PX9

Pramocaine

Created:	2015-02-06
Last modified:	2015-07-01

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6 entries where PX9 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	48
Chiral Atom Count	0
Bond Count	49
Aromatic Bond Count	6

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Chemical Component Summary
Name	Pramocaine
Systematic Name (OpenEye OEToolkits)	4-[3-(4-butoxyphenoxy)propyl]morpholine
Formula	C₁₇ H₂₇ N O₃
Molecular Weight	293.401
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	O(c2ccc(OCCCN1CCOCC1)cc2)CCCC
SMILES	CACTVS	3.385	CCCCOc1ccc(OCCCN2CCOCC2)cc1
SMILES	OpenEye OEToolkits	1.9.2	CCCCOc1ccc(cc1)OCCCN2CCOCC2
Canonical SMILES	CACTVS	3.385	CCCCOc1ccc(OCCCN2CCOCC2)cc1
Canonical SMILES	OpenEye OEToolkits	1.9.2	CCCCOc1ccc(cc1)OCCCN2CCOCC2
InChI	InChI	1.03	InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3
InChIKey	InChI	1.03	DQKXQSGTHWVTAD-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB09345
Name	Pramocaine
Groups	approved
Description	Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications in various topical preparations. It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.
Synonyms	Pramoxine hydrochloride Pramocaine Pramocaína Pramoxine
Brand Names	Triple Antibiotic Caldyphen Clear Anodan-plus Ointment Hemorrhoidal Ointment Antibiotic Plus Pain Relief Sunmark Hemorrhoidal Hemorrhoidal Relief Johnson and Johnson First Aid All Purpose 160 CT HEB Calagesic hydrocortisone acetate pramoxine HCl Mineral Oil, Pramoxine Hydrochloride and Zinc Oxide Cortaine -B Aqueous Triple Antibiotic plus pain relief Clear Anti Itch Pentrexcilina Triple Antibiotic Plus Pain Relief L-Topical CALAMINE 8% PRAMOXINE HCL 1% Cocoskin Oto End 10 Triple Antibiotic Plus Equaline Triple Antibiotic Plus Harris Teetter Calagesic Walgreens Kids Multi-Antibiotic with Pain Relief Cream Equate Antibiotic Plus Pain, Itch, Scar Relief Extra Strength Bacitraycin Plus Natureplex Hemorrhoidal QC Medicated anti itch Hemorrhoid Ointment WinCo Maximum Strength Triple Antibiotic Calamine Publix antibiotic plus pain relief Poison Ivy Wash Proctofoam HC Gold Bond Intensive Relief Anti-Itch Band Aid Antiseptic Cleansing Topcare Antibiotic Signature Care Triple Antibiotic Itch Relief Moisturizing Lotion Harris Teeter Triple Antibiotic Plus Pain Relief Soothing Care Itch Relief Spray ATOPALM Hemorrhoidal Pain Relieving Sunmark Caldiphen Skin Relief Medicated Anti-itch Treatment Caladryl Clear Premier Value Calagesic Antibiotic Plus Pain Relief Maximum Strength Aveeno Anti Itch Concentrated LOLA Vaginal Itch Relief Wipes Galentic Triple Antibiotic Plus Pain Relief Vida Mia Calaclear Select Brand Anti-Itch Gold Bond Intensive Healing Anti Itch Skin Protectant Premier Value Calaclear CVS Medicated anti itch CVS Fragrance Free Anti-Itch Leader CVS Calamine Plus Antibiotic and Pain Relief Maximum Strength Equaline Antibiotic Plus Pain Relief Premier Value Max Strength Antibiotic plus pain relief Atopalm First Aid Triple Antibiotic plus Pain Relief Proctofoam GoodSense Antibiotic plus Pain Relief Analpram Advanced Bikini Zone Medicated After Shave Spray Welly Bravery First Aid Kit Novacort ZyPram Itch-X Calamine Clear Itch Relief Moisturizing Cream Aveeno Restorative Skin Therapy Itch Relief Balm Aveeno Calamine and Pramoxine Hydrochloride Anti Itch Care One Maximum Strength First Aid Antibiotic Welly Bravery Triple Antibiotic with Pain Relief Polysporin Itch Relief Publix antibiotic plus Pain Relief Caladryl Hemorrhoidal Oticin HC Ear Drops Triple antibiotic and pain itch scar Tronolane Best