TES

TESTOSTERONE

Created:1999-07-08
Last modified:  2011-06-04

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Chemical Details

Formal Charge0
Atom Count49
Chiral Atom Count6
Bond Count52
Aromatic Bond Count0
2D diagram of TES
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Chemical Component Summary

NameTESTOSTERONE
Systematic Name (OpenEye OEToolkits)(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
FormulaC19 H28 O2
Molecular Weight288.424
TypeNON-POLYMER

Chemical Descriptors

TypeProgramVersionDescriptor
SMILESACDLabs10.04O=C4C=C3C(C2CCC1(C(CCC1O)C2CC3)C)(C)CC4
SMILESCACTVS3.341C[C]12CC[CH]3[CH](CCC4=CC(=O)CC[C]34C)[CH]1CC[CH]2O
SMILESOpenEye OEToolkits1.5.0CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C
Canonical SMILESCACTVS3.341 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
Canonical SMILESOpenEye OEToolkits1.5.0 C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@]34C
InChIInChI1.03 InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
InChIKeyInChI1.03 MUMGGOZAMZWBJJ-DYKIIFRCSA-N

Drug Info: DrugBank

DrugBank IDDB00624 
NameTestosterone
Groups
  • approved
  • investigational
DescriptionTestosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual characteristics.[A187114,L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone was isolated from samples and also synthesized in 1935.[A186943]
Synonyms
  • Testostérone
  • Testosterone
  • Virosterone
  • 17beta-hydroxy-4-androsten-3-one
  • Testosteron
Brand Names
  • Fortesta
  • Axiron
  • Natesto nasal gel
  • Testosterone Gel, 1%
  • Intrinsa
IndicationTestosterone is indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995]
Categories
  • 3-Oxoandrosten (4) Derivatives
  • Anabolic Steroids
  • Androgens
  • Androgens and Estrogens
  • Androstanes
ATC-Code
  • G03BA03
  • G03EA02
CAS number58-22-0

Drug Targets

NameTarget SequencePharmacological ActionActions
Androgen receptorMEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPP...unknownagonist
Estrogen receptorMTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPA...unknowninhibitor
Mineralocorticoid receptorMETKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSC...unknownligand
Cytochrome P450 3A4MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...unknownsubstrate,inducer
Cytochrome P450 3A5MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...unknownsubstrate
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL386630
PubChem 6013
ChEMBL CHEMBL386630
ChEBI CHEBI:17347
CCDC/CSD TESTON10, TESTOM01, EFEJAD