34)
	3.0 - 3.5 (20)
	3.5 - 4.0 (26)
	4.0 - 4.5 (13)
	> 4.5 (8)

Release Date

	1995 - 1999 (2)
	2000 - 2004 (2)
	2005 - 2009 (4)
	2010 - 2014 (18)
	2015 - 2019 (39)
	2020 - 2024 (84)
	2025 - 2029 (4)

Enzyme Classification Name

	Translocases (30)
	Transferases (27)
	Hydrolases (26)
	Oxidoreductases (2)
	Isomerases (2)
	Lyases (2)

Membrane Protein Annotation

	PDBTM (8)
	mpstruc (7)
	OPM (8)
	MemProtMD (3)

Symmetry Type

	Asymmetric (106)
	Cyclic (23)
	Helical (22)
	Dihedral (5)

SCOP Classification

	Alpha and beta proteins (a/b) (13)
	Alpha and beta proteins (a+b) (10)
	All alpha proteins (10)
	All beta proteins (2)
	Artifacts (6)
	Membrane and cell surface proteins and peptides (2)

AllSelected

1 to 25 of 153 Structures

Page 1 of 7

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1A6R \| pdb_00001a6r	Download File View File

GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A

Joshua-Tor, L., Zheng, W., Johnston, S.A.

(1998) Cell 93: 103-109

Released	1998-10-21
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	GAL6 (protein)
Unique Ligands	SO4

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1CB5 \| pdb_00001cb5	Download File View File

HUMAN BLEOMYCIN HYDROLASE.

O'Farrell, P.A., Gonzalez, F., Zheng, W., Johnston, S.A., Joshua-Tor, L.

(1999) Structure 7: 619-627

Released	2000-03-01
Method	X-RAY DIFFRACTION 2.59 Å
Organisms	Homo sapiens
Macromolecule	BLEOMYCIN HYDROLASE (protein)

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2CB5 \| pdb_00002cb5	Download File View File

HUMAN BLEOMYCIN HYDROLASE, C73S/DELE455 MUTANT

O'Farrell, P.A., Gonzalez, F., Zheng, W., Johnston, S.A., Joshua-Tor, L.

(1999) Structure 7: 619-627

Released	2000-03-06
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (BLEOMYCIN HYDROLASE) (protein)

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2ICJ \| pdb_00002icj	Download File View File

The crystal structure of human isopentenyl diphophate isomerase

Zheng, W., Bartlam, M., Rao, Z.

(2007) J Mol Biology 366: 1447-1458

Released	2007-03-20
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Isopentenyl-diphosphate delta isomerase (protein)
Unique Ligands	MG, SO4

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2ICK \| pdb_00002ick	Download File View File

Human isopentenyl diphophate isomerase complexed with substrate analog

Zheng, W., Bartlam, M., Rao, Z.

(2007) J Mol Biology 366: 1447-1458

Released	2007-03-20
Method	X-RAY DIFFRACTION 1.93 Å
Organisms	Homo sapiens
Macromolecule	Isopentenyl-diphosphate delta isomerase (protein)
Unique Ligands	DMA, MN

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3D4B \| pdb_00003d4b	Download File View File

Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+

Hawse, W.F., Hoff, K.G., Fatkins, D., Daines, A., Zubkova, O.V., Schramm, V.L., Zheng, W., Wolberger, C.

(2008) Structure 16: 1368-1377

Released	2008-09-30
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Thermotoga maritima
Macromolecule	Acetyl P53 peptide (protein) NAD-dependent deacetylase (protein)
Unique Ligands	DZD, ZN

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3D81 \| pdb_00003d81	Download File View File

Sir2-S-alkylamidate complex crystal structure

Hawse, W.F., Hoff, K.G., Fatkins, D., Daines, A., Zubkova, O.V., Schramm, V.L., Zheng, W., Wolberger, C.

(2008) Structure 16: 1368-1377

Released	2008-09-30
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Thermotoga maritima
Macromolecule	NAD-dependent deacetylase (protein) S-alkylamidate intermediate (protein)
Unique Ligands	ZN

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3GCB \| pdb_00003gcb	Download File View File

GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A/DELTAK454

Joshua-Tor, L., Zheng, W., Johnston, S.A.

(1998) Cell 93: 103-109

Released	1998-10-21
Method	X-RAY DIFFRACTION 1.87 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	GAL6 (protein)
Unique Ligands	GOL, SO4

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3L1N \| pdb_00003l1n	Download File View File

Crystal structure of Mp1p ligand binding domain 2 complexd with palmitic acid

Liao, S., Tung, E.T., Zheng, W., Chong, K., Xu, Y., Bartlam, M., Rao, Z., Yuen, K.Y.

(2010) J Biological Chem 285: 9211-9220

Released	2010-01-05
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Talaromyces marneffei
Macromolecule	Cell wall antigen (protein)
Unique Ligands	PLM

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3O4X \| pdb_00003o4x	Download File View File

Crystal structure of complex between amino and carboxy terminal fragments of mDia1

Eck, M.J., Nezami, A., Toms, A.V.