Choice Anti-Itch Clear Triple Antibiotic and Pain Relief Maximum Strength Hemorrhoidal Cream Western Family Antibiotic Plus Pain Relief Anusol Plus Ointment Equate First Aid Antibiotic Pain Relieving Anugesic-HC Suppositories Shopko Triple Antibiotic Plus Preferred Plus Hemorrhoid TopCare Calaclear Basic Care First Aid Antibiotic and Burn Relief Glycerin, Phenylephrine Hydrochloride, Pramoxine, White Petrolatum Aveeno Anti-Itch Concentrated First Aid Triple Antibiotic and Pain Relief Maximum Strength Childrens Double Antibiotic with Pain Relief Good Sense Hemorrhoidal Maximum Strength Pain Relief MAXIMUM STRENGTH MEDICATED ANTI-ITCH Rite Aid Rite Aid Pharmacy Antibiotic With Pain Relief Pramoxine hydrochloride HEB Calaclear Signature Care First Aid Antibiotic Quality Choice Triple Antibiotic Plus Pain Reliever Dermarest Eczema Medicated Moist for Sensitive Skin Neosporin Pain Itch Scar meijer Antibiotic Plus Pain Relief Anti-Itch Neosporin Kids Plus Pain Relief Smart Sense antibiotic plus pain relief Clear Itch Relief Pramosone Triple Antibiotic and Pain Relief Neosporin Plus Pain Relief Neo To Go First Aid Antibiotic Pain Relieving Exchange Select First Aid Triple Anitbiotic Pain Relieving Anti-Itch Soothing Wipes 1 Pramoxine Hydrochloride Equaline Triple Antibiotic Rite Aid Soothing Medicated Anit-Itch Bi-Mart Triple Antibiotic plus Pain Relief CeraVe Itch Relief Moisturizing Antibiotic Penimixcina Dr. Sheffield Hemorrhoid Tronothane Pramoxine HCl Crm 1% USP Hemorrhoidal Anesthetic Acella Hydrocortisone Acetate - Pramoxine Singles First Aid Clear Anti-Itch medicated pads Rite Aid Tucks Fast Relief Analpram HC Atopalm First Aid Triple Antibiotic Protection Moisturizing and Pain Relief Triple Antibiotic with Pain Relief Maximum Strength DDM Calagesic Natureplex Antibiotic plus Pain Honey Pot Meijer Triple Antibiotic Plus Epifoam Signature Care Hemorrhoidal Cream (with applicator) Family Care Triple Antibiotic Plus Pain Relief Calamine Plus Anti Itch Soothing 1 Pramoxine Hydrochloride Neosporin Plus Pain Relief Clubtray CVS Health Hemorrhoidal Cream Aveeno Active Naturals Skin Relief Medicated Anti Itch Treatment Western Family Triple Antibiotic plus Pain Relief Quality Choice Maximum Strength Triple Antibiotic Premier Value Antibiotic Plus Pain Relief Rexall Maximum Strength Hemorrhoidal Sally Hansen Zero bump bikini Up and Up First Aid Antibiotic Pain Relieving Walgreen Anti-Itch Sunmark Caldyphen Clear Proctofoam-HC Tripleantibioticointmentandpainrelief Calamine Plus Pramoxine HCL Leader Triple antibiotic and pain relief Equate First Aid Antibiotic Plus Pain Relief TopCare Antibiotic Plus Pain Relief Proctodan-HC Ointment Neosporin Plus Pain Relief First Aid Antibiotic Pain Relieving For Kids Gold Bond Medicated Anti-itch Cream Antibiotic and Pain Relief Hydro Ear Neosporin Plus Pain Relief First Aid Antibiotic/Pain Relieving Equaline Antibiotic Plus Pain Relief for Kids Itch X Up and Up multi action antibiotic CeraVe Itch Relief Moisturizing Cream Clear Anti-itch Lotion CVS Maximum Strength Feminine Anti-Itch Wipes DDM Calaclear Publix Calamine Medicated Publix Clear Anti-Itch CVS Health Maximum Strength Feminine Tripleantibioticapainscaritch Analpram E Cream 2.5% Kit hydrocortisone acetate 2.5% pramoxine hydrochloride 1% Triple Antibiotic Plus Pain Relief Clear Anti-Itch Ivy Wash Avedana Hemorrhoidal Maximum Strength Equaline First Aid Antibiotic First Aid Maximum Strength Bacitraycin Plus Hemorrhoidal Cream with Aloe Smart Sense Triple Antibiotic DerMend Moisturizing Anti-Itch Anuzinc HC