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234,785 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Hinck, C.S."

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Search Summary

This query matches 41 Structures.

Refinements

Structure Determination Methodology

experimental (41)

Scientific Name of Source Organism

	Homo sapiens (27)
	Danio rerio (5)
	synthetic construct (4)
	Mus musculus (2)
	Rattus norvegicus (2)
	Archaeoglobus fulgidus (1)
	Bacillus thermoproteolyticus (1)
	Bos taurus (1)
	Gallus gallus (1)
	Heligmosomoides polygyrus (1)

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Taxonomy

	Eukaryota (37)
	other sequences (4)
	Archaea (1)
	Bacteria (1)

Experimental Method

	X-RAY DIFFRACTION (27)
	ELECTRON CRYSTALLOGRAPHY (8)
	ELECTRON MICROSCOPY (3)
	SOLUTION NMR (3)

Polymer Entity Type

Protein (41)

Refinement Resolution (Å)

	1.0 - 1.5 (2)
	1.5 - 2.0 (10)
	2.0 - 2.5 (14)
	2.5 - 3.0 (7)
	3.0 - 3.5 (3)
	3.5 - 4.0 (1)
	4.0 - 4.5 (1)

Release Date

	2000 - 2004 (1)
	2005 - 2009 (2)
	2010 - 2014 (1)
	2015 - 2019 (15)
	2020 - 2024 (5)
	2025 - 2029 (17)

Enzyme Classification Name

	Transferases (11)
	Hydrolases (6)

Symmetry Type

	Asymmetric (24)
	Cyclic (17)

SCOP Classification

	Small proteins (8)
	All beta proteins (3)
	Alpha and beta proteins (a+b) (2)
	Alpha and beta proteins (a/b) (1)

AllSelected

1 to 25 of 41 Structures

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1KTZ \| pdb_00001ktz	Download File View File

Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3

Hart, P.J., Deep, S., Taylor, A.B., Shu, Z., Hinck, C.S., Hinck, A.P.

(2002) Nat Struct Biol 9: 203-208

Released	2002-02-27
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	TGF-beta Type II Receptor (protein) TRANSFORMING GROWTH FACTOR BETA 3 (protein)

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2JQE \| pdb_00002jqe	Download File View File

Soution Structure of Af54 M-domain

Ilangovan, U., Hinck, A.P., Zwieb, C.

(2008) J Biomol NMR 41: 241-248

Released	2008-06-10
Method	SOLUTION NMR
Organisms	Archaeoglobus fulgidus
Macromolecule	Signal recognition 54 kDa protein (protein)

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2L5S \| pdb_00002l5s	Download File View File

Solution structure of the extracellular domain of the TGF-beta type I receptor

Zuniga, J.E., Ilangovan, U., Pardeep, M., Hinck, C., Huang, T.

(2011) J Mol Biology 412: 601-618

Released	2011-10-26
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	TGF-beta receptor type-1 (protein)

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2PJY \| pdb_00002pjy	Download File View File

Structural basis for cooperative assembly of the TGF-beta signaling complex

Groppe, J., Zubieta, C.

(2008) Mol Cell 29: 157-168

Released	2008-02-05
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	TGF-beta receptor type-1 (protein) TGF-beta receptor type-2 (protein) Transforming growth factor beta-3 (protein)

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5K7N \| pdb_00005k7n	Download File View File

MicroED structure of tau VQIVYK peptide at 1.1 A resolution

de la Cruz, M.J., Hattne, J., Shi, D., Seidler, P., Rodriguez, J., Reyes, F.E., Sawaya, M.R., Cascio, D., Eisenberg, D., Gonen, T.

(2017) Nat Methods 14: 399-402

Released	2017-04-05
Method	ELECTRON CRYSTALLOGRAPHY 1.1 Å
Organisms	Homo sapiens
Macromolecule	VQIVYK (protein)

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5K7O \| pdb_00005k7o	Download File View File

MicroED structure of lysozyme at 1.8 A resolution

de la Cruz, M.J., Hattne, J., Shi, D., Seidler, P., Rodriguez, J., Reyes, F.E., Sawaya, M.R., Cascio, D., Eisenberg, D., Gonen, T.

(2017) Nat Methods 14: 399-402

Released	2017-04-05
Method	ELECTRON CRYSTALLOGRAPHY 1.8 Å
Organisms	Gallus gallus
Macromolecule	Lysozyme C (protein)
Unique Ligands	CL, NA

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5K7P \| pdb_00005k7p	Download File View File

MicroED structure of xylanase at 2.3 A resolution

de la Cruz, M.J., Hattne, J., Shi, D., Seidler, P., Rodriguez, J., Reyes, F.E., Sawaya, M.R., Cascio, D., Eisenberg, D., Gonen, T.

