RCSB PDB: Search

3PDS \| pdb_00003pds	Download File View File

Irreversible Agonist-Beta2 Adrenoceptor Complex

Rosenbaum, D.M., Zhang, C., Lyons, J.A., Holl, R., Aragao, D., Arlow, D.H., Rasmussen, S.G.F., Choi, H.-J., DeVree, B.T., Sunahara, R.K., Chae, P.S., Gellman, S.H., Dror, R.O., Shaw, D.E., Weis, W.I., Caffrey, M., Gmeiner, P., Kobilka, B.K.

(2011) Nature 469: 236-240

Released	2011-01-12
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Homo sapiens Tequatrovirus T4
Macromolecule	Fusion protein Beta-2 adrenergic receptor/Lysozyme (protein)
Unique Ligands	CLR, ERC, SO4

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3VW7 \| pdb_00003vw7	Download File View File

Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom

Zhang, C., Srinivasan, Y., Arlow, D.H., Fung, J.J., Palmer, D., Zheng, Y., Green, H.F., Pandey, A., Dror, R.O., Shaw, D.E., Weis, W.I., Coughlin, S.R., Kobilka, B.K.

(2012) Nature 492: 387-392

Released	2012-12-12
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens Tequatrovirus T4
Macromolecule	Proteinase-activated receptor 1, Lysozyme (protein)
Unique Ligands	CL, NA, OLC, VPX

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4DAJ \| pdb_00004daj	Download File View File

Structure of the M3 Muscarinic Acetylcholine Receptor

Kruse, A.C., Hu, J., Pan, A.C., Arlow, D.H., Rosenbaum, D.M., Rosemond, E., Green, H.F., Liu, T., Chae, P.S., Dror, R.O., Shaw, D.E., Weis, W.I., Wess, J., Kobilka, B.

(2012) Nature 482: 552-556

Released	2012-02-22
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	Rattus norvegicus Tequatrovirus T4
Macromolecule	Muscarinic acetylcholine receptor M3, Lysozyme (protein)
Unique Ligands	0HK, PO4

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5C1M \| pdb_00005c1m	Download File View File

Crystal structure of active mu-opioid receptor bound to the agonist BU72

Huang, W.J., Manglik, A., Venkatakrishnan, A.J., Laeremans, T., Feinberg, E.N., Sanborn, A.L., Kato, H.E., Livingston, K.E., Thorsen, T.S., Kling, R., Granier, S., Gmeiner, P., Husbands, S.M., Traynor, J.R., Weis, W.I., Steyaert, J., Dror, R.O., Kobilka, B.K.

(2015) Nature 524: 315-321

Released	2015-08-05
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Lama glama Mus musculus
Macromolecule	Mu-type opioid receptor (protein) Nanobody 39 (protein)
Unique Ligands	CLR, OLC, P6G, PO4, VF1

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5TVN \| pdb_00005tvn	Download File View File

Crystal structure of the LSD-bound 5-HT2B receptor

Wacker, D., Wang, S., McCorvy, J.D., Betz, R.M., Venkatakrishnan, A.J., Levit, A., Lansu, K., Schools, Z.L., Che, T., Nichols, D.E., Shoichet, B.K., Dror, R.O., Roth, B.L.

(2017) Cell 168: 377-389.e12

Released	2017-02-01
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562 (protein)
Unique Ligands	7LD, CLR, OLC, PEG, PO4

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5W0P \| pdb_00005w0p	Download File View File

Crystal structure of rhodopsin bound to visual arrestin determined by X-ray free electron laser

Zhou, X.E., He, Y., de Waal, P.W., Gao, X., Kang, Y., Van Eps, N., Yin, Y., Pal, K., Goswami, D., White, T.A., Barty, A., Latorraca, N.R., Chapman, H.N., Hubbell, W.L., Dror, R.O., Stevens, R.C., Cherezov, V., Gurevich, V.V., Griffin, P.R., Ernst, O.P., Melcher, K., Xu, H.E.

(2017) Cell 170: 457-469.e13

Released	2017-08-09
Method	X-RAY DIFFRACTION 3.013 Å
Organisms	Enterobacteria phage RB55 Homo sapiens Mus musculus
Macromolecule	Endolysin,Rhodopsin,S-arrestin (protein)
Unique branched monosaccharides	NAG

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5WIU \| pdb_00005wiu	Download File View File

Structure of the human D4 Dopamine receptor in complex with Nemonapride

Wacker, D., Wang, S., Levit, A., Che, T., Betz, R.M., McCorvy, J.D., Venkatakrishnan, A.J., Huang, X.-P., Dror, R.O., Shoichet, B.K., Roth, B.L.

