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232,829 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 5.2.1.8

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Search Summary

This query matches 3,403 Structures.

Refinements

Structure Determination Methodology

	computational (2,198)
	experimental (1,205)

CSM Source Database

	AlphaFoldDB (2,197)
	ModelArchive (1)

pLDDT Global Quality Score

	< 50.0 (10)
	50.0 - 70.0 (113)
	70.0 - 90.0 (926)
	> 90.0 (1,149)

Scientific Name of Source Organism

	Homo sapiens (870)
	Glycine max (95)
	Oryctolagus cuniculus (88)
	Arabidopsis thaliana (68)
	Zea mays (64)
	Mus musculus (52)
	Oryza sativa Japonica Group (50)
	Escherichia coli (46)
	Trypanosoma cruzi strain CL Brener (46)
	Tolypocladium inflatum (44)

More...

Taxonomy

	Eukaryota (2,162)
	Bacteria (1,251)
	other sequences (24)
	Riboviria (22)
	Varidnaviria (17)
	Archaea (13)
	Eukaryota (eukaryotes) (7)
	Duplodnaviria (2)
	Monodnaviria (2)

Experimental Method

	X-RAY DIFFRACTION (833)
	ELECTRON MICROSCOPY (272)
	SOLUTION NMR (99)
	ELECTRON CRYSTALLOGRAPHY (1)

Polymer Entity Type

	Protein (3,403)
	RNA (76)
	DNA (5)

Refinement Resolution (Å)

	0.5 - 1.0 (21)
	1.0 - 1.5 (184)
	1.5 - 2.0 (366)
	2.0 - 2.5 (179)
	2.5 - 3.0 (102)
	3.0 - 3.5 (87)
	3.5 - 4.0 (72)
	4.0 - 4.5 (40)
	> 4.5 (55)

Release Date

	1990 - 1994 (14)
	1995 - 1999 (59)
	2000 - 2004 (70)
	2005 - 2009 (124)
	2010 - 2014 (203)
	2015 - 2019 (238)
	2020 - 2024 (2,648)
	2025 - 2029 (47)

Enzyme Classification Name

	Isomerases (3,403)
	Hydrolases (105)
	Transferases (122)
	Translocases (5)
	Oxidoreductases (12)
	Ligases (6)
	Lyases (2)

Membrane Protein Annotation

	mpstruc (48)
	OPM (29)
	PDBTM (29)
	MemProtMD (14)

Symmetry Type

	Asymmetric (3,154)
	Cyclic (260)
	Dihedral (15)
	Helical (1)
	Octahedral (1)

SCOP Classification

	All beta proteins (334)
	Alpha and beta proteins (a+b) (296)
	Artifacts (139)
	All alpha proteins (61)
	Low resolution protein structures (1)
	Alpha and beta proteins (a/b) (11)
	Small proteins (5)
	Coiled coil proteins (4)
	Peptides (2)
	Multi-domain proteins (alpha and beta) (1)

AllSelected

1 to 25 of 3,403 Structures

Page 1 of 137

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1A33	Download File View File

PEPTIDYLPROLYL ISOMERASE, CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI

Mikol, V., Ma, D., Carlow, C.K.S.

(1998) Protein Sci 7: 1310-1316

Released	1998-07-29
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Brugia malayi
Macromolecule	PEPTIDYLPROLYL ISOMERASE (protein)

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1A58	Download File View File

CYCLOPHILIN FROM BRUGIA MALAYI

Taylor, P., Page, A.P., Kontopidis, G., Husi, H., Walkinshaw, M.D.

(1998) FEBS Lett 425: 361-366

Released	1998-05-27
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Brugia malayi
Macromolecule	CYCLOPHILIN (protein)

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1A7X	Download File View File

FKBP12-FK1012 COMPLEX

Schultz, L.W., Clardy, J.

(1998) Bioorg Med Chem Lett 8: 1-6

Released	1998-06-17
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	FKBP12 (protein)
Unique Ligands	FKA

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1AK4	Download File View File

HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID

Hill, C.P., Gamble, T.R., Vajdos, F.F., Worthylake, D.K., Sundquist, W.I.

(1996) Cell 87: 1285-1294

Released	1997-10-15
Method	X-RAY DIFFRACTION 2.36 Å
Organisms	Homo sapiens Human immunodeficiency virus 1
Macromolecule	CYCLOPHILIN A (protein) HIV-1 CAPSID (protein)

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1AWQ	Download File View File

CYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER)

Vajdos, F.F.

(1997) Protein Sci 6: 2297-2307

Released	1998-03-18
Method	X-RAY DIFFRACTION 1.58 Å
Organisms	Homo sapiens
Macromolecule	CYCLOPHILIN A (protein) PEPTIDE FROM THE HIV-1 CAPSID PROTEIN (protein)

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1AWR	Download File View File

CYPA COMPLEXED WITH HAGPIA

Vajdos, F.F.

(1997) Protein Sci 6: 2297-2307

Released	1998-03-18
Method	X-RAY DIFFRACTION 1.58 Å
Organisms	Homo sapiens
Macromolecule	CYCLOPHILIN A (protein) PEPTIDE FROM THE HIV-1 CAPSID PROTEIN (protein)

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1AWS	Download File View File

SECYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER)

Vajdos, F.F.

(1997) Protein Sci 6: 2297-2307

Released	1998-03-18
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	CYCLOPHILIN A (protein) PEPTIDE FROM THE HIV-1 CAPSID PROTEIN (protein)

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1AWT	Download File View File

SECYPA COMPLEXED WITH HAGPIA

Vajdos, F.F.