(2017) Nat Methods 14: 399-402

Released	2017-04-05
Method	ELECTRON CRYSTALLOGRAPHY 2.3 Å
Organisms	Trichoderma reesei
Macromolecule	Endo-1,4-beta-xylanase 2 (protein)
Unique Ligands	IOD

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5K7Q \| pdb_00005k7q	Download File View File

MicroED structure of thaumatin at 2.5 A resolution

de la Cruz, M.J., Hattne, J., Shi, D., Seidler, P., Rodriguez, J., Reyes, F.E., Sawaya, M.R., Cascio, D., Eisenberg, D., Gonen, T.

(2017) Nat Methods 14: 399-402

Released	2017-04-05
Method	ELECTRON CRYSTALLOGRAPHY 2.5 Å
Organisms	Thaumatococcus daniellii
Macromolecule	Thaumatin-1 (protein)

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5K7R \| pdb_00005k7r	Download File View File

MicroED structure of trypsin at 1.7 A resolution

de la Cruz, M.J., Hattne, J., Shi, D., Seidler, P., Rodriguez, J., Reyes, F.E., Sawaya, M.R., Cascio, D., Eisenberg, D., Gonen, T.

(2017) Nat Methods 14: 399-402

Released	2017-04-05
Method	ELECTRON CRYSTALLOGRAPHY 1.7 Å
Organisms	Bos taurus
Macromolecule	Cationic trypsin (protein)
Unique Ligands	CA

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5K7S \| pdb_00005k7s	Download File View File

MicroED structure of proteinase K at 1.6 A resolution

de la Cruz, M.J., Hattne, J., Shi, D., Seidler, P., Rodriguez, J., Reyes, F.E., Sawaya, M.R., Cascio, D., Eisenberg, D., Gonen, T.

(2017) Nat Methods 14: 399-402

Released	2017-04-05
Method	ELECTRON CRYSTALLOGRAPHY 1.6 Å
Organisms	Parengyodontium album
Macromolecule	Proteinase K (protein)
Unique Ligands	CA

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5K7T \| pdb_00005k7t	Download File View File

MicroED structure of thermolysin at 2.5 A resolution

de la Cruz, M.J., Hattne, J., Shi, D., Seidler, P., Rodriguez, J., Reyes, F.E., Sawaya, M.R., Cascio, D., Eisenberg, D., Gonen, T.

(2017) Nat Methods 14: 399-402

Released	2017-04-05
Method	ELECTRON CRYSTALLOGRAPHY 2.5 Å
Organisms	Bacillus thermoproteolyticus
Macromolecule	Thermolysin (protein)
Unique Ligands	CA, DMS, IPA, ZN

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5TX2 \| pdb_00005tx2	Download File View File

Miniature TGF-beta2 3-mutant monomer

Taylor, A.B., Kim, S.K., Hart, P.J., Hinck, A.P.

(2017) J Biological Chem 292: 7173-7188

Released	2017-03-01
Method	X-RAY DIFFRACTION 1.82 Å
Organisms	Mus musculus
Macromolecule	Transforming growth factor beta-2 (protein)

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5TX4 \| pdb_00005tx4	Download File View File

Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130

Hinck, A.P., Kim, S.

(2017) J Biological Chem 292: 7173-7188

Released	2017-03-01
Method	X-RAY DIFFRACTION 1.876 Å
Organisms	Homo sapiens
Macromolecule	TGF-beta receptor type-2 (protein) Transforming growth factor beta-2 (protein)

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5TX6 \| pdb_00005tx6	Download File View File

Structure of TGF-beta2 derivative with deletion of residues 52-71 and 10 single amino acid mutations (mmTGF-beta2-7M)

Petrunak, E.M., Hinck, A.P.

(2017) J Biological Chem 292: 7173-7188

Released	2017-03-01
Method	X-RAY DIFFRACTION 2.746 Å
Organisms	Mus musculus
Macromolecule	Transforming growth factor beta-2 (protein)
Unique Ligands	CA

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5TY4 \| pdb_00005ty4	Download File View File

MicroED structure of a complex between monomeric TGF-b and its receptor, TbRII, at 2.9 A resolution

Weiss, S.C., de la Cruz, M.J., Hattne, J., Shi, D., Reyes, F.E., Callero, G., Gonen, T.

(2017) Nat Methods 14: 399-402

Released	2017-04-26
Method	ELECTRON CRYSTALLOGRAPHY 2.9 Å
Organisms	Homo sapiens
Macromolecule	TGF-beta receptor type-2 (protein) mmTGF-b2-7m (protein)

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6I9J \| pdb_00006i9j	Download File View File

Human transforming growth factor beta2 in a tetragonal crystal form

Gomis-Ruth, F.X., Marino-Puertas, L., del Amo-Maestro, L., Goulas, T.

(2019) Sci Rep 9: 8660-8660

Released	2019-07-03
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Transforming growth factor beta-2 proprotein (protein)

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6MAC \| pdb_00006mac	Download File View File

Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD

Goebel, E.J., Thompson, T.B.

