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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "de Ruyck, J."

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Search Summary

This query matches 87 Structures.

Refinements

Structure Determination Methodology

experimental (87)

Scientific Name of Source Organism

	Homo sapiens (72)
	Mus musculus (15)
	synthetic construct (2)

Taxonomy

	Eukaryota (87)
	Eukaryota (eukaryotes) (2)
	other sequences (2)

Experimental Method

	X-RAY DIFFRACTION (81)
	SOLUTION NMR (6)

Polymer Entity Type

Protein (87)

Refinement Resolution (Å)

	1.0 - 1.5 (8)
	1.5 - 2.0 (30)
	2.0 - 2.5 (33)
	2.5 - 3.0 (9)
	3.0 - 3.5 (1)

Release Date

	2000 - 2004 (2)
	2005 - 2009 (26)
	2010 - 2014 (22)
	2015 - 2019 (20)
	2020 - 2024 (17)

Enzyme Classification Name

Transferases (87)

Symmetry Type

	Asymmetric (87)
	Cyclic (4)
	Dihedral (1)

SCOP Classification

	Alpha and beta proteins (a+b) (48)
	Artifacts (26)
	All beta proteins (20)

AllSelected

1 to 25 of 87 Structures

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1OPJ \| pdb_00001opj	Download File View File

Structural basis for the auto-inhibition of c-Abl tyrosine kinase

Nagar, B., Hantschel, O., Young, M.A., Scheffzek, K., Veach, D., Bornmann, W., Clarkson, B., Superti-Furga, G., Kuriyan, J.

(2003) Cell 112: 859-871

Released	2003-04-08
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Mus musculus
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	CL, MYR, STI

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1OPK \| pdb_00001opk	Download File View File

Structural basis for the auto-inhibition of c-Abl tyrosine kinase

Nagar, B., Hantschel, O., Young, M.A., Scheffzek, K., Veach, D., Bornmann, W., Clarkson, B., Superti-Furga, G., Kuriyan, J.

(2003) Cell 112: 859-871

Released	2003-04-08
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Mus musculus
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	GOL, MYR, P16

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1ZZP \| pdb_00001zzp	Download File View File

Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl

Hantschel, O., Wiesner, S., Guttler, T., Mackereth, C.D., Rix, L.L.R., Mikes, Z., Dehne, J., Gorlich, D., Sattler, M., Superti-Furga, G.

(2005) Mol Cell 19: 461-473

Released	2005-08-30
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)

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2F4J \| pdb_00002f4j	Download File View File

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680

Young, M.A., Shah, N.P., Chao, L.H., Zarrinkar, P., Sawyers, P., Kuriyan, J.

(2006) Cancer Res 66: 1007-1014

Released	2006-01-24
Method	X-RAY DIFFRACTION 1.91 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	VX6

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2G1T \| pdb_00002g1t	Download File View File

A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

Levinson, N.M., Kuchment, O.

(2006) PLoS Biol 4: 753-767

Released	2006-05-23
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	ATP-Peptide Conjugate (protein) Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	112, MG

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2G2F \| pdb_00002g2f	Download File View File

A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

Levinson, N.M., Kuchment, O.

(2006) PLoS Biol 4: 753-767

Released	2006-05-23
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	ATP-Peptide Conjugate (protein) Abl Kinase (protein)
Unique Ligands	112, AGS

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2G2H \| pdb_00002g2h	Download File View File

A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

Levinson, N.M., Kuchment, O.

(2006) PLoS Biol 4: 753-767

Released	2006-05-23
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Abl Tyrosine (protein)
Unique Ligands	P16

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2G2I \| pdb_00002g2i	Download File View File

A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

Levinson, N.M., Kuchment, O.

(2006) PLoS Biol 4: 753-767

Released	2006-05-23
Method	X-RAY DIFFRACTION 3.12 Å
Organisms	Homo sapiens
Macromolecule	ATP-Peptide Conjugate (protein) Abl Tyrosine Kinase (protein)
Unique Ligands	ADP

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2GQG \| pdb_00002gqg	Download File View File

X-ray Crystal Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain

Klei, H.E.

(2006) Cancer Res 66: 5790-5797

Released	2006-11-21
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	1N1, GOL

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2HIW \| pdb_00002hiw	Download File View File

Crystal Structure of Inactive Conformation Abl Kinase Catalytic Domain Complexed with Type II Inhibitor

Lee, C.

(2006) Chem Biol 13: 779-786

Released	2006-08-22
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	7MP

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2HYY \| pdb_00002hyy	Download File View File

Human Abl kinase domain in complex with imatinib (STI571, Glivec)

Cowan-Jacob, S.W., Fendrich, G., Liebetanz, J., Fabbro, D., Manley, P.

(2007) Acta Crystallogr D Biol Crystallogr 63: 80-93

Released	2007-01-16
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	STI

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2HZ0 \| pdb_00002hz0	Download File View File

Abl kinase domain in complex with NVP-AEG082

Cowan-Jacob, S.W., Fendrich, G., Liebetanz, J., Fabbro, D., Manley, P.

