HSM

HISTAMINE

Created:	1999-07-08
Last modified:	2011-06-04

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42 entries where HSM is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	0
Bond Count	17
Aromatic Bond Count	5

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Chemical Component Summary
Name	HISTAMINE
Systematic Name (OpenEye OEToolkits)	2-(1H-imidazol-4-yl)ethanamine
Formula	C₅ H₉ N₃
Molecular Weight	111.145
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	n1c(cnc1)CCN
SMILES	CACTVS	3.341	NCCc1c[nH]cn1
SMILES	OpenEye OEToolkits	1.5.0	c1c(nc[nH]1)CCN
Canonical SMILES	CACTVS	3.341	NCCc1c[nH]cn1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1c(nc[nH]1)CCN
InChI	InChI	1.03	InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKey	InChI	1.03	NTYJJOPFIAHURM-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB05381
Name	Histamine
Groups	investigational approved
Description	A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Synonyms	1H-Imidazole-4-ethanamine Histamine dihydrochloride Histamine Histamine phosphate 2-(4-imidazolyl)ethylamine beta-aminoethylimidazole 5-imidazoleethylamine beta-aminoethylglyoxaline 4-imidazoleethylamine
Brand Names	Positive Skin Test Control-histamine MUSCLESHOK Sport Bakers Best Arthritis Pain Relief with Hemp Seed Australian Dream Back Pain Midalgan Positive Skin Test Control - Histamine Arthritis Pain Relief REVIVE SCIENCE Natural Hemp Pain Relief Rub ActivOn Ultra Strength Arthritis Royal Labs Hemp Recover BAKERS BEST Arthritis Pain Relief Cream with Hemp and Lavender HAVASU HEMP Soothing Pain Relief Rub Arthritis Relief Histamine DHCl 0.10 Percent and Menthol 2 Percent Arthrocare Lotion Glucosamine Cream EXTRA STRENGTH AMINO ACTIVE Topical Analgesic Cream Md Science Cannabigerol Ponos Natural Pain Relief Raging Kakapo Pain Relieve Alo Therapeutic Massage Pain Relieving Dr. Freds MIRACLE RUB MUSCLESHOK Back Pain ROPANA Pain Relief Cream DR. MIKES Ponos Pain Relief Cream Roll-On Bakers Best Arthritis Pain Relief Camphomex Histamine Positive Skin Test Control CVS Arthritis Pain Relief PainMD Max TerraFreeze Pain Relief Rematex Pain Relieving Arthritis Arthritis Pain Relief Cream Histatrol Abee Med Mancore Muscle Mend Roll-ON Pain Reliever Ceplene Histamine DHCl 0.10 Percent Australian Dream Carpal Tunnel Pain Histamine Phosphate Injection USP Liq Sc Alo Therapeutic Massage Australian Dream Pain Relieving Arthritis MINTED LEAF Odorless Histamine DHCl Pain Relief and Hemp Extract Md Science Cannabidiol Minted Leaf Odorless Pain Relief Australian Dream Hand and Wrist Pain Hand and Wrist Pain Cream Histamine Phosphate Injection USP, 1mg/ml Walgreens Arthritis Pain Relief Cream Simanix
Indication	Histamine phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function.
Categories	Adjuvants, Immunologic Amines Antineoplastic and Immunomodulating Agents Autacoids Biogenic Amines Biogenic Monoamines Biological Factors Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 Enzyme Inhibitors Diagnostic Agents Ethylamines Gastric Function Histamine Agents Histamine Agonists Imidazoles Inflammation Mediators Neurotransmitter Agents OCT1 substrates OCT2 Inhibitors OCT2 Substrates Other Diagnostics Tests for Gastric Secretion
ATC-Code	L03AX14 V04CG03
CAS number	51-45-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Histamine H1 receptor	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLY...	unknown	agonist
Histamine H2 receptor	MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLR...	unknown	agonist
Histamine H3 receptor	MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVL...	unknown	agonist
Histamine H4 receptor	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRS...	unknown	agonist
Synaptic vesicular amine transporter	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYS...	unknown
Histamine N-methyltransferase	MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDT...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	substrate,inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682