TMG

2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE

Created:	2005-02-25
Last modified:	2011-06-04

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2 entries where TMG is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	21
Chiral Atom Count	0
Bond Count	23
Aromatic Bond Count	16

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Chemical Component Summary
Name	2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE
Systematic Name (OpenEye OEToolkits)	2-(1,3-thiazol-4-yl)-1H-benzimidazole
Formula	C₁₀ H₇ N₃ S
Molecular Weight	201.248
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	n2c1c(cccc1)nc2c3ncsc3
SMILES	CACTVS	3.341	[nH]1c2ccccc2nc1c3cscn3
SMILES	OpenEye OEToolkits	1.5.0	c1ccc2c(c1)[nH]c(n2)c3cscn3
Canonical SMILES	CACTVS	3.341	[nH]1c2ccccc2nc1c3cscn3
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc2c(c1)[nH]c(n2)c3cscn3
InChI	InChI	1.03	InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
InChIKey	InChI	1.03	WJCNZQLZVWNLKY-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00730
Name	Thiabendazole
Groups	approved vet_approved
Description	2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)
Synonyms	2-(thiazol-4-yl)benzimidazole 2-(4-thiazolyl)-1H-benzimidazole Tiabendazolum 2-(1,3-thiazole-4-yl)-1H-benzimidazole Tiabendazole Tiabendazol TBDZ Thiabendazole 4-(2-benzimidazolyl)thiazole
Brand Names	Mintezol Chewable Tab 500mg Mintezol
Indication	For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.
Categories	Anthelmintics Anti-Infective Agents Antifungals for Dermatological Use Antifungals for Topical Use Antihelminthic Antinematodal Agents Antiparasitic Agents Antiparasitic Products, Insecticides and Repellents Benzimidazole Derivatives Benzimidazoles Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Drugs that are Mainly Renally Excreted Heterocyclic Compounds, Fused-Ring Imidazole and Triazole Derivatives Sulfur Compounds Thiazoles
ATC-Code	D01AC06 P02CA02
CAS number	148-79-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Fumarate reductase flavoprotein subunit	MQTFQADLAIVGAGGAGLRAAIAAAQANPNAKIALISKVYPMRSHTVAAE...	unknown	inhibitor
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	substrate,inhibitor
Cytochrome P450 1A1	MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIG...	unknown	inducer

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682