RCSB PDB: Search

3NY8 \| pdb_00003ny8	Download File View File

Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551

Wacker, D., Fenalti, G., Brown, M.A., Katritch, V., Abagyan, R., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)

(2010) J Am Chem Soc 132: 11443-11445

Released	2010-08-11
Method	X-RAY DIFFRACTION 2.84 Å
Organisms	Homo sapiens Tequatrovirus T4
Macromolecule	Beta-2 adrenergic receptor, Lysozyme (protein)
Unique Ligands	CLR, JRZ, OLA, OLC, PGE

Explore in 3D

3NY9 \| pdb_00003ny9	Download File View File

Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist

Fenalti, G., Wacker, D., Brown, M.A., Katritch, V., Abagyan, R., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)

(2010) J Am Chem Soc 132: 11443-11445

Released	2010-08-11
Method	X-RAY DIFFRACTION 2.84 Å
Organisms	Homo sapiens Tequatrovirus T4
Macromolecule	Beta-2 adrenergic receptor, Lysozyme (protein)
Unique Ligands	CLR, JSZ, OLC

Explore in 3D

3NYA \| pdb_00003nya	Download File View File

Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol

Brown, M.A., Wacker, D., Fenalti, G., Katritch, V., Abagyan, R., Cherezov, V., Stevens, R.C., GPCR Network (GPCR)

(2010) J Am Chem Soc 132: 11443-11445

Released	2010-08-11
Method	X-RAY DIFFRACTION 3.16 Å
Organisms	Homo sapiens Tequatrovirus T4
Macromolecule	Beta-2 adrenergic receptor, Lysozyme (protein)
Unique Ligands	CLR, JTZ

Explore in 3D

4DJH \| pdb_00004djh	Download File View File

Structure of the human kappa opioid receptor in complex with JDTic

Wu, H., Wacker, D., Katritch, V., Mileni, M., Han, G.W., Vardy, E., Liu, W., Thompson, A.A., Huang, X.P., Carroll, F.I., Mascarella, S.W., Westkaemper, R.B., Mosier, P.D., Roth, B.L., Cherezov, V., Stevens, R.C., GPCR Network (GPCR)

(2012) Nature 485: 327-332

Released	2012-03-21
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens Tequatrovirus T4
Macromolecule	Kappa-type opioid receptor, Lysozyme (protein)
Unique Ligands	CIT, JDC, OLC, PEG

Explore in 3D

4IAQ \| pdb_00004iaq	Download File View File

Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target)

Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G.W., Liu, W., Huang, X., Vardy, E., McCorvy, J.D., Gao, X., Zhou, E.X., Melcher, K., Zhang, C., Bai, F., Yang, H., Yang, L., Jiang, H., Roth, B.L., Cherezov, V., Stevens, R.C., Xu, H.E., GPCR Network (GPCR)

(2013) Science 340: 610-614

Released	2013-03-13
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562 (protein)
Unique Ligands	2GM

Explore in 3D

4IAR \| pdb_00004iar	Download File View File

Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target)

Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G.W., Liu, W., Huang, X., Vardy, E., McCorvy, J.D., Gao, X., Zhou, E.X., Melcher, K., Zhang, C., Bai, F., Yang, H., Yang, L., Jiang, H., Roth, B.L., Cherezov, V., Stevens, R.C., Xu, H.E., GPCR Network (GPCR)

(2013) Science 340: 610-614

Released	2013-03-13
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562 (protein)
Unique Ligands	ERM, OLB

Explore in 3D

4IB4 \| pdb_00004ib4	Download File View File

Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine

Wacker, D., Wang, C., Katritch, V., Han, G.W., Huang, X., Vardy, E., McCorvy, J.D., Jiang, Y., Chu, M., Siu, F.Y., Liu, W., Xu, H.E., Cherezov, V., Roth, B.L., Stevens, R.C., GPCR Network (GPCR)

(2013) Science 340: 615-619

Released	2013-03-13
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562 (protein)
Unique Ligands	CLR, ERM, OLA, OLB, OLC, PEG, PLM

Explore in 3D

4L6R \| pdb_00004l6r	Download File View File

Structure of the class B human glucagon G protein coupled receptor

Siu, F.Y., He, M., de Graaf, C., Han, G.W., Yang, D., Zhang, Z., Zhou, C., Xu, Q., Wacker, D., Joseph, J.S., Liu, W., Lau, J., Cherezov, V., Katritch, V., Wang, M.W., Stevens, R.C., GPCR Network (GPCR)

(2013) Nature 499: 444-449

Released	2013-07-24
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	Soluble cytochrome b562 and Glucagon receptor chimera (protein)
Unique Ligands	PEG

Explore in 3D

4NC3 \| pdb_00004nc3	Download File View File

Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase.

Liu, W., Wacker, D., Gati, C., Han, G.W., James, D., Wang, D., Nelson, G., Weierstall, U., Katritch, V., Barty, A., Zatsepin, N.A., Li, D., Messerschmidt, M., Boutet, S., Williams, G.J., Koglin, J.E., Seibert, M.M., Wang, C., Shah, S.T.A., Basu, S., Fromme, R., Kupitz, C., Rendek, K.N., Grotjohann, I., Fromme, P., Kirian, R.A., Beyerlein, K.R., White, T.A., Chapman, H.N., Caffrey, M., Spence, J.C.H., Stevens, R.C., Cherezov, V., GPCR Network (GPCR)

(2013) Science 342: 1521-1524

Released	2013-12-18
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562 (protein)
Unique Ligands	CLR, DGA, ERM, OLA, OLC, PEG, PLM, TRS

Explore in 3D

4O9R \| pdb_00004o9r	Download File View File

Human Smoothened Receptor structure in complex with cyclopamine

Wang, C., Weierstall, U., James, D., White, T.A., Wang, D., Liu, W., Spence, J.C.H., Doak, R.B., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N.A., Liu, H., Basu, S., Wacker, D., Han, G.W., Katritch, V., Boutet, S., Messerschmidt, M., Willams, G.J., Koglin, J.E., Seibert, M.M., Klinker, M., Gati, C., Shoeman, R.L., Barty, A., Chapman, H.N., Kirian, R.A., Beyerlein, K.R., Stevens, R.C., Li, D., Shah, S.T.A., Howe, N., Caffrey, M., Cherezov, V., GPCR Network (GPCR)

(2014) Nat Commun 5: 3309-3309

Released	2014-03-05
Method	X-RAY DIFFRACTION 3.204 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	Smoothened homolog/Soluble cytochrome b562 chimeric protein (protein)
Unique Ligands	CY8

Explore in 3D

5TUD \| pdb_00005tud	Download File View File

Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody

Ishchenko, A., Wacker, D., Kapoor, M., Zhang, A., Han, G.W., Basu, S., Boutet, S., James, D., Wang, D., Weierstall, U., Liu, W., Katritch, V., Stevens, R.C., Cherezov, V.

(2017) Proc Natl Acad Sci U S A 114: 8223-8228

Released	2017-07-26
Method	X-RAY DIFFRACTION 3 Å
Organisms	Escherichia coli Homo sapiens Mus musculus
Macromolecule	5-hydroxytryptamine receptor 2B,Soluble cytochrome b562 chimera (protein) Anti-5-HT2B Fab heavy chain (protein) Anti-5-HT2B Fab light chain (protein)
Unique Ligands	ERM

Explore in 3D

5TVN \| pdb_00005tvn	Download File View File

Crystal structure of the LSD-bound 5-HT2B receptor

Wacker, D., Wang, S., McCorvy, J.D., Betz, R.M., Venkatakrishnan, A.J., Levit, A., Lansu, K., Schools, Z.L., Che, T., Nichols, D.E., Shoichet, B.K., Dror, R.O., Roth, B.L.

(2017) Cell 168: 377-389.e12

Released	2017-02-01
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562 (protein)
Unique Ligands	7LD, CLR, OLC, PEG, PO4

Explore in 3D

5WIU \| pdb_00005wiu	Download File View File

Structure of the human D4 Dopamine receptor in complex with Nemonapride

Wacker, D., Wang, S., Levit, A., Che, T., Betz, R.M., McCorvy, J.D., Venkatakrishnan, A.J., Huang, X.-P., Dror, R.O., Shoichet, B.K., Roth, B.L.

(2017) Science 358: 381-386

Released	2017-10-18
Method	X-RAY DIFFRACTION 1.962 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	D(4) dopamine receptor, soluble cytochrome b562 chimera (protein)
Unique Ligands	AQD, GOL, OLA, PEG, PO4

Explore in 3D

5WIV \| pdb_00005wiv	Download File View File

Structure of the sodium-bound human D4 Dopamine receptor in complex with Nemonapride

Wacker, D., Wang, S., Levit, A., Che, T., Betz, R.M., McCorvy, J.D., Venkatakrishnan, A.J., Huang, X.-P., Dror, R.O., Shoichet, B.K., Roth, B.L.

(2017) Science 358: 381-386

Released	2017-10-18
Method	X-RAY DIFFRACTION 2.143 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	D(4) dopamine receptor, soluble cytochrome b562 chimera (protein)
Unique Ligands	AQD, NA, OLA, PEG, PO4

Explore in 3D

6B73 \| pdb_00006b73	Download File View File

Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor

Che, T., Majumdar, S., Zaidi, S.A., Kormos, C., McCorvy, J.D., Wang, S., Mosier, P.D., Uprety, R., Vardy, E., Krumm, B.E., Han, G.W., Lee, M.Y., Pardon, E., Steyaert, J., Huang, X.P., Strachan, R.T., Tribo, A.R., Pasternak, G.W., Carroll, I.F., Stevens, R.C., Cherezov, V., Katritch, V., Wacker, D., Roth, B.L.

(2018) Cell 172: 55-67.e15

Released	2018-01-17
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Escherichia coli Homo sapiens Lama glama
Macromolecule	Nanobody (protein) Soluble cytochrome b562, kappa-type opioid receptor (protein)
Unique Ligands	CLR, CVV, OLA

Explore in 3D

6BQG \| pdb_00006bqg	Download File View File

Crystal structure of 5-HT2C in complex with ergotamine

Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.

(2018) Cell 172: 719-730.e14

Released	2018-02-14
Method	X-RAY DIFFRACTION 3 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	5-hydroxytryptamine receptor 2C,Soluble cytochrome b562 (protein)
Unique Ligands	ERM, OLC

Explore in 3D

6BQH \| pdb_00006bqh	Download File View File

Crystal structure of 5-HT2C in complex with ritanserin

Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.

(2018) Cell 172: 719-730.e14

Released	2018-02-14
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	5-hydroxytryptamine receptor 2C,Soluble cytochrome b562 (protein)
Unique Ligands	E2J, OLA, OLC, PEG

Explore in 3D

6CM4 \| pdb_00006cm4	Download File View File

Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone

Wang, S., Che, T., Levit, A., Shoichet, B.K., Wacker, D., Roth, B.L.

(2018) Nature 555: 269-273

Released	2018-03-14
Method	X-RAY DIFFRACTION 2.867 Å
Organisms	Homo sapiens Tequatrovirus T4
Macromolecule	D(2) dopamine receptor, endolysin chimera (protein)
Unique Ligands	8NU, OLA, PEG

Explore in 3D

6DRX \| pdb_00006drx	Download File View File

Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor

McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.

(2018) Nat Struct Mol Biol 25: 787-796

Released	2018-08-29
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	5HT2B receptor, BRIL chimera (protein)
Unique Ligands	CLR, H8G, OLC

Explore in 3D

6DRY \| pdb_00006dry	Download File View File

Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor

McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.

(2018) Nat Struct Mol Biol 25: 787-796

Released	2018-08-29
Method	X-RAY DIFFRACTION 2.918 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	5HT2B receptor, BRIL chimera (protein)
Unique Ligands	CLR, H8D, OLA, OLC, PEG, PO4

Explore in 3D

6DRZ \| pdb_00006drz	Download File View File

Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor

McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.

(2018) Nat Struct Mol Biol 25: 787-796

Released	2018-08-29
Method	X-RAY DIFFRACTION 3.102 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	5HT2B receptor, BRIL chimera (protein)
Unique Ligands	CLR, H8J, OLA, OLC, PEG, PO4

Explore in 3D

6DS0 \| pdb_00006ds0	Download File View File

Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor

McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.

(2018) Nat Struct Mol Biol 25: 787-796

Released	2018-08-29
Method	X-RAY DIFFRACTION 3.188 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	5HT2B receptor, BRIL chimera (protein)
Unique Ligands	CLR, H8M, OLC, PEG

Explore in 3D

7TY4 \| pdb_00007ty4	Download File View File

Cryo-EM structure of human Anion Exchanger 1

Capper, M.J., Mathiharan, Y.K., Yang, S., Stone, A.C., Wacker, D.

(2023) Nat Struct Mol Biol 30: 1495-1504

Released	2023-08-16
Method	ELECTRON MICROSCOPY 2.99 Å
Organisms	Homo sapiens
Macromolecule	Band 3 anion transport protein (protein)
Unique Ligands	CLR, PC1, Y01
Unique branched monosaccharides	NAG

Explore in 3D

7TY6 \| pdb_00007ty6	Download File View File

Cryo-EM structure of human Anion Exchanger 1 bound to 4,4'-Diisothiocyanatodihydrostilbene-2,2'-Disulfonic Acid (H2DIDS)

Capper, M.J., Mathiharan, Y.K., Yang, S., Stone, A.C., Wacker, D.

(2023) Nat Struct Mol Biol 30: 1495-1504

Released	2023-08-16
Method	ELECTRON MICROSCOPY 2.98 Å
Organisms	Homo sapiens
Macromolecule	Band 3 anion transport protein (protein)
Unique Ligands	4DS, CLR, PC1
Unique branched monosaccharides	NAG

Explore in 3D

7TY7 \| pdb_00007ty7	Download File View File

Cryo-EM structure of human Anion Exchanger 1 bound to Bicarbonate

Capper, M.J., Mathiharan, Y.K., Yang, S., Stone, A.C., Wacker, D.

(2023) Nat Struct Mol Biol 30: 1495-1504

Released	2023-08-16
Method	ELECTRON MICROSCOPY 3.37 Å
Organisms	Homo sapiens
Macromolecule	Band 3 anion transport protein (protein)
Unique Ligands	BCT, CLR, PC1
Unique branched monosaccharides	NAG

Prepare Data

Validate Data

Deposit Data

Help and Resources

Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

3NY8 | pdb_00003ny8

3NY9 | pdb_00003ny9

3NYA | pdb_00003nya

4DJH | pdb_00004djh

4IAQ | pdb_00004iaq

4IAR | pdb_00004iar

4IB4 | pdb_00004ib4

4L6R | pdb_00004l6r

4NC3 | pdb_00004nc3

4O9R | pdb_00004o9r

5TUD | pdb_00005tud

5TVN | pdb_00005tvn

5WIU | pdb_00005wiu

5WIV | pdb_00005wiv

6B73 | pdb_00006b73

6BQG | pdb_00006bqg

6BQH | pdb_00006bqh

6CM4 | pdb_00006cm4

6DRX | pdb_00006drx

6DRY | pdb_00006dry

6DRZ | pdb_00006drz

6DS0 | pdb_00006ds0

7TY4 | pdb_00007ty4

7TY6 | pdb_00007ty6

7TY7 | pdb_00007ty7