Plus Dr Bells Pomade Sandoz Anuzinc Plus proctofoam HC Oticin CAREONE Antibiotic Plus Pain Relief PREPARATION H Maximum Strength Hydrocortisone Acetate Pramoxine Hcl Premier Value Triple Antibiotic Plus Walgreens Maximum Strength Hemorrhoidal CVS Pharmacy Careone Triple Antibiotic Fleet Antibiotic, Pain and Scar Family Wellness Pain Scar Itch CeraVe Developed with Dermatologists Itch Relief Moisturizing SIMPLE PROMISE Simple H Hemorrhoid Relief Cream Rugby Caldyphen Clear Pramosone E Cream 2.5% hydrocortisone acetate 2.5% pramoxine hydrochloride 1% First Aid Antibiotic Plus Pain Relief Maximum Strength Anodan-plus meijer Triple Antibiotic plus Pain Relief Select Brand Hemorrhoid TopCare Triple Antibiotic Plus Pain Relief LEADER Caldyphen Clear Anugesic-HC Ointment Prax Wipe Itch X Gel Equate Antibiotic Plus Pain Relief Hydrocortisone Acetate Pramoxine HCl Family Care Maximum Strength Medicated Anti Itch Triple Antibiotic Plus Pain Relief Maximum Strength Reeses Pinworm Itch Relief NATUREPLEX ANTIBIOTIC plus PAIN RELIEF Triple Antibiotic and Burn Relief Gold Bond Anti-itch Lotion Pramosone Cream Best Choice Medicated Calamine Multi Action Humco Calagesic First Aid Antibiotic plus Burn Relief Pramoxine-HC Sandoz Anuzinc HC Plus Anti-Itch Wipes Cuadriderma Hemorrhoidal Maximum Strength Pain Relief LiveBetter Antibiotic Plus Pain Relief Good Sense Triple Antibiotic Prosoria Anti-Itch Moisturizer Hemorrhoidal Ointment With Anesthetic for Extra Pain Relief First Aid Antibiotic Pro-relief Sheffield Triple Antibiotic Plus Pain Relief CVS Hemorrhoidal Family Wellness Plus Pain Relief Clear Itch Relief Evora Labs Hydrocortisone Acetate 2.5% Pramoxine HCl 1% Curad Maximum Strength Triple Antibiotic Johnson and Johnson First Aid Travel Ready 80 CT GNP Caldyphen Anuzinc Plus Suppositories Healthy Accents Triple Antibiotic Pramox HC Cream Pramoxine Hydrochloride First Aid Triple Antibiotic Pain and Scar Meijer Antibiotic Plus Pain Relief Blistex Ivarest Poison Ivy Itch DG Health Medicated Anti-Itch Analgesic Hydrocortisone Acetate and Pramoxine Hydrochloride Itch Relief Lotion W15883-CS Dermagesic Equaline Hemorrhoidal First On Topical Analgesic Neosporin Plus Pain Relief Neo To Go First Aid Antiseptic Pain Relieving For Kids Aveeno Calm Plus Restore Itch Relief Balm Bacitraycin Plus MEDICATED ANTI-ITCH Well at Walgreens Good Sense Triple Antibiotic and Pain Relief Shopko Triple Antibiotic plus Pain Relief Freds Medicated anti itch CVS Anti-Itch First Aid Antibiotic and Pain Relief Neosporin Plus Pain Relief Neo To Go First Aid Antiseptic Pain Relieving TopCare Calagesic Luvena Feminine Wipes Analpram E Basic Care First Aid Antibiotic VAGISIL Anti-Itch Medicated Wipes Maximum Strength CVS Pharmacy Maximum Strength Feminine Wipes Scalpicin Medicated Wipes Itch Relief Balm Hydrocortisone Acetate Pramoxine Hydrochloride Topcare Hemorrhoidal Prax Signature Care Hemorrhoidal CVS Medicated Anti-Itch Rite Aid Cala Itch Relief Vagisil Medicated Wipes Neosporin Plus Pain Relief Itch Relief Medicated Pads CVS Oti Rx Leader Triple Antibiotic Plus Sarna Sensitive Anti-itch Lotion Procort Pramosone E Eczemin Hemorrhoidal Pain Relief Private Label Poison Ivy Wash Leader Triple Antibiotic and Pain Relief Proctofoam NS Good Neighbor Pharmacy Antibiotic and Pain Relief DCH Calaspray Itch Relief Smart Sense triple antibitotic plus pain relief Family Wellness Triple Antibiotic Plus Pain Relief Antibiotic plus Pain Relief Triple Antibiotic plus Pain Relief Maximum Strength Fissurene HC Pram Select Brand Calaclear CareALL Triple