(1997) Protein Sci 6: 2297-2307

Released	1998-03-18
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	CYCLOPHILIN A (protein) PEPTIDE FROM THE HIV-1 CAPSID PROTEIN (protein)

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1AWU	Download File View File

CYPA COMPLEXED WITH HVGPIA (PSEUDO-SYMMETRIC MONOMER)

Vajdos, F.F.

(1997) Protein Sci 6: 2297-2307

Released	1998-03-18
Method	X-RAY DIFFRACTION 2.34 Å
Organisms	Homo sapiens
Macromolecule	CYCLOPHILIN A (protein) PEPTIDE FROM THE HIV-1 CAPSID PROTEIN (protein)

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1AWV	Download File View File

CYPA COMPLEXED WITH HVGPIA

Vajdos, F.F.

(1997) Protein Sci 6: 2297-2307

Released	1998-03-18
Method	X-RAY DIFFRACTION 2.34 Å
Organisms	Homo sapiens
Macromolecule	CYCLOPHILIN A (protein) PEPTIDE FROM THE HIV-1 CAPSID PROTEIN (protein)

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1B6C	Download File View File

CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12

Huse, M., Chen, Y.-G., Massague, J., Kuriyan, J.

(1999) Cell 96: 425-436

Released	1999-06-15
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	FK506-BINDING PROTEIN (protein) TGF-B SUPERFAMILY RECEPTOR TYPE I (protein)
Unique Ligands	SO4

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1BCK	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-THR CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-09-16
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens Tolypocladium inflatum
Macromolecule	CYCLOSPORIN C (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (protein)

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1BKF	Download File View File

FK506 BINDING PROTEIN FKBP MUTANT R42K/H87V COMPLEX WITH IMMUNOSUPPRESSANT FK506

Itoh, S., Decenzo, M.T., Livingston, D.J., Pearlman, D.A., Navia, M.A.

(1995) Bioorg Med Chem Lett 5: 1983

Released	1996-08-01
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	FK506 BINDING PROTEIN (protein)
Unique Ligands	FK5

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1BL4	Download File View File

FKBP MUTANT F36V COMPLEXED WITH REMODELED SYNTHETIC LIGAND

Hatada, M.H., Clackson, T., Yang, W., Rozamus, L.W., Amara, J., Rollins, C.T., Stevenson, L.F., Magari, S.R., Wood, S.A., Courage, N.L., Lu, X., Cerasoli Junior, F., Gilman, M., Holt, D.

(1998) Proc Natl Acad Sci U S A 95: 10437-10442

Released	1998-09-02
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (FK506 BINDING PROTEIN) (protein)
Unique Ligands	AP1

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1C5F	Download File View File

CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A

Ellis, P.J., Carlow, C.K.S., Ma, D., Kuhn, P.

(2000) Biochemistry 39: 592

Released	1999-12-03
Method	X-RAY DIFFRACTION 2.47 Å
Organisms	Brugia malayi Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 1 (protein)

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1C9H	Download File View File

CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN

Deivanayagam, C.C.S., Carson, M., Thotakura, A., Narayana, S.V.L., Chodavarapu, C.S.

(2000) Acta Crystallogr D Biol Crystallogr 56: 266-271

Released	2000-08-03
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	FKBP12.6 (protein)
Unique Ligands	RAP

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1CLH	Download File View File

THREE-DIMENSIONAL SOLUTION STRUCTURE OF ESCHERICHIA COLI PERIPLASMIC CYCLOPHILIN

Clubb, R.T., Wagner, G.

(1994) Biochemistry 33: 2761-2772

Released	1994-05-31
Method	SOLUTION NMR
Organisms	Escherichia coli
Macromolecule	CYCLOPHILIN (protein)

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1CWA	Download File View File

X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN A-CYCLOSPORIN A CRYSTAL COMPLEX AT 2.1 ANGSTROMS RESOLUTION

Mikol, V., Kallen, J., Walkinshaw, M.D.

(1993) J Mol Biology 234: 1119

Released	1996-01-29
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (protein)

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1CWB	Download File View File

THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY

Mikol, V., Kallen, J., Walkinshaw, M.D.

(1994) Protein Eng 7: 597

Released	1996-01-29
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (protein)

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1CWC	Download File View File

IMPROVED BINDING AFFINITY FOR CYCLOPHILIN A BY A CYCLOSPORIN DERIVATIVE SINGLY MODIFIED AT ITS EFFECTOR DOMAIN

Mikol, V.

(1994) J Med Chem 37: 3674

Released	1996-01-29
Method	X-RAY DIFFRACTION 1.86 Å
Organisms	Homo sapiens Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (protein)

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1CWF	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-07-15
Method	X-RAY DIFFRACTION 1.86 Å
Organisms	Homo sapiens Tolypocladium inflatum
Macromolecule	CYCLOSPORIN D (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (protein)

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1CWH	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 3-D-SER CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-07-15
Method	X-RAY DIFFRACTION 1.86 Å
Organisms	Homo sapiens Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (protein)

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1CWI	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-08-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens Tolypocladium inflatum
Macromolecule	CYCLOSPORIN D (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (protein)

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1CWJ	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-S-METHYL-SARCOSINE CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-08-26
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens Tolypocladium inflatum
Macromolecule	CYCLOSPORIN D (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (protein)

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1CWK	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-07-15
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens Tolypocladium inflatum
Macromolecule	CYCLOSPORIN D (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (protein)