(2007) Acta Crystallogr D Biol Crystallogr 63: 80-93

Released	2007-01-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	GIN

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2HZ4 \| pdb_00002hz4	Download File View File

Abl kinase domain unligated and in complex with tetrahydrostaurosporine

Cowan-Jacob, S.W., Fendrich, G., Liebetanz, J., Fabbro, D., Manley, P.

(2007) Acta Crystallogr D Biol Crystallogr 63: 80-93

Released	2007-01-16
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	4ST

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2HZI \| pdb_00002hzi	Download File View File

Abl kinase domain in complex with PD180970

Cowan-Jacob, S.W., Fendrich, G., Liebetanz, J., Fabbro, D., Manley, P.

(2007) Acta Crystallogr D Biol Crystallogr 63: 80-93

Released	2007-01-16
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	JIN

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2HZN \| pdb_00002hzn	Download File View File

Abl kinase domain in complex with NVP-AFG210

Cowan-Jacob, S.W., Fendrich, G., Liebetanz, J., Fabbro, D., Manley, P.

(2007) Acta Crystallogr D Biol Crystallogr 63: 80-93

Released	2007-01-16
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Mus musculus
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	KIN

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2O88 \| pdb_00002o88	Download File View File

Crystal structure of the N114A mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

Camara-Artigas, A.

(2007) Acta Crystallogr D Biol Crystallogr 63: 646-652

Released	2007-05-01
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	P41 peptide (protein) Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	SO4

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3CS9 \| pdb_00003cs9	Download File View File

Human ABL kinase in complex with nilotinib

Cowan-Jacob, S.W., Fendrich, G., Manley, P., Liebetanz, J., Fabbro, D.

(2005) Cancer Cell 7: 129-141

Released	2008-04-22
Method	X-RAY DIFFRACTION 2.21 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	NIL

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3DK3 \| pdb_00003dk3	Download File View File

Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

Lewis, H.A.

To be published

Released	2008-07-29
Method	X-RAY DIFFRACTION 2.02 Å
Organisms	Mus musculus
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	SO4, SX7

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3DK6 \| pdb_00003dk6	Download File View File

Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

Lewis, H.A.

To be published

Released	2008-07-29
Method	X-RAY DIFFRACTION 2.02 Å
Organisms	Mus musculus
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	SX7

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3DK7 \| pdb_00003dk7	Download File View File

Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

Lewis, H.A.

To be published

Released	2008-07-29
Method	X-RAY DIFFRACTION 2.01 Å
Organisms	Mus musculus
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	SO4, SX7

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3EG0 \| pdb_00003eg0	Download File View File

Crystal structure of the N114T mutant of ABL-SH3 domain

Camara-Artigas, A.

(2010) J Biological Chem 285: 2823-2833

Released	2009-09-15
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	GOL

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3EG1 \| pdb_00003eg1	Download File View File

Crystal structure of the N114Q mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

Camara-Artigas, A.

(2010) J Biological Chem 285: 2823-2833

Released	2009-09-15
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein) p41 peptide (protein)
Unique Ligands	SO4

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3EG2 \| pdb_00003eg2	Download File View File

Crystal structure of the N114Q mutant of ABL-SH3 domain

Camara-Artigas, A.

(2010) J Biological Chem 285: 2823-2833

Released	2009-09-15
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	GOL

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3EG3 \| pdb_00003eg3	Download File View File

Crystal structure of the N114A mutant of ABL-SH3 domain

Camara-Artigas, A.

(2010) J Biological Chem 285: 2823-2833

Released	2009-09-15
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	GOL

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3EGU \| pdb_00003egu	Download File View File

Crystal structure of the N114A mutant of ABL-SH3 domain

Camara-Artigas, A.

(2010) J Biological Chem 285: 2823-2833

Released	2009-09-15
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	GOL, SO4

1 to 25 of 87 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1OPJ | pdb_00001opj

1OPK | pdb_00001opk

1ZZP | pdb_00001zzp

2F4J | pdb_00002f4j

2G1T | pdb_00002g1t

2G2F | pdb_00002g2f

2G2H | pdb_00002g2h

2G2I | pdb_00002g2i

2GQG | pdb_00002gqg

2HIW | pdb_00002hiw

2HYY | pdb_00002hyy

2HZ0 | pdb_00002hz0

2HZ4 | pdb_00002hz4

2HZI | pdb_00002hzi

2HZN | pdb_00002hzn

2O88 | pdb_00002o88

3CS9 | pdb_00003cs9

3DK3 | pdb_00003dk3

3DK6 | pdb_00003dk6

3DK7 | pdb_00003dk7

3EG0 | pdb_00003eg0

3EG1 | pdb_00003eg1

3EG2 | pdb_00003eg2

3EG3 | pdb_00003eg3

3EGU | pdb_00003egu