Antibiotic plus Pain Relief DG Health Antibiotic Anesthetic Hemorrhoidal With Aloe Triple antibiotic and pain relief Sunmark Triple Antibiotic Plus Pain Relief Sunmark Antibiotic Plus Pain Relief Cortane-B PrameGel Gold Bond Anti Itch Calaclear First Degree Maximum Strength Burn Double Antibiotic Plus Pain Relief Maximum Strength Sarna P NEOSPORIN Plus BURN RELIEF AVON HeXashield Triple Antibiotic with Pain Relief Bactine Pain Relieving Cleansing Spray Pramoxine Itch relief Bacitraycin MAX Pain Relief Curasore Family Wellness Antiseptic and Pain Relief Ear Itch MD Band Aid Antiseptic Cleansing To Go CVS Health Triple Antibiotic with Pain Relief First Aid Antiseptic Pain Relieving Safeway Antibiotic Plus Pain Relief Anusol Plus Suppositories Pomada De La Campana Triple Antibiotic Pain Relief Equate Hemorrhoidal Itch Relief Clear Skin Protectant CVS Triple Antibiotic Plus Maximum Strength Shopko Antibiotic Plus Pain Relief No More Bumps Drs. Pharmacy Triple Antibiotic Plus Neosporin Plus Pain Relief Neo to Go Triple Antibiotic with Pain Relief Pramox HC Lotion Basic Care First Aid Antibiotic Plus Pain Relief Quality Choice Anti-Itch Clear Bite and Itch HEB Maximum Strength Pain Relief Hemorrhoidal H E Buddy Antibiotic Maximum Strength Plus Pain Relief First Aid Antibiotic Bacitraycin Plus Maximum Strength Sarna Blistex Cold and Allergy Lip Soother CVS Itch Relief Tucks Hemorrhoidal Calamine Plus Pramoxine HCl Bikini Zone MEDICATED After Shave Fresh Scent Johnson and Johnson All Purpose First Aid Kit Pain Relief TheraCare Triple Antibiotic Pain Relief Up and Up Antibiotic Plus Pain Relief Walgreens Maximum Strength Triple Antibiotic With Pain Relief Oncoderm ItchRx First Aid Sensitive Anti-Itch Dual Action Cream Family Wellness Polysporin Lip Treatment Dermoplast Poison Ivy Treatment Leader Calamine Plus Rexall Hemorrhoidal Up and Up Hemorrhoidal Best Choice Medicated anti itch Anti Itch Maximum Relief LEADER Caldyphen Quality Choice Anti-itch Medicated Natureplex Antibiotic Plus Pain, Itch, Scar Relief Nikzon Hemorrhoidal Polysporin Poly To Go Walgreens Multi-Antibiotic with Pain Relief Cream Humco Calaclear Preparation H Totables Pain Relief Live Better Triple Antibiotic plus Pain Relief Good Neighbor Pharmacy Triple Antibiotic Plus Pain Relief Bikini Zone Medicated After-shave Roll-ON Relief Topcare Triple Antibiotic Antibiotic and pain relief maximum strength Itch-X Gel Multi Antibiotic with Pain Relief Maximum Strength Shoprite Triple Antibiotic Smart Sense Antibiotic Maximum Strength Aveeno Anti-itch Lotion Dg Health Triple Antibiotic OLP Triple Antibiotic Plus Pramcort Leader Poison Ivy Wash Proctodan-HC Suppositories
Indication	It is indicated for temporary relief of pain and pruritus from minor lip and skin irritations as well as for temporary relief from pain, burning, itching and discomfort associated with hemorrhoids and other anorectal/anogenital disorders.
Categories	Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Anesthetics Anesthetics for Topical Use Anesthetics, Local Antipruritics and Local Anesthetics Antipruritics, Incl. Antihistamines, Anesthetics, Etc. Central Nervous System Agents Central Nervous System Depressants Dermatologicals Oxazines Peripheral Nervous System Agents Sensory System Agents Vasoprotectives
ATC-Code	D04AB07 C05AD07
CAS number	140-65-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Voltage-gated sodium channel alpha subunit	MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPK...	unknown	blocker

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682