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234,785 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Xie, S.C."

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Search Summary

This query matches 16 Structures.

Refinements

Structure Determination Methodology

experimental (16)

Scientific Name of Source Organism

	Plasmodium falciparum 3D7 (10)
	Homo sapiens (5)
	Plasmodium falciparum (1)

Taxonomy

Eukaryota (16)

Experimental Method

	X-RAY DIFFRACTION (9)
	ELECTRON MICROSCOPY (7)

Polymer Entity Type

Protein (16)

Refinement Resolution (Å)

	1.5 - 2.0 (5)
	2.0 - 2.5 (3)
	3.0 - 3.5 (4)
	3.5 - 4.0 (4)

Release Date

	2015 - 2019 (5)
	2020 - 2024 (11)

Enzyme Classification Name

	Hydrolases (7)
	Ligases (8)

Symmetry Type

	Cyclic (15)
	Asymmetric (1)

AllSelected

1 to 16 of 16 Structures

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5FMG \| pdb_00005fmg	Download File View File

Structure and function based design of Plasmodium-selective proteasome inhibitors

Li, H., O'Donoghue, A.J., van der Linden, W.A., Xie, S.C., Yoo, E., Foe, I.T., Tilley, L., Craik, C.S., da Fonseca, P.C.A., Bogyo, M.

(2016) Nature 530: 233

Released	2016-03-02
Method	ELECTRON MICROSCOPY 3.6 Å
Organisms	Plasmodium falciparum
Macromolecule	Unique protein chains: 14
Unique Ligands	7F1

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6DFK \| pdb_00006dfk	Download File View File

Crystal structure of the 11S subunit of the Plasmodium falciparum proteasome, PA28

Xie, S.C., Metcalfe, R.D., Gillett, D.L., Tilley, L., Griffin, M.D.W.

(2019) Nat Microbiol 4: 1990-2000

Released	2019-08-07
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Subunit of proteaseome activator complex,putative (protein)
Unique Ligands	SO4

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6MUV \| pdb_00006muv	Download File View File

The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators

Metcalfe, R.D., Xie, S.C., Hanssen, E., Gillett, D.L., Leis, A.P., Tilley, L., Griffin, M.D.W.

(2019) Nat Microbiol 4: 1990-2000

Released	2019-08-07
Method	ELECTRON MICROSCOPY 3.8 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Unique protein chains: 15

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6MUW \| pdb_00006muw	Download File View File

The structure of the Plasmodium falciparum 20S proteasome.

Metcalfe, R.D., Xie, S.C., Hanssen, E., Gillett, D.L., Leis, A.P., Tilley, L., Griffin, M.D.W.

(2019) Nat Microbiol 4: 1990-2000

Released	2019-08-07
Method	ELECTRON MICROSCOPY 3.6 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Unique protein chains: 14

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6MUX \| pdb_00006mux	Download File View File

The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator

Metcalfe, R.D., Xie, S.C., Hanssen, E., Gillett, D.L., Leis, A.P., Tilley, L., Griffin, M.D.W.

(2019) Nat Microbiol 4: 1990-2000

Released	2019-08-07
Method	ELECTRON MICROSCOPY 3.9 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Unique protein chains: 15

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7LXT \| pdb_00007lxt	Download File View File

Structure of Plasmodium falciparum 20S proteasome with bound bortezomib

Morton, C.J., Metcalfe, R.D., Liu, B., Xie, S.C., Hanssen, E., Leis, A.P., Tilley, L., Griffin, M.D.W.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-09-22
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Unique protein chains: 14
Unique Ligands	BO2

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7LXU \| pdb_00007lxu	Download File View File

Structure of Plasmodium falciparum 20S proteasome with bound MPI-5

Metcalfe, R.D., Morton, C.J., Xie, S.C., Liu, B., Hanssen, E., Leis, A.P., Tilley, L., Griffin, M.D.W.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-09-22
Method	ELECTRON MICROSCOPY 3.1 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Unique protein chains: 14
Unique Ligands	YHD

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7LXV \| pdb_00007lxv	Download File View File

Structure of human 20S proteasome with bound MPI-5

Metcalfe, R.D., Morton, C.J., Liu, B., Xie, S.C., Hanssen, E., Leis, A.P., Tilley, L., Griffin, M.D.W.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-09-22
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Homo sapiens
Macromolecule	Unique protein chains: 14
Unique Ligands	YHD