(2017) Science 358: 381-386

Released	2017-10-18
Method	X-RAY DIFFRACTION 1.962 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	D(4) dopamine receptor, soluble cytochrome b562 chimera (protein)
Unique Ligands	AQD, GOL, OLA, PEG, PO4

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5WIV \| pdb_00005wiv	Download File View File

Structure of the sodium-bound human D4 Dopamine receptor in complex with Nemonapride

Wacker, D., Wang, S., Levit, A., Che, T., Betz, R.M., McCorvy, J.D., Venkatakrishnan, A.J., Huang, X.-P., Dror, R.O., Shoichet, B.K., Roth, B.L.

(2017) Science 358: 381-386

Released	2017-10-18
Method	X-RAY DIFFRACTION 2.143 Å
Organisms	Escherichia coli Homo sapiens
Macromolecule	D(4) dopamine receptor, soluble cytochrome b562 chimera (protein)
Unique Ligands	AQD, NA, OLA, PEG, PO4

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5X7D \| pdb_00005x7d	Download File View File

Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist

Liu, X., Ahn, S., Kahsai, A.W., Meng, K.-C., Latorraca, N.R., Pani, B., Venkatakrishnan, A.J., Masoudi, A., Weis, W.I., Dror, R.O., Chen, X., Lefkowitz, R.J., Kobilka, B.K.

(2017) Nature 548: 480-484

Released	2017-08-16
Method	X-RAY DIFFRACTION 2.703 Å
Organisms	Homo sapiens Tequatrovirus T4
Macromolecule	Chimera protein of Beta-2 adrenergic receptor and Lysozyme (protein)
Unique Ligands	8VS, ACM, BU1, CAU, CLR, EPE

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6MXT \| pdb_00006mxt	Download File View File

Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71

Masureel, M., Zou, Y., Picard, L.P., van der Westhuizen, E., Mahoney, J.P., Rodrigues, J.P.G.L.M., Mildorf, T.J., Dror, R.O., Shaw, D.E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R.K., Weis, W.I., Zhang, C., Kobilka, B.K.

(2018) Nat Chem Biol 14: 1059-1066

Released	2018-11-14
Method	X-RAY DIFFRACTION 2.95934213525 Å
Organisms	Homo sapiens Lama glama Tequatrovirus T4
Macromolecule	Endolysin, Beta-2 adrenergic receptor chimera (protein) nanobody Nb71 (protein)
Unique Ligands	HTO, K5Y, MG, NI, OLA, OLC, P33

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6O3C \| pdb_00006o3c	Download File View File

Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8

Deshpande, I.S., Liang, J., Hedeen, D., Roberts, K.J., Zhang, Y., Ha, B., Latorraca, N.R., Faust, B., Dror, R.O., Beachy, P.A., Myers, B.R., Manglik, A.

(2019) Nature 571: 284-288

Released	2019-07-03
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Lama glama Mus musculus
Macromolecule	NbSmo8 (protein) Smoothened homolog (protein)
Unique Ligands	CLR, LKD, NA, NAG, OLB, PO4

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6W4S \| pdb_00006w4s	Download File View File

Structure of apo human ferroportin in lipid nanodisc

Billesboelle, C.B., Azumaya, C.M., Gonen, S., Powers, A., Kretsch, R.C., Schneider, S., Arvedson, T., Dror, R.O., Cheng, Y., Manglik, A.

(2020) Nature 586: 807-811

Released	2020-09-09
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Fab45D8 Heavy Chain (protein) Fab45D8 Light Chain (protein) Solute carrier family 40 member 1 (protein)

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6W4V \| pdb_00006w4v	Download File View File

Structure of anti-ferroportin Fab45D8

Billesboelle, C.B., Azumaya, C.M., Gonen, S., Powers, A., Kretsch, R.C., Schneider, S., Arvedson, T., Dror, R.O., Cheng, Y., Manglik, A.

(2020) Nature 586: 807-811

Released	2020-09-09
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Mus musculus
Macromolecule	Fab45D8 Heavy Chain (protein) Fab45D8 Light Chain (protein)
Unique Ligands	EDO

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6WBV \| pdb_00006wbv	Download File View File

Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc

Billesboelle, C.B., Azumaya, C.M., Gonen, S., Powers, A., Kretsch, R.C., Schneider, S., Arvedson, T., Dror, R.O., Cheng, Y., Manglik, A.

(2020) Nature 586: 807-811

Released	2020-09-09
Method	ELECTRON MICROSCOPY 2.5 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Fab45D8 Heavy Chain (protein) Fab45D8 Light Chain (protein) Hepcidin (protein) Solute carrier family 40 member 1 (protein)
Unique Ligands	AGA, CO

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7RMG \| pdb_00007rmg	Download File View File

Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70

Harris, J.A., Faust, B., Gondin, A.B., Daemgen, M.A., Suomivuori, C.M., Veldhuis, N.A., Cheng, Y., Dror, R.O., Thal, D., Manglik, A.

