Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.
Synonyms
Piperazine citrate
Piperazine phosphate
Diethylenediamine
Piperazidine
Piperazine monohydrochloride
Piperazin
Piperazine hydrochloride
Piperazine hydrate
Piperazina
Piperazine
Piperazine hexahydrate
Piperazine sulfate
Piperazine adipate
Brand Names
Veriga 125
Formule C34
Entacyl Susp 0.6gm/5ml
Vermirex Syr
Entacyl Granules 2.0gm
Entacyl Granules
Entacyl Suspension-600mg/5ml
Versol 100mg
Indication
Used as alternative treatment for ascariasis caused by <i>Ascaris lumbricoides</i> (roundworm) and enterobiasis (oxyuriasis) caused by <i>Enterobius vermicularis</i> (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
Categories
Anthelmintics
Anti-Infective Agents
Antinematodal Agents
Antiparasitic Agents
Antiparasitic Products, Insecticides and Repellents
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
