INS

1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE

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is present as a standalone ligand in 36 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 2 entries

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Chemical Component Summary
Name	1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE
Synonyms	MYO-INOSITOL
Identifiers	cyclohexane-1,2,3,4,5,6-hexol
Formula	C₆ H₁₂ O₆
Molecular Weight	180.156
Type	NON-POLYMER
Isomeric SMILES	C1(C(C(C(C(C1O)O)O)O)O)O
InChI	InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6-
InChIKey	CDAISMWEOUEBRE-GPIVLXJGSA-N

Chemical Details
Formal Charge	0
Atom Count	24
Chiral Atom Count	0
Bond Count	24
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB13178
Name	Inositol
Groups	approved investigational withdrawn
Description	Inositol is a collection of nine different stereoisomers but the name is usually used to describe only the most common type of inositol, myo-inositol. Myo-inositol is the cis-1,2,3,5-trans-4,6-cyclohexanehexol and it is prepared from an aqueous extract of corn kernels by precipitation and hydrolysis of crude phytate. These molecules have structural similarities to glucose and are involved in cellular signaling. It is considered a pseudovitamin as it is a molecule that does not qualify to be an essential vitamin because even though its presence is vital in the body, a deficiency in this molecule does not translate into disease conditions.[L2560] Inositol can be found as an ingredient of OTC products by Health Canada but all current product whose main ingredient is inositol are discontinued.[L1113] By the FDA, inositol is considered in the list of specific substances affirmed as generally recognized as safe (GRAS).[L2561]
Synonyms	Meat sugar myo-inositol meso-Inositol Inositol L-myo-Inositol cis-1,2,3,5-trans-4,6-cyclohexanehexol 1,2,3,5/4,6-cyclohexanehexol
Brand Names	Formula F L W Stress B With 1000 Mg Vitamin C Vitalife - Capsule Ultr F/b E.S. Mega Lipotropic Fmla W B6bet Mini-B Tab Multipack II Stress Formula Multi-B Comp + 500mg Vit C Cap Twin Opti Pwr Super-pote Vitamin Supplement Olympian Multi Vit Plus Minerals Tab Stress Formula B-comp + 500mg Vit C Tab Harvest Of Values All B Complex Tab Vita Vim With Beta Carotene-caplet Complete One A Day Tab Vitamin B Complex 50 Timed Release B-complex 100 Ultra Hr Stress B&c Tab Mega Plex IV - Pck B Complex 25mg Vitamin Supplement Stress Ctr Srt Essential B Tablets Low Potency B Complex Tab Dp 2000 Multivitamin & Multimineral Right Choice P.M. Multi Formula - Caplet Choline and Inositol 250mg/250mg Children's Chewable Multivitamins and Minerals B Compound 50mg Tab Swiss One Timed Release Tab Inositol Caps 500mg Prenatvite Stress Forte Plus Lipotropic Factors Super Stress Capsules Hi Potency B52 B Complex Tab Lipo Factors Plus B6 One A Day Multiple Vit W Minerals Lipotrope Tab Lipotropics 600 Tab Multi-phyto Capsules Inositol Tab 250mg Magnum-75 Vitamin and Mineral Supplement Vasula Tab Hi Potency B Complex W Chelated Minerals Multivitamins and Minerals With Betacarotene Tablets Multivitamine Prenatvite Plus Swiss One Multi Vit & Chel Min Tab Women's Formula New Chapter's D'adamo 4 Your Type Multiple for Type O Nrg Plus Liq Revitex Ampoules Et Comprimes B-complex Lipotropic Adjunct Mega Vitaminerals Swiss One Multivitamin and Mineral Caplet Men's Biomultiple Vitamin and Mineral Supplement Revitalize Multi-vitamin and Mineral Complex Super Vita Vim Multivitamins and Minerals Vita-B Maintain Multiple Vitamin & Minerals Vita B Complex Tab Insur-all Vitamin Supplement Calcium Magnesium Plus Vitamin D Liquid Lipovite Palm Spring's PM Form Tab Vitamin B + C Cap Mega Plex III - Pck Lipo-B-C Tab Liqui Vita Vita Balance 2000 Doctor's Choice Brand for Men Amino-cerv Onccor Only One - Tablet Chromium and Vanadium Mineral Supplement Innersource Tab Mega Balance Balanced B 125 Srt Lipotrope-plus B6 Tab Rocky Mountain Multiple Vit and Min Mega Tab B Complex 50 Vitamin Cap Inositol 500mg Vitaplex Formula C.I. Tab Classic Swiss One 10 Multivitamin and Mineral Tab Formula Hh Liquid B Complex 50 Lipotropic Ctr Choline Inositol Methionine Complete Multivitamins and Minerals Tablets Timed Release Multi Spectrum - Tablet Stress Vitamin B With C Complex Tablets Vita Plex Tab Multi B Inositol Tab 405mg Maximum Once A Day Mega Lipotropic Cap Formula 9 Tab Super Multi B50 Complex Bev B-150 Multitabs Timed Release B-complex 50 Vitamin B Complex Suppl Twin G.F. Powder Body Tropics Plus Tab Twin G.F. Powder Vanilla Flavor Natural Source Spectrum With Beta Carotene Extra Once A Day