Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
Nitroglicerina
Glyceryl trinitrate
NG
Glycerol trinitrate
1,2,3-propanetrioltrinitrate
1,2,3-propanetriyl nitrate
Glycerin trinitrate
Glyceroli trinitratis
Glyceroltrinitrat
Glycerol, nitric acid triester
Nitroglycerin
Trinitrine
Trinitroglycerin
Nitromed
Trinitroglycerol
Nitroglycerol
Nitroglycerine
Propane-1,2,3-triyl trinitrate
Brand Names
Mylan-nitro Patch 0.4
Trinipatch 0.4
Nitroject Inj 1mg/ml
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Nitrol
Deluxe Dental Emergency Kit
Nitrolingual Spray 0.4mg/eam
Mylan-nitro Patch 0.6
Nitroglycerin ER
Nitroglycerin Injection USP
Nitro-dur 0.4
Nitroglycerin Transdermal System
Nitroglycerin Inj 5mg/ml
Nitroglycerin Lingual
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Transderm-nitro 0.8
Minitran
Nitroglycerin
Transderm Nitro
Nitro-dur 0.2
Nitro-Time
Transderm-nitro 0.2
Nitrolingual
Nitronal
Nitro-time
Rho-nitro Pumpspray
Mylan-nitro Patch 0.2
Nitro-dur 0.8
Apo-nitroglycerin
Nitroglycerin Transdermal Infusion System
Nitroject
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Transderm-nitro 0.6
Nitroglycerin Slocaps
Tridil Injection 5mg/ml
Nitroglycerin Transdermal Delivery System
Nitro-dur
Nitrolingual Pumpspray
Nitrostat
Rectiv
Trinipatch 0.6
Minitran - Patch Trd 72mg/26.6 Sq Cm
Nitrong SR Srt 2.6mg
Mylan-nitro Patch 0.8
Nitroglycerin SR
Transderm-nitro 0.4
Basic Dental Emergency Kit
Trinipatch 0.2
Gonitro
NitroMist
Mylan-nitro Sublingual Spray
Nitrogard-SR Tab 1mg
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Nitroglycerin In Dextrose
Nitro-bid
Nitro-dur 0.6
Nitroglycerin in Dextrose
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
