RCSB PDB: Search

Warning You are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox.

Help

Help

RCSB PDB

Deposit
- PDBx/mmCIF file
- pdb_extract
- SF-Tool
- Ligand Expo
- MAXIT
- Validation Server
- Validation API
- Information for Journals
- Validation Task Forces
- wwPDB OneDep System
- PDB-IHM
Search
Visualize
Analyze
Download
Learn
- Training Courses
- Guide to PDB Data
- Molecule of the Month
- Educational Resources
- Curricula
- Browse
- News
- SciArt Galleries
- Irving Geis
- David Goodsell
About
Careers
COVID-19

234,785 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

	Include CSM
Advanced Search \| Browse Annotations		Help

Search
Query History
Browse Annotations
MyPDB

QUERY: Structure Author = "Brazzolotto, X."

MyPDB Login

Search API

Advanced Search Query Builder

Help

Full Text

Structure Attributes

Help

NOT

Count

Add Subquery

Chemical Attributes

Sequence Similarity

Sequence Motif

Structure Similarity

Structure Motif

Chemical Similarity

Return

grouped by

Include Computed Structure Models (CSM)

Count

Clear

Search Summary

This query matches 61 Structures.

Refinements

Structure Determination Methodology

experimental (61)

Scientific Name of Source Organism

	Homo sapiens (55)
	Vaccinia virus Copenhagen (5)
	Tetronarce californica (1)

Taxonomy

	Eukaryota (56)
	Varidnaviria (5)

Experimental Method

X-RAY DIFFRACTION (61)

Polymer Entity Type

Protein (61)

Refinement Resolution (Å)

	1.5 - 2.0 (7)
	2.0 - 2.5 (30)
	2.5 - 3.0 (22)
	3.0 - 3.5 (2)

Release Date

	2010 - 2014 (3)
	2015 - 2019 (26)
	2020 - 2024 (31)
	2025 - 2029 (1)

Enzyme Classification Name

Hydrolases (61)

Membrane Protein Annotation

OPM (3)

Symmetry Type

	Asymmetric (51)
	Cyclic (10)
	Dihedral (2)

SCOP Classification

	Alpha and beta proteins (a/b) (33)
	Artifacts (5)

AllSelected

1 to 25 of 61 Structures

Page 1 of 3

Sort by

Explore in 3D

4AQD \| pdb_00004aqd	Download File View File

Crystal structure of fully glycosylated human butyrylcholinesterase

Brazzolotto, X., Wandhammer, M., Ronco, C., Trovaslet, M., Jean, L., Lockridge, O., Renard, P.Y., Nachon, F.

(2012) FEBS J 279: 2905-2916

Released	2012-07-04
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	BUTYRYLCHOLINESTERASE (protein)
Unique Ligands	BAL, CL, EDO, GLY, NAG, PEG, PG4, UNX
Unique branched monosaccharides	FUL, MAN, NAG

Explore in 3D

4OD8 \| pdb_00004od8	Download File View File

Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminus

Contesto-Richefeu, C., Tarbouriech, N., Brazzolotto, X., Burmeister, W.P., Iseni, F.

(2014) PLoS Pathog 10: e1003978-e1003978

Released	2014-03-26
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Vaccinia virus Copenhagen
Macromolecule	DNA polymerase processivity factor component A20 (protein) Uracil-DNA glycosylase (protein)
Unique Ligands	GOL, SO4

Explore in 3D

4ODA \| pdb_00004oda	Download File View File

Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminus

Contesto-Richefeu, C., Tarbouriech, N., Brazzolotto, X., Burmeister, W.P., Iseni, F.

(2014) PLoS Pathog 10: e1003978-e1003978

Released	2014-03-26
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Vaccinia virus Copenhagen
Macromolecule	DNA polymerase processivity factor component A20 (protein) Uracil-DNA glycosylase (protein)
Unique Ligands	GOL, SO4

Explore in 3D

4XII \| pdb_00004xii	Download File View File

X-ray structure of human butyrylcholinesterase in complex with N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-8-hydroxy-N-(2-methoxyethyl)-5-nitroquinoline-7-carboxamide

Knez, D., Boris, B., Coquelle, N., Sosic, I., Sink, R., Brazzolotto, X., Mravljak, J., Colletier, J.P., Gobec, S.