(2010) PLoS One 5: e12992-e12992

Released	2010-10-13
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Mus musculus
Macromolecule	Protein diaphanous homolog 1 (protein)

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3OKQ \| pdb_00003okq	Download File View File

Crystal structure of a core domain of yeast actin nucleation cofactor Bud6

Tu, D., Eck, M.J.

(2012) Proc Natl Acad Sci U S A 109: E3424-E3433

Released	2011-09-14
Method	X-RAY DIFFRACTION 2.044 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Bud site selection protein 6 (protein)

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3ONX \| pdb_00003onx	Download File View File

Crystal structure of a domain of a protein involved in formation of actin cytoskeleton

Tu, D., Eck, M.J.

(2012) Proc Natl Acad Sci U S A 109: E3424-E3433

Released	2011-10-12
Method	X-RAY DIFFRACTION 2.904 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Bud site selection protein 6 (protein)

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3R7G \| pdb_00003r7g	Download File View File

Crystal structure of Spire KIND domain in complex with the tail of FMN2

Kreutz, B., Vizcarra, C.L., Rodal, A.A., Toms, A.V., Lu, J., Quinlan, M.E., Eck, M.J.

(2011) Proc Natl Acad Sci U S A

Released	2011-07-06
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Formin-2 (protein) Protein spire homolog 1 (protein)

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3RBW \| pdb_00003rbw	Download File View File

Crystal structure of Spire KIND domain

Vizcarra, C.L., Kreutz, B., Rodal, A.A., Toms, A.V., Lu, J., Zheng, W., Quinlan, M.E., Eck, M.J.

(2011) Proc Natl Acad Sci U S A

Released	2011-07-06
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Homo sapiens
Macromolecule	Protein spire homolog 1 (protein)

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4DQM \| pdb_00004dqm	Download File View File

Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity

Wang, S., Wang, Z., Lin, S., Zheng, W., Wang, R., Jin, S., Chen, J., Jin, L., Li, Y.

(2012) Biochem J 446: 79-87

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Homo sapiens
Macromolecule	Nuclear receptor coactivator 1 (protein) Retinoic acid receptor alpha (protein)
Unique Ligands	LUF

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4EWC \| pdb_00004ewc	Download File View File

Crystal Structure of the Infectious Salmon Anemia Virus Nucleoprotein

Zheng, W., Tao, Y.J.

(2013) PLoS Pathog 9: e1003624-e1003624

Released	2013-05-08
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Isavirus salaris
Macromolecule	Putative nucleoprotein (protein)

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4FGY \| pdb_00004fgy	Download File View File

Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity

Wang, R., Li, Y.

(2013) Diabetologia 56: 401-411

Released	2013-03-20
Method	X-RAY DIFFRACTION 2.84 Å
Organisms	Homo sapiens
Macromolecule	Nuclear receptor coactivator 1 (protein) Peroxisome proliferator-activated receptor gamma (protein)
Unique Ligands	0W3

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4FIA \| pdb_00004fia	Download File View File

Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound

Stout, C.D., Pikuleva, I.A., Mast, N.

(2013) J Biological Chem 288: 4613-4624

Released	2013-01-09
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Cholesterol 24-hydroxylase (protein)
Unique Ligands	0U9, 198, GOL, HEM

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4FMU \| pdb_00004fmu	Download File View File

Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF

Dong, A., Zeng, H., Ibanez, G., Zheng, W., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)

(2012) J Am Chem Soc 134: 18004-18014

Released	2012-09-05
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase SETD2 (protein)
Unique Ligands	0UM, UNX, ZN

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4H12 \| pdb_00004h12	Download File View File

The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine

Amaya, M.F., Dong, A., Zeng, H., Mackenzie, F., Bunnage, M., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Wu, H., Structural Genomics Consortium (SGC)

(2012) J Am Chem Soc 134: 18004-18014

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase SETD2 (protein)
Unique Ligands	CL, SAH, ZN

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4HC4 \| pdb_00004hc4	Download File View File

Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae)

Dong, A., Zeng, H., He, H., El Bakkouri, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)

(2016) Biochem J 473: 3049-3063

Released	2012-10-17
Method	X-RAY DIFFRACTION 1.97 Å
Organisms	Homo sapiens
Macromolecule	Protein arginine N-methyltransferase 6 (protein)
Unique Ligands	EDO, GOL, SAH

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4I51 \| pdb_00004i51	Download File View File

Methyltransferase domain of HUMAN EUCHROMATIC HISTONE METHYLTRANSFERASE 1, mutant Y1211A

Dong, A., Zeng, H., Walker, J.R., Islam, K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Lou, M., Min, J., Wu, H., Structural Genomics Consortium (SGC)

(2013) Proc Natl Acad Sci U S A 110: 16778-16783

Released	2012-12-19
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	H3K9 NE-ALLYL PEPTIDE (protein) Histone-lysine N-methyltransferase EHMT1 (protein) UNKNOWN PEPTIDE (protein)
Unique Ligands	GOL, SAH, UNX, ZN

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4IKP \| pdb_00004ikp	Download File View File

Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin

Dong, A., Dombrovski, L., He, H., Ibanez, G., Wernimont, A., Zheng, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)

(2019) Elife 8:

Released	2013-02-13
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Histone-arginine methyltransferase CARM1 (protein)
Unique Ligands	4IK, GOL, UNX