RWF

R-WARFARIN

Find entries where: RWF

is present as a standalone ligand in 3 entries

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Chemical Component Summary
Name	R-WARFARIN
Identifiers	4-hydroxy-3-[(1R)-3-oxo-1-phenyl-butyl]chromen-2-one
Formula	C₁₉ H₁₆ O₄
Molecular Weight	308.328
Type	NON-POLYMER
Isomeric SMILES	CC(=O)C[C@H](c1ccccc1)C2=C(c3ccccc3OC2=O)O
InChI	InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/t15-/m1/s1
InChIKey	PJVWKTKQMONHTI-OAHLLOKOSA-N

Chemical Details
Formal Charge	0
Atom Count	39
Chiral Atom Count	1
Bond Count	41
Aromatic Bond Count	17

Drug Info: DrugBank

DrugBank ID	DB08496
Name	(R)-warfarin
Groups	experimental
Description	Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in producing an anticoagulant response.[A1038]
Synonyms	R-warfarin (R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one (+)-warfarin (R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one R,R-Warfarin alcohol (R)-warfarin
Categories	Anticoagulants Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C18 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Vitamin K Antagonists
CAS number	40281-89-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	substrate
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	substrate
Cytochrome P450 2C18	MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDM...	unknown	substrate
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	substrate
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	substrate
Cytochrome P450 1A1	MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIG...	unknown	substrate
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682