(2015) Bioorg Med Chem 23: 4442-4452

Released	2015-07-08
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	40V, CL, EDO, FUC, FUL, NAG
Unique branched monosaccharides	FUL, NAG

Explore in 3D

5JKR \| pdb_00005jkr	Download File View File

vaccinia virus D4/A20(1-50)w43a mutant

Contesto-Richefeu, C., Tarbouriech, N., Brazzolotto, X., Burmeister, W.P., Peyrefitte, C.N., Iseni, F.

(2016) Acta Crystallogr F Struct Biol Commun 72: 687-691

Released	2016-09-14
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Vaccinia virus Copenhagen
Macromolecule	DNA polymerase processivity factor component A20 (protein) Uracil-DNA glycosylase (protein)
Unique Ligands	SO4

Explore in 3D

5JKS \| pdb_00005jks	Download File View File

vaccinia virus D4 R167A mutant /A20(1-50)

Contesto-Richefeu, C., Tarbouriech, N., Brazzolotto, X., Burmeister, W.P., Peyrefitte, C.N., Iseni, F.

(2016) Acta Crystallogr F Struct Biol Commun 72: 687-691

Released	2016-09-14
Method	X-RAY DIFFRACTION 2.79 Å
Organisms	Vaccinia virus Copenhagen
Macromolecule	DNA polymerase processivity factor component A20 (protein) Uracil-DNA glycosylase (protein)
Unique Ligands	SO4

Explore in 3D

5JKT \| pdb_00005jkt	Download File View File

vaccinia virus D4 P173G mutant /A20(1-50)

Contesto-Richefeu, C., Tarbouriech, N., Brazzolotto, X., Burmeister, W.P., Peyrefitte, C.N., Iseni, F.

(2016) Acta Crystallogr F Struct Biol Commun 72: 687-691

Released	2016-09-14
Method	X-RAY DIFFRACTION 2.49 Å
Organisms	Vaccinia virus Copenhagen
Macromolecule	DNA polymerase processivity factor component A20 (protein) Uracil-DNA glycosylase (protein)
Unique Ligands	ACT, SO4

Explore in 3D

5K5E \| pdb_00005k5e	Download File View File

Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening

De la Mora, E., Dighe, S.N., Deora, G.S., Ross, B.P., Nachon, F., Brazzolotto, X.

(2016) J Med Chem 59: 7683-7689

Released	2016-07-27
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	6QS, EDO, GOL, NAG
Unique branched monosaccharides	NAG

Explore in 3D

6EMI \| pdb_00006emi	Download File View File

Crystal structure of a variant of human butyrylcholinesterase expressed in bacteria.

Brazzolotto, X., Igert, A., Guillon, V., Santoni, G., Nachon, F.

(2017) Molecules 22:

Released	2017-11-08
Method	X-RAY DIFFRACTION 2.476 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	CL, EDO, PEG, PG4, PGE

Explore in 3D

6EP4 \| pdb_00006ep4	Download File View File

Human butyrylcholinesterase in complex with decamethonium

Nachon, F., Brazzolotto, X., Wandhammer, M., Trovaslet-Leroy, M., Rosenberry, T.L., Macdonald, I.R., Darvesh, S.

(2017) Molecules 22:

Released	2017-12-13
Method	X-RAY DIFFRACTION 2.30005381157 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	CL, DME, NAG, SO4
Unique branched monosaccharides	FUL, NAG

Explore in 3D

6EQP \| pdb_00006eqp	Download File View File

Human butyrylcholinesterase in complex with ethopropazine

Nachon, F., Brazzolotto, X., Wandhammer, M., Trovaslet-Leroy, M., Rosenberry, T.L., Macdonald, I.R., Darvesh, S.