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7ROR \| pdb_00007ror	Download File View File

Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP

Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2022) Science 376: 1074-1079

Released	2022-06-08
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Tyrosine--tRNA ligase (protein)
Unique Ligands	69X, CL, MG, MLI

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7ROS \| pdb_00007ros	Download File View File

Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML901-Tyr

Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2022) Science 376: 1074-1079

Released	2022-06-08
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Tyrosine--tRNA ligase (protein)
Unique Ligands	66I, CL, MG

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7ROT \| pdb_00007rot	Download File View File

Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr

Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2022) Science 376: 1074-1079

Released	2022-06-08
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Tyrosine--tRNA ligase (protein)
Unique Ligands	66I, CL, MG

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7ROU \| pdb_00007rou	Download File View File

Structure of human tyrosyl tRNA synthetase in complex with ML901-Tyr

Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2022) Science 376: 1074-1079

Released	2022-06-08
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine--tRNA ligase, cytoplasmic (protein)
Unique Ligands	66I, SO4

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8TC7 \| pdb_00008tc7	Download File View File

Human asparaginyl-tRNA synthetase, apo form

Dogovski, C., Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2024) Nat Commun 15: 937-937

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Asparagine--tRNA ligase, cytoplasmic (protein)
Unique Ligands	CL, GOL

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8TC8 \| pdb_00008tc8	Download File View File

Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate

Dogovski, C., Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2024) Nat Commun 15: 937-937

Released	2024-02-07
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Asparagine--tRNA ligase, cytoplasmic (protein)
Unique Ligands	GOL, NA, NSS

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8TC9 \| pdb_00008tc9	Download File View File

Human asparaginyl-tRNA synthetase bound to OSM-S-106

Dogovski, C., Metcalfe, R.D., Xie, S.C., Morton, C.J., Tilley, L., Griffin, M.D.W.

(2024) Nat Commun 15: 937-937

Released	2024-02-07
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Asparagine--tRNA ligase, cytoplasmic (protein)
Unique Ligands	GOL, ZTE

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9CLL \| pdb_00009cll	Download File View File

Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML471-Tyr

Tai, C.W., Dogovski, C., Xie, S.C., Tilley, L., Griffin, M.D.W.

To be published

Released	2024-11-27
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	tyrosine--tRNA ligase (protein)
Unique Ligands	A1AZG, CL, MLI, NA

1 to 16 of 16 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

5FMG | pdb_00005fmg

Structure and function based design of Plasmodium-selective proteasome inhibitors

6DFK | pdb_00006dfk

Crystal structure of the 11S subunit of the Plasmodium falciparum proteasome, PA28

6MUV | pdb_00006muv

The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators

6MUW | pdb_00006muw

The structure of the Plasmodium falciparum 20S proteasome.

6MUX | pdb_00006mux

The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator

7LXT | pdb_00007lxt

Structure of Plasmodium falciparum 20S proteasome with bound bortezomib

7LXU | pdb_00007lxu

Structure of Plasmodium falciparum 20S proteasome with bound MPI-5

7LXV | pdb_00007lxv

Structure of human 20S proteasome with bound MPI-5

7ROR | pdb_00007ror

Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP

7ROS | pdb_00007ros

Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML901-Tyr

7ROT | pdb_00007rot

Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr

7ROU | pdb_00007rou

Structure of human tyrosyl tRNA synthetase in complex with ML901-Tyr

8TC7 | pdb_00008tc7

Human asparaginyl-tRNA synthetase, apo form

8TC8 | pdb_00008tc8

Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate

8TC9 | pdb_00008tc9

Human asparaginyl-tRNA synthetase bound to OSM-S-106

9CLL | pdb_00009cll

Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML471-Tyr

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

5FMG | pdb_00005fmg

6DFK | pdb_00006dfk

6MUV | pdb_00006muv

6MUW | pdb_00006muw

6MUX | pdb_00006mux

7LXT | pdb_00007lxt

7LXU | pdb_00007lxu

7LXV | pdb_00007lxv

7ROR | pdb_00007ror

7ROS | pdb_00007ros

7ROT | pdb_00007rot

7ROU | pdb_00007rou

8TC7 | pdb_00008tc7

8TC8 | pdb_00008tc8

8TC9 | pdb_00008tc9

9CLL | pdb_00009cll