(2019) Proc Natl Acad Sci U S A 116: 15505-15513

Released	2019-07-17
Method	X-RAY DIFFRACTION 2.34 Å
Organisms	Homo sapiens Rattus norvegicus
Macromolecule	Activin receptor type-2B (protein) Growth/differentiation factor 11 (protein) TGF-beta receptor type-1 (protein)
Unique Ligands	NAG

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6MZN \| pdb_00006mzn	Download File View File

Zebrafish betaglycan orphan domain structure from tetragonal crystal form

Hinck, A.P., Kim, S.

(2019) Structure 27: 1427-1442.e4

Released	2019-08-21
Method	X-RAY DIFFRACTION 2.38 Å
Organisms	Danio rerio
Macromolecule	Transforming growth factor beta receptor III (protein)

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6MZP \| pdb_00006mzp	Download File View File

Zebrafish betaglycan orphan domain structure from orthorhombic crystal form

Hinck, A.P., Kim, S.

(2019) Structure 27: 1427-1442.e4

Released	2019-08-21
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Danio rerio
Macromolecule	Transforming growth factor beta receptor III (protein)

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7SXB \| pdb_00007sxb	Download File View File

NMR Solution Structure for Domain 3 of Heligmosomoides polygyrus protein Transforming Growth Factor Beta Mimic 1 (TGM-1 D3)

Mukundan, A., Byeon, C., Hinck, A.P.

(2022) J Biological Chem 298: 101994-101994

Released	2022-05-18
Method	SOLUTION NMR
Organisms	Heligmosomoides polygyrus
Macromolecule	Transforming growth factor mimic (protein)

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8G4K \| pdb_00008g4k	Download File View File

Complex of TbRII mini protein binder bound to the TbRII ECD

Schwartze, T.S., Hinck, A.P.

To be published

Released	2024-08-14
Method	X-RAY DIFFRACTION 1.24 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	5HCS_TGFBR2_1 (protein) TGF-beta receptor type-2 (protein)
Unique Ligands	SO4

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8GAB \| pdb_00008gab	Download File View File

Crystal structure of CTLA-4 in complex with a high affinity CTLA-4 binder

Yang, W., Almo, S.C., Baker, D., Ghosh, A.

(2024) bioRxiv

Released	2024-08-21
Method	X-RAY DIFFRACTION 2.72 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	CTLA-4 binder (protein) Cytotoxic T-lymphocyte protein 4 (protein)
Unique Ligands	K

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8GAC \| pdb_00008gac	Download File View File

Crystal structure of a high affinity CTLA-4 binder

Yang, W., Almo, S.C., Baker, D., Ghosh, A.

(2024) bioRxiv

Released	2024-08-21
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	synthetic construct
Macromolecule	CTLA-4 binder (protein)
Unique Ligands	EDO

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8GAD \| pdb_00008gad	Download File View File

Crystal structure of a high affinity PD-L1 binder

Yang, W., Almo, S.C., Baker, D., Ghosh, A.

(2024) bioRxiv

Released	2024-08-21
Method	X-RAY DIFFRACTION 1.88 Å
Organisms	synthetic construct
Macromolecule	PD-L1 binder (protein)
Unique Ligands	IND

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9B9F \| pdb_00009b9f	Download File View File

Zebrafish Betaglycan Orphan Domain (zfBGo) in complex with TGF-B3 and extracellular domains of TGFBRI and TGFBRII

Wieteska, L., Taylor, A.B., Hinck, A.P.

(2025) Nat Commun 16: 1778-1778

Released	2025-03-12
Method	X-RAY DIFFRACTION 3 Å
Organisms	Danio rerio Homo sapiens
Macromolecule	Transforming growth factor beta receptor type-1 (protein) Transforming growth factor beta receptor type-2 (protein) Transforming growth factor beta receptor type-3 (protein) Transforming growth factor beta-3 (protein) Transforming growth factor beta-3 triple mutant (protein)

1 to 25 of 41 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1KTZ | pdb_00001ktz

2JQE | pdb_00002jqe

2L5S | pdb_00002l5s

2PJY | pdb_00002pjy

5K7N | pdb_00005k7n

5K7O | pdb_00005k7o

5K7P | pdb_00005k7p

5K7Q | pdb_00005k7q

5K7R | pdb_00005k7r

5K7S | pdb_00005k7s

5K7T | pdb_00005k7t

5TX2 | pdb_00005tx2

5TX4 | pdb_00005tx4

5TX6 | pdb_00005tx6

5TY4 | pdb_00005ty4

6I9J | pdb_00006i9j

6MAC | pdb_00006mac

6MZN | pdb_00006mzn

6MZP | pdb_00006mzp

7SXB | pdb_00007sxb

8G4K | pdb_00008g4k

8GAB | pdb_00008gab

8GAC | pdb_00008gac

8GAD | pdb_00008gad

9B9F | pdb_00009b9f