(2017) Molecules 22:

Released	2017-12-13
Method	X-RAY DIFFRACTION 2.34941708483 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	BUW, CL, NAG, SO4, ZN
Unique branched monosaccharides	FUC, FUL, NAG

Explore in 3D

6EQQ \| pdb_00006eqq	Download File View File

Human butyrylcholinesterase in complex with huprine 19

Nachon, F., Brazzolotto, X., Wandhammer, M., Trovaslet-Leroy, M., Rosenberry, T.L., Macdonald, I.R., Darvesh, S.

(2017) Molecules 22:

Released	2017-12-13
Method	X-RAY DIFFRACTION 2.40000447819 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	BR, CL, GOL, H19, NAG, SO4, UNL
Unique branched monosaccharides	FUL, NAG

Explore in 3D

6ESJ \| pdb_00006esj	Download File View File

Human butyrylcholinesterase in complex with propidium

Nachon, F., Brazzolotto, X., Wandhammer, M., Trovaslet-Leroy, M., Macdonald, I.R., Darvesh, S., Rosenberry, T.L.

(2017) Molecules 22:

Released	2017-12-13
Method	X-RAY DIFFRACTION 2.97984513804 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	CL, GLY, NAG, PRM
Unique branched monosaccharides	NAG

Explore in 3D

6ESY \| pdb_00006esy	Download File View File

Human butyrylcholinesterase in complex with thioflavine T

Nachon, F., Brazzolotto, X., Wandhammer, M., Trovaslet-Leroy, M., Macdonald, I.R., Darvesh, S., Rosenberry, T.L.

(2017) Molecules 22:

Released	2017-12-13
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	CL, NAG, TFX
Unique branched monosaccharides	FUC, NAG

Explore in 3D

6EUE \| pdb_00006eue	Download File View File

Rivastigmine analogue bound to Tc ACHE.

De la Mora, E., Brazzolotto, X., Dighe, S.N., Silman, I., Weik, M., Ross, B.

(2019) Commun Chem

Released	2018-11-14
Method	X-RAY DIFFRACTION 2 Å
Organisms	Tetronarce californica
Macromolecule	Acetylcholinesterase (protein)
Unique Ligands	1PE, NAG

Explore in 3D

6EYF \| pdb_00006eyf	Download File View File

Butyrylcolinesterase expressed in CHO cells co-crystallised with a rivastigmine analogue

Brazzolotto, X., De la Mora, E., Dighe, S., Ross, B.

(2019) Commun Chem

Released	2018-11-21
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	BY2, GOL, NAG, SO4

Explore in 3D

6EZ2 \| pdb_00006ez2	Download File View File

Human butyrylcholinesterase carbamylated.

Brazzolotto, X., de la Mora, E., Dighe, S.N., Ross, B.P.

(2019) Commun Chem

Released	2018-12-12
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	CL, EDO, GOL, NAG
Unique branched monosaccharides	NAG

Explore in 3D

6H0T \| pdb_00006h0t	Download File View File

Crystal structure of native recombinant human bile salt activated lipase

Touvrey, C., Brazzolotto, X., Nachon, F.

(2019) Toxicology 411: 15-23

Released	2019-03-27
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Bile salt-activated lipase (protein)
Unique Ligands	ACT, GOL, ZN

Explore in 3D

6H0V \| pdb_00006h0v	Download File View File

Crystal structure of tabun surrogate NEDPA inhibited recombinant human bile salt activated lipase

Touvrey, C., Brazzolotto, X., Nachon, F.

(2019) Toxicology 411: 15-23

Released	2019-03-27
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Bile salt-activated lipase (protein)
Unique Ligands	ACT, ZN

Explore in 3D

6H18 \| pdb_00006h18	Download File View File

Crystal structure of sarin surrogate NIMP inhibited recombinant human bile salt activated lipase

Touvrey, C., Brazzolotto, X., Nachon, F.

(2019) Toxicology 411: 15-23

Released	2019-03-27
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Bile salt-activated lipase (protein)
Unique Ligands	ACT, ZN

Explore in 3D

6H19 \| pdb_00006h19	Download File View File

Crystal structure of ethyl-paraoxon inhibited recombinant human bile salt activated lipase (aged form)

Touvrey, C., Brazzolotto, X., Nachon, F.

(2019) Toxicology 411: 15-23

Released	2019-03-27
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Homo sapiens
Macromolecule	Bile salt-activated lipase (protein)
Unique Ligands	ACT, NA, ZN

Explore in 3D

6H1A \| pdb_00006h1a	Download File View File

Crystal structure of VX surrogate NEMP inhibited recombinant human bile salt activated lipase

Touvrey, C., Brazzolotto, X., Nachon, F.

(2019) Toxicology 411: 15-23

Released	2019-03-27
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Bile salt-activated lipase (protein)
Unique Ligands	ACT, ZN

Explore in 3D

6I0B \| pdb_00006i0b	Download File View File

Human butyrylcholinesterase in complex with the S enantiomer of a chlorotacrine-tryptophan multi-target inhibitor.

Brazzolotto, X., Nachon, F.

(2019) Eur J Med Chem 168: 491-514

Released	2019-03-27
Method	X-RAY DIFFRACTION 2.384 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	9A5, CL, GOL, MES, NAG, SO4
Unique branched monosaccharides	FUC, NAG

Explore in 3D

6I0C \| pdb_00006i0c	Download File View File

Human butyrylcholinesterase in complex with the R enantiomer of a chlorotacrine-tryptophan multi-target inhibitor.

Brazzolotto, X., Nachon, F.

(2019) Eur J Med Chem 168: 491-514

Released	2019-03-27
Method	X-RAY DIFFRACTION 2.675 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	GZ5, MES, NA, NAG, SO4
Unique branched monosaccharides	FUC, NAG

Explore in 3D

6QAA \| pdb_00006qaa	Download File View File

Human Butyrylcholinesterase in complex with (S)-2-(butylamino)-N-(2-cycloheptylethyl)-3-(1H-indol-3-yl)propanamide

Brazzolotto, X., Nachon, F., Harst, M., Knez, D., Gobec, S.

(2019) Chem Commun (Camb) 55: 3765-3768

Released	2019-03-27
Method	X-RAY DIFFRACTION 1.897 Å
Organisms	Homo sapiens
Macromolecule	Cholinesterase (protein)
Unique Ligands	DMS, GOL, HUN, MES, NAG, SO4
Unique branched monosaccharides	FUC, NAG

1 to 25 of 61 Structures

Page 1 of 3

Sort by

About
About Us
Citing Us
Publications
Team
Careers
Usage & Privacy

Support
Contact Us
Help
Website FAQ
Glossary
Service Status

RCSB PDB is hosted by

RCSB PDB is a member of the

RCSB Partners
Nucleic Acid Knowledgebase

wwPDB Partners
RCSB PDB
PDBe
PDBj
BMRB
EMDB

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

Prepare Data

Validate Data

Deposit Data

Help and Resources

Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

4AQD | pdb_00004aqd

4OD8 | pdb_00004od8

4ODA | pdb_00004oda

4XII | pdb_00004xii

5JKR | pdb_00005jkr

5JKS | pdb_00005jks

5JKT | pdb_00005jkt

5K5E | pdb_00005k5e

6EMI | pdb_00006emi

6EP4 | pdb_00006ep4

6EQP | pdb_00006eqp

6EQQ | pdb_00006eqq

6ESJ | pdb_00006esj

6ESY | pdb_00006esy

6EUE | pdb_00006eue

6EYF | pdb_00006eyf

6EZ2 | pdb_00006ez2

6H0T | pdb_00006h0t

6H0V | pdb_00006h0v

6H18 | pdb_00006h18

6H19 | pdb_00006h19

6H1A | pdb_00006h1a

6I0B | pdb_00006i0b

6I0C | pdb_00006i0c

6QAA | pdb_00006qaa