RCO

RESORCINOL

Created:1999-07-08
Last modified:  2020-06-05

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Chemical Details

Formal Charge0
Atom Count14
Chiral Atom Count0
Bond Count14
Aromatic Bond Count6
2D diagram of RCO
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Chemical Component Summary

NameRESORCINOL
Synonyms1,3-BENZENEDIOL; 1,3-DIHYDROXYBENZENE
Systematic Name (OpenEye OEToolkits)benzene-1,3-diol
FormulaC6 H6 O2
Molecular Weight110.111
TypeNON-POLYMER

Chemical Descriptors

TypeProgramVersionDescriptor
SMILESACDLabs10.04Oc1cccc(O)c1
SMILESCACTVS3.341Oc1cccc(O)c1
SMILESOpenEye OEToolkits1.5.0c1cc(cc(c1)O)O
Canonical SMILESCACTVS3.341 Oc1cccc(O)c1
Canonical SMILESOpenEye OEToolkits1.5.0 c1cc(cc(c1)O)O
InChIInChI1.03 InChI=1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H
InChIKeyInChI1.03 GHMLBKRAJCXXBS-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank IDDB11085 
NameResorcinol
Groups approved
DescriptionResorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders and infections such as acne, seborrheic dermatitis, eczema, psoriasis, corns, calluses, and warts. It exerts a keratolytic activity. Resorcinol works by helping to remove hard, scaly, or roughened skin. Although it is primarily indicated for use as a topical application, resorcinol also possesses a well-documented anti-thyroidal activity that is generally not relied upon for any kind of formal therapeutic indication.
Synonyms
  • Resorzin
  • m-hydroxyphenol
  • m-Hydroquinone
  • 1,3-Benzenediol
  • 1,3-Dihydroxybenzene
Brand Names
  • Adult Acnomel
  • Tinted Acne Treatment
  • Vagicaine
  • Hemo-pic
  • Mirakel Pain and Itch Relief
IndicationContemporary therapeutic uses for resorcinol primarily revolve around the use of the phenol derivative as an active ingredient in topical antiseptics [L2745, L2744, L40069, F61] or as topical antibacterial skin treatment products for conditions like acne, seborrheic dermatitis, eczema, and others [L2746, L2745, L2744, L40069, F61].
Categories
  • Anti-Acne Preparations
  • Anti-Acne Preparations for Topical Use
  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Benzene Derivatives
ATC-Code
  • D10AX02
  • S01AX06
CAS number108-46-3

Drug Targets

NameTarget SequencePharmacological ActionActions
Carbonic anhydrase 12MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSC...unknowninhibitor
Carbonic anhydrase 2MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVS...unknowninhibitor
Carbonic anhydrase 14MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDI...unknowninhibitor
Prostaglandin G/H synthase 1MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFG...unknowninhibitor
Thyroid peroxidaseMRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLV...unknown
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 5054
ChEMBL CHEMBL24147
ChEBI CHEBI:27810
CCDC/CSD GAJROB, HOLKAW, IGIZEG01, KAJFEJ, IGIZAC, ACOYOG01, EDAZOB, EDAYIU, ABEKUN03, ABEKUN02, ABELAU06, ABEKUN04, HOPKED, IGIZEG, ABEKUN01, DUVHAE01, ACOYOG, DEGQUE, ABELAU03, ABELAU02, ABELAU01, EJIXUQ, DOGCIO, ABELAU04, EBIMIM, ABELAU05, BODSAO, KIHZAD, ANUNED, GAVBAI, KEXHUR, FOSFOK, AXEZIM, ABEKUN, KEXJIH, ABELAU, DUVHAE, JORBEA, COZZUN, ABELIC, ASORIL, ITUJOX, AXOGIE, GIHBUW, CEKBOJ, BULLAX, KIJLAS, IMIWAF, IYAZEQ