(2022) Nat Chem Biol 18: 109-115

Released	2021-11-03
Method	ELECTRON MICROSCOPY 3 Å
Organisms	Homo sapiens Lama glama
Macromolecule	Unique protein chains: 6

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7RMH \| pdb_00007rmh	Download File View File

Substance P bound to active human neurokinin 1 receptor in complex with miniGs399

Harris, J.A., Faust, B., Gondin, A.B., Daemgen, M.A., Suomivuori, C.M., Veldhuis, N.A., Cheng, Y., Dror, R.O., Thal, D., Manglik, A.

(2022) Nat Chem Biol 18: 109-115

Released	2021-11-03
Method	ELECTRON MICROSCOPY 3.1 Å
Organisms	Homo sapiens Lama glama
Macromolecule	Unique protein chains: 6

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7RMI \| pdb_00007rmi	Download File View File

SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with miniGs/q70

Harris, J.A., Faust, B., Gondin, A.B., Daemgen, M.A., Suomivuori, C.M., Veldhuis, N.A., Cheng, Y., Dror, R.O., Thal, D., Manglik, A.

(2022) Nat Chem Biol 18: 109-115

Released	2021-11-03
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens Lama glama synthetic construct
Macromolecule	Unique protein chains: 6

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8TA2 \| pdb_00008ta2	Download File View File

Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42

Xu, M., Neelands, T., Powers, A.S., Liu, Y., Miller, S., Pintilie, G., Du Bois, J., Dror, R.O., Chiu, W., Maduke, M.

(2024) Elife 12:

Released	2024-01-31
Method	ELECTRON MICROSCOPY 2.74 Å
Organisms	Homo sapiens
Macromolecule	Chloride channel protein 2 (protein)
Unique Ligands	CL, GH6

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8TA3 \| pdb_00008ta3	Download File View File

Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain Apo state with resolved N-terminal hairpin

Xu, M., Neelands, T., Powers, A.S., Liu, Y., Miller, S., Pintilie, G., Du Bois, J., Dror, R.O., Chiu, W., Maduke, M.

(2024) Elife 12:

Released	2024-01-31
Method	ELECTRON MICROSCOPY 2.46 Å
Organisms	Homo sapiens
Macromolecule	Chloride channel protein 2 (protein)
Unique Ligands	CL

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8TA4 \| pdb_00008ta4	Download File View File

Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal

Xu, M., Neelands, T., Powers, A.S., Liu, Y., Miller, S., Pintilie, G., Du Bois, J., Dror, R.O., Chiu, W., Maduke, M.

(2024) Elife 12:

Released	2024-01-31
Method	ELECTRON MICROSCOPY 2.75 Å
Organisms	Homo sapiens
Macromolecule	Chloride channel protein 2 (protein)
Unique Ligands	CL

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8TA5 \| pdb_00008ta5	Download File View File

Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal

Xu, M., Neelands, T., Powers, A.S., Liu, Y., Miller, S., Pintilie, G., Du Bois, J., Dror, R.O., Chiu, W., Maduke, M.

(2024) Elife 12:

Released	2024-01-31
Method	ELECTRON MICROSCOPY 2.76 Å
Organisms	Homo sapiens
Macromolecule	Chloride channel protein 2 (protein)

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8TA6 \| pdb_00008ta6	Download File View File

Cryo-EM structure of the human CLC-2 chloride channel C-terminal domain

Xu, M., Neelands, T., Powers, A.S., Liu, Y., Miller, S., Pintilie, G., Du Bois, J., Dror, R.O., Chiu, W., Maduke, M.

(2024) Elife 12:

Released	2024-01-31
Method	ELECTRON MICROSCOPY 4.03 Å
Organisms	Homo sapiens
Macromolecule	Chloride channel protein 2 (protein)

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

3PDS | pdb_00003pds

3VW7 | pdb_00003vw7

4DAJ | pdb_00004daj

5C1M | pdb_00005c1m

5TVN | pdb_00005tvn

5W0P | pdb_00005w0p

5WIU | pdb_00005wiu

5WIV | pdb_00005wiv

5X7D | pdb_00005x7d

6MXT | pdb_00006mxt

6O3C | pdb_00006o3c

6W4S | pdb_00006w4s

6W4V | pdb_00006w4v

6WBV | pdb_00006wbv

7RMG | pdb_00007rmg

7RMH | pdb_00007rmh

7RMI | pdb_00007rmi

8TA2 | pdb_00008ta2

8TA3 | pdb_00008ta3

8TA4 | pdb_00008ta4

8TA5 | pdb_00008ta5

8TA6 | pdb_00008ta6