B-50 Complex Multivitamins and Minerals for Young Men Nitro Vites - Tab Children's Chewable Vit and Min Tab B-complex Tab Red American Eagle Vitamin Supplement Drink Stressmates Vita-worth B-complex Tablets 24 Multivitamins + Minerals Choline & Inositol Caps Vege 1 Daily Tab Mega 13 Multivitamin Formula Inositol Ctr Srt 400mg Biosculpt Multicaps Mega Capsules Neonatal Plus Vitamin Complete One-A-day - Tab Multiple Vitamins and Minerals Capsules Stress Formula Vit B With C Complex Inositolex 400mgms Cyruta Tab Orti B Super Vita-vim With Beta-carotene - Tab Complete Mega B C.A.G. Tab Multra With Iron Vitamin B Complex 100 Tab Liqui B Complex Plus Multi Plex II - Tab Hyporyl - Tab Multivitamins and Minerals for Young Women B-plex B-complex 100 Neomultivite Deriton American Plus Energy & Vitamin Drink Derma-force Lipall Plus Tab B-plus - Tab Formula Pro-B Fusion PM Formula Tab Timed Release Vita-vim Srt Vit-HA Multi Vitamin and Zinc Supplement Vita-vim - Tab Hi Potency Stress B Tension With C L Fac Tab Multi Plex I - Tab Wellness Formula Protect Plus SO 60 Multi-force for Women Tab Super Daily No 2 Multi-force for Adults Tab Men's 50+ Vitamin B Tablets Forty Plus Vitamin Supplement Body Rox Ultimate Tab One A Day Tab Mic B12 B 50 Capsules Vitamin & Mineral Formula 1 Dietary Supplement Vitamin B Compound W Vit C 250mg Tab Alertonic Neonatal Vitamin Liqui B Complex Phytovim Cap Stress B Capsules With Vitamin C C. Vit-min Formula Hoa 1 B-complex With Vitamin C, Biotin, Folic Acid Swiss One Bev 29 Tab Stress B & C Caplet B-complex 50 Multivitamin & Minerals (iron Free) For-2 Formula Cm Vita-vim With Beta-carotene - Tab Maxum Multi-vite 50 Plus B-100 Vitamin Supplement Super Stress Mega B Plus 1000mg Vit C Tab Women's Biomultiple Vitamin and Mineral Supplement Advanced 2000 Capsules Grand Master Formula Tab Time Release B 100 Compound - Tablet Inositol 250mg - Tab Inositol-S Tab 400mg Vita Vim Multivitamins and Minerals Tab Daily Energy Brand Vitamin & Mineral Drink Mix Men's Multi Master Formula Vitachrom Gc Gnc Choline/inositol 250mg Tablets Multi Flow Tablets Alkadrenergy Tablets Multi Tabs My Favorite Niacin and Inositol Tab Formula Gly Multi II IV Vi Tab Super B Compound W 500mg Vit C American Eagle Energizer Plus Vitamin Supplement Drink Master Key Multi Vitamin Multi Mineral Formula 2 Prenatal Formula Tab Complexe B Compose 75 Multra Plex Phytopure Vege Swiss One Multivitamin W Chel Mins Tab Vitamin B Compound W C Tab 500mg B-100 Caps L.C. Supplement Maxine Vitamin and Mineral Supplement Vitamin B Complex W C Tab Multivitamins and Minerals for Men Revit Multi-vitamins and Minerals B-complex-50 Tab Formula Lf Hi Potency Multi Tab B Complex 50+ Caplet Multi Vitamin-mineral Formula Timed Release B Complex 100 Srt Usana Megavitamin Tablets - Tab B-50 Hi Potency B Vitamins Tab Prenatal Vi-min Spectrum 2 Cap Bev-lipo-1000 Card-floe II Tab Niacin 500 Mg and Inositol Lip - Fac Formula Stom #2 Vit B Complex Ctr Multivitamins and Minerals for Women H.W. Children's Chewable Multi Vit & Mineral Mega-vim 75 With Beta-carotene - Tablets Inositol Nicotinate Plus CR
Indication	Inositol may be used in food without any limitation. As a drug, inositol is used as a nutrient supplement in special dietary foods and infant formula.[L2561] As it presents a relevant role in ensuring oocyte fertility, inositol has been studied for its use in the management of polycystic ovaries.[A32751] Inositol is also being researched for the treatment of diabetes,[A32766] prevention of metabolic syndrome,[A32768] aid agent for weight loss,[A32769] treatment of depression, psychiatric disorder and anxiety disorder[A32770] and for prevention of cancer.[A32771]
Categories	Alcohols Alimentary Tract and Metabolism Carbohydrates Drugs that are Mainly Renally Excreted Micronutrients Other Nutritional Agents Sugar Alcohols Vitamin B Complex Vitamins
ATC-Code	A11HA07
CAS number	87-89-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Sodium/myo-inositol cotransporter	MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVT...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
CCDC/CSD	MYINOL01, EPINSR, FOPKOK, ZIVVOR, EPINOS, MYINOL02, MYTOLD01, EFURIH04, ZIVVIL, YEPNOW, IFAKAC, UDINUR, MYINCA10, YEPNOW01, EFURIH03, QIKZUH01, MUINOS, EFURIH01, EFURIH, EFURIH02, MYINOL, QIKZAN02, INSMGC, QIKZUH, QIKZAN01, QIKZAN
COD	2212154, 1543051, 1543052, 1543053, 1543054, 1543055, 1543056, 2209541, 2209684